基于女性性反应增敏的阴蒂暴露术及其对性生活的影响

目的 探讨基于女性性反应增敏的阴蒂暴露术对女性性生活的影响。方法 选取我院2021年1月-6月收治的35例求美者作为研究对象,由同一手术项目组操作;通过阴蒂暴露术将阴蒂暴露1/3;观察手术前及术后6个月求美者阴蒂勃起时间及女性性功能指数量表（FSFI）、女性性苦恼量表（FSDS-R）评分。结果 85.71%求美者阴蒂高潮提前,8.57%表示阴蒂高潮无明显变化,5.71%表示阴蒂敏感度较前下降;术后6个月FSFI评分为（25.93±2.72）分,高于术前的（24.31±3.43）分（P＜0.05）;术后6个月FSDS-R评分为（22.89±6.45）分,低于术前的（25.31±7.07）分（P ＜0.05）。结论 基于性反应增敏的阴蒂暴露术能提升求美者阴蒂性敏感度,有效提高女性性生活满意度,值得在临床应用。     

Nine-year exposure to residential greenness and the risk of metabolic syndrome among Luxembourgish adults: A longitudinal analysis of the ORISCAV-Lux cohort study

Growing evidence shows a beneficial effect of exposure to greenspace on cardiometabolic health, although limited by the cross-sectional design of most studies. This study examined the long-term associations of residential greenness exposure with metabolic syndrome (MetS) and MetS components within the ORISCAV-LUX study (Wave 1: 2007–2009, Wave 2: 2016–2017, n = 395 adults). Objective exposure to residential greenness was measured in both waves by the Soil-Adjusted Vegetation Index (SAVI) and by Tree Cover Density (TCD). Linear mixed models were fitted to estimate the effect of baseline levels and change in residential greenness on MetS (continuous score: siMS score) and its components (waist circumference, triglycerides, HDL-cholesterol, fasting plasma glucose and systolic blood pressure), respectively. This study provides evidence that an increase in SAVI, but not TCD, may play a role in preventing MetS, as well as improving HDL-cholesterol and fasting plasma glucose levels. Greater baseline SAVI was also associated with lower fasting plasma glucose levels in women and participants living in municipalities with intermediate housing price, and greater baseline TCD was associated with larger waist circumference. Overall, findings suggest a mixed impact of increased greenness on cardiometabolic outcomes. Further longitudinal research is needed to better understand the potential effects of different types of greenness exposure on cardiometabolic outcomes.     

染铅对大鼠脾脏NOS、NO、SOD、MDA的影响

目的 探讨染铅对大鼠脾脏一氧化氮合酶（NOS）活力、一氧化氮（NO）含量的影响及其与血铅相互关系。方法 Wistar大鼠经饮水（加0，18．4，184．0mg/L醋酸铅，分别供对照组、低剂量组、高剂量组自由饮用）染毒，测定脾脏NOS活力、NO含量、SOD活力、MDA含量。结果 NOS活力高剂量染铅组7d时显著低于对照组和低剂量组（P＜0．05），90d高于对照组和低剂量组（P＜0．05），低剂量组90d高于对照组（P＜0．05）；NO含量高剂量组和低剂量组60d、90d时均显著低于对照组（P＜0．05）；SOD活力高剂量组14d、30d、60d、90d时均低于对照组（P＜0．05），低剂量组30d、90d时显著低于对照组（P＜0．05）；MDA含量高剂量组14d、60d、90d时均显著高于对照组，60d时显著低于低剂量组，90d时显著高于低剂量组（P＜0．05），低剂量组在各时点与对照组比较，差异无显著性（P＞0．05）。血铅与脾脏NO含量呈倒S型剂量－效应曲线；血铅与脾脏SOD活力呈倒抛物线型剂量－效应曲线；血铅与脾脏MDA含量呈正抛物线型剂量－效应曲线。结论 铅可引起大鼠脾脏NOS活力、NO含量、SOD活力、MDA含量改变，表明铅可引起体内氧应激反应导致脂质过氧化损伤。