Construction Strategy and Progress of Whole Intervertebral Disc Tissue Engineering

Degenerative disc disease (DDD) is the major cause of low back pain, which usually leads to work absenteeism, medical visits and hospitalization. Because the current conservative procedures and surgical approaches to treatment of DDD only aim to relieve the symptoms of disease but not to regenerate the diseased disc, their long‐term efficiency is limited. With the rapid developments in medical science, tissue engineering techniques have progressed markedly in recent years, providing a novel regenerative strategy for managing intervertebral disc disease. However, there are as yet no ideal methods for constructing tissue‐engineered intervertebral discs. This paper reviews published reports pertaining to intervertebral disc tissue engineering and summarizes data concerning the seed cells and scaffold materials for tissue‐engineered intervertebral discs, construction of tissue‐engineered whole intervertebral discs, relevant animal experiments and effects of mechanics on the construction of tissue‐engineered intervertebral disc and outlines the existing problems and future directions. Although the perfect regenerative strategy for treating DDD has not yet been developed, great progress has been achieved in the construction of tissue‐engineered intervertebral discs. It is believed that ongoing research on intervertebral disc tissue engineering will result in revolutionary progress in the treatment of DDD.     

中医药防治放射性肠炎研究进展

本文综述了近3年来关于中医对放射性肠炎的认识、中医药防治放射性肠炎的作用机制以及临床疗效的研究。目前,关于中医对放射性肠炎的认识明确统一;中医药防治放射性肠炎的作用机制明确,但缺乏对有效物质的深入研究;中医药防治放射性肠炎临床疗效显著优于西药治疗,是中医的优势病种,也在传统中药的基础衍生出了一些创新的疗法,但是中医非药物治疗、中西医结合、心理干预联合中医药等防治手段仍然研究较少,中医药用于预防放射性肠炎发生的研究也较少。     

腰背痛治疗进展

近年来随着对腰背痛研究的不断深入,认识的逐步提高,产生了各种各样的治疗方法.本文重点介绍腰背痛的口服药物治疗、注射治疗、麦肯基疗法、持续低剂量热裹法、手术治疗、动力固定系统及心理治疗.     

心肺复苏中自主循环恢复预测及识别方法研究进展

心肺复苏(cardiopulmonary resuscitation,CPR)是心搏骤停时最常用的抢救方法.2010年CPR指南强调高质量胸外按压,建议除颤后继续按压2 min后再判断循环以减少按压中断时间.然而,临床中自主循环恢复(return of spontaneous circulation,ROSC)多发生在按压过程中,此时持续按压不利于自主循环稳定.因此在CPR中识别ROSC十分重要.目前临床上可用于CPR中ROSC的预测和识别方法包括:触及脉搏搏动、波幅谱面积、呼气末二氧化碳分压、冠脉灌注压、中心静脉氧饱和度、胸外按压分数、局部脑氧饱和度、光学容积描记图、结膜氧张力、经胸阻抗容积描记术及超声心动图.本文对以上CPR过程中ROSC预测及识别方法做一综述.     

Transvaginal ultrasonographic cervical measurement in predicting failed labor induction and cesarean delivery for failure to progress in nulliparous women

The aim of this study was to evaluate the value of transvaginal sonographic cervical measurement in predicting failed labor induction and cesarean delivery for failure to progress in nulliparous women. One hundred and sixty-one women scheduled for labor induction underwent transvaginal ultrasonography and digital cervical examinations. Logistic regression demonstrated that cervical length and gestational age at induction, but not the Bishop score, significantly and independently predicted failed labor induction. According to the receiver operating characteristic curves analysis, the best cut-off value of cervical length for predicting failed labor induction was 28 mm, with a sensitivity of 62% and a specificity of 60%. In terms of the likelihood of a cesarean delivery for failure to progress as the outcome variable, logistic regression indicated that maternal height and birth weight, but not cervical length or Bishop score, were significantly and independently associated with an increased risk of cesarean delivery for failure to progress. Transvaginal sonographic measurements of cervical length thus independently predicted failed labor induction in nulliparous women. However, the relatively poor predictive performance of this test undermines its clinical usefulness as a predictor of failed labor induction. Moreover, cervical length appears to have a poor predictive value for the likelihood of a cesarean delivery for failure to progress.     

Incursion dans l’hypertemps

The pandemic has transformed our relationship to time, as it has disrupted our work habits. To understand how these changes affect our world view, it is useful to examine the fundamental patterns that govern our relationship to time, which can be called Destiny, Progress, Hypertemps and Deadlines. What are the links between them? And above all, like leaving a conflicting vision of opposition to build a more peaceful relationship to time. À time when “having time” could retain meaning?     

高表达P4HA3与结直肠癌的进展及不良预后相关

目的 探究基因P4HA3在结直肠癌(colorectal cancer,CRC)的表达及与不良预后的关系。方法 从TCGA数据库获取CRC基因表达数据及临床特征,R软件对P4HA3表达及配对数据可视化分析。卡方检验P4HA3表达与CRC患者临床特征关系。R软件survival包对P4HA3进行生存分析。利用基因表达谱交互分析(GEPIA)数据库验证The Cancer Genome Atlas(TCGA)数据库CRC的P4HA3表达。通过GSEA软件对P4HA3进行KEGG通路富集分析?采用免疫组化染色检测30例CRC患者手术切除样本和30例癌旁组织样本中的P4HA3蛋白表达。结果 与对照组相比,P4HA3在CRC中高表达(P <0.01)。卡方检验显示P4HA3表达与CRC患者Stage、T和N分期密切相关(P <0.05)。生存分析显示与低表达P4HA3患者相比,P4HA3高表达CRC患者的生存时间明显缩短(P < 0.05)。通过GEPIA分析验证了基因P4HA3与CRC不良预后相关(P < 0.05)。进一步GSEA通路富集分析结果显示基因P4HA3富集到的信号通路与多种恶性肿瘤的发生发展有关(FDR < 0.05)。最后,免疫组化检测显示P4HA3蛋白在CRC中高表达,表明P4HA3在CRC发生发展中发挥作用。结论 高表达的基因P4HA3与CRC的进展及不良预后相关,其作用机制可能通过调控多种信号通路来实现。     

中药防治肠源性真菌感染的研究进展

肠源性真菌感染是一种机会性感染，是目前临床上重要的并发症之一。传统的中草药不仅具有抑制和杀灭真菌的作用，还对保护肠道和提高机体的免疫力具有很好的作用，在肠源性真菌感染的治疗方面有广阔的应用前景。     

结直肠癌肝转移手术治疗新进展

近年来,随着对结直肠癌肝转移的发生机制不断深入的研究及新技术的不断出现,结直肠癌肝转移的治疗有了很大的进步。现在以手术为中心的综合治疗及个体化治疗模式已广泛被临床医师接受,但按照传统的手术适应证,仅10%~25%的患者在确诊时适合手术治疗。如何放宽手术指征,以期使不适合手术治疗的患者通过放化疗等辅助治疗使肿块缩小而获得手术治疗,改善结直肠癌肝转移患者的预后,使更多的患者受益,成为近年来研究的热点。     

哮喘治疗新药的研究进展

以吸入激素(inhaled corticosteroid,ICS)为主联合长效β2激动剂等治疗可以使多数哮喘患者得到良好的临床控制。但目前的治疗方法仍不是最理想的疗法。新的治疗药物仍在不断地研发之中,包括新型的ICS、超长效的β2激动剂以及针对哮喘炎症细胞因子的"靶向"治疗药物等。今后这些药物的上市有可能进一步的改善哮喘的治疗。