首页 | 官方网站   微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   22931篇
  免费   1841篇
  国内免费   749篇
医药卫生   25521篇
  2024年   52篇
  2023年   354篇
  2022年   510篇
  2021年   840篇
  2020年   757篇
  2019年   864篇
  2018年   829篇
  2017年   931篇
  2016年   836篇
  2015年   840篇
  2014年   1614篇
  2013年   2495篇
  2012年   1527篇
  2011年   1539篇
  2010年   1211篇
  2009年   1015篇
  2008年   954篇
  2007年   1002篇
  2006年   830篇
  2005年   752篇
  2004年   635篇
  2003年   599篇
  2002年   427篇
  2001年   414篇
  2000年   313篇
  1999年   274篇
  1998年   246篇
  1997年   244篇
  1996年   242篇
  1995年   208篇
  1994年   165篇
  1993年   203篇
  1992年   197篇
  1991年   144篇
  1990年   141篇
  1989年   119篇
  1988年   121篇
  1987年   77篇
  1986年   88篇
  1985年   128篇
  1984年   116篇
  1983年   84篇
  1982年   94篇
  1981年   63篇
  1980年   71篇
  1979年   55篇
  1978年   66篇
  1977年   56篇
  1976年   47篇
  1975年   43篇
排序方式: 共有10000条查询结果,搜索用时 281 毫秒
81.
The antibacterial activity of the volatile oil of Nigella sativa seeds was studied against 37 isolates of Shigella dysenteriae 1, Shigella flexneri, Shigella sonnei and Shigella boydii and 10 strains of Vibrio cholerae and Escherichia coli. Most of the strains were clinically resistant to ampicillin, co-trimoxazole and tetracycline. All the strains tested showed promising sensitivity to the volatile oil. The minimum inhibitory concentration (MIC) of the volatile oil for Shigella, Vibrio and Escherichia strains tested was between 50–400 μg/mL.  相似文献   
82.
Summary The influence of antiepileptics on the evolution of rat amygdaloid kindling was studied.Under placebo conditions clonic convulsions and a spike-wave EEG pattern developed. Diazepam, clonazepam, clobazam and phenobarbital were most effective in suppressing the evolution of kindling; the effects of valproate sodium, ethosuximide and acetazolamide were somewhat less pronounced in this respect. Carbamazepine, oxcarbazepine and phenytoin, on the other hand, enhanced kindling development, i.e. the increase in duration of after-discharge was faster than in the placebo group. The results indicate that under the above experimental conditions drugs with no anti-absence component can be distinguished from those with an anti-absence component. The mechanism of action underlying the observed effects is not yet known; the hypothesis that under special conditions protective inhibitory neuronal activity can develop to absence type seizures is proposed.  相似文献   
83.
An assumption of previous models of hepatic elimination is that there is negligible axial diffusion in the liver. We show, by construction of a stochastic model and analysis of published data, that compounds which are readily diffusible and partitioned into hepatocytes may undergo axial tissue diffusion. The compounds most likely to be affected by axial tissue diffusion are the lipophilic drugs for which the cell membranes provide little resistance and which are highly extracted, thereby creating steep concentration gradients along the sinusoid at steady state. This phenomenon greatly modifies the availability of the compound under conditions of altered hepatic blood flow and protein binding. For moderately diffusible compounds, these relationships are similar to those predicted by the simplistic venous-equilibrium model. Hence, the paradoxical ability of the venous-equilibrium model to describe the steady-state kinetics of lipophilic drugs such as lidocaine, meperidine, and propranolol may be finally resolved. The effects of axial tissue diffusion and vascular dispersion on hepatic availability of drugs are compared. Vascular dispersion is of major importance to the availability of poorly diffusible compounds, whereas axial tissue diffusion becomes increasingly dominant for highly diffusive and partitioned substances.This study was supported by the National Health and Medical Research Council of Australia.  相似文献   
84.
门诊抗菌药物使用调查   总被引:2,自引:1,他引:1  
韩奇  项迎春 《中国药业》2007,16(18):47-48
目的了解医院门诊抗菌药物应用情况,为临床合理应用抗菌药物提供依据。方法抽查2006年1月至11月份门诊处方18163张,统计抗菌药物使用情况,并评价其合理性。结果含抗菌药物处方5809张,占总处方数31.98%。头孢菌素类药物使用率最高,其次为喹诺酮类。给药途径主要为口服给药。结论抗菌药物应用基本合理,但使用中存在一些问题,应引起重视。  相似文献   
85.
笔者结合单位的做法和体会,对医疗单位等在特殊药品使用管理中存在的问题,提出特殊药品的管理应法制化、职责化、程序化、档案化及提高业务素质、奖优罚劣的管理方法。  相似文献   
86.
桂枝汤各组分作用的比较   总被引:1,自引:0,他引:1  
以急性毒性、镇痛及体温降低作用为指标比较了桂枝汤及其组方中五味中药的作用。证实桂枝汤的镇痛作用主要由桂皮和芍药所致;降温作用主要因桂皮和甘草所致。在方剂中各味中药可产生协同效应。桂枝汤毒性主要由桂皮和甘草所致。方剂中各药的毒性均较单独用药降低。表明桂枝汤组方后各味中药的疗效增强而毒性降低。  相似文献   
87.
88.
The market of non-registered pharmaceutical products is growing fast in number and overall costs, not only in the Netherlands, but also in other European countries. These products often give the impression that the consumer may expect 'an effect as from a drug'. Legally, there is a clear distinction between 'drugs' and 'commodities' in the Netherlands; the question is whether legislation and practice concur. In an investigation we analysed texts of advertisements for non-registered pharmaceutical products published in a popular magazine. A method was developed, based on the legal definition of a drug and jurisprudence, to determine in a qualitative and quantitative way the application of medicinal claims. It transpired that in 65% of the analysed advertisements explicit or implicit claims were made. These products should therefore be subject to drugs legislation. Thus, in the Netherlands there is a gap between legislation and practice in advertising non-registered pharmaceutical products.  相似文献   
89.
手术配合局部外用药治疗慢性肛门湿疹临床观察   总被引:2,自引:0,他引:2  
目的:观察手术配合术后曲咪新加复方鱼肝油软膏混合膏局部换药治疗慢性肛门湿疹的疗效.方法:将93例慢性肛门湿疹患者随机分为治疗组(47例)和对照组组(46例),治疗组采用手术配合术后曲咪新加复方鱼肝油软膏混合膏局部换药,对照组采用亚甲蓝局部封闭配合术后皮炎平局部换药.观察两组患者术后长短期疗效.结果:治疗组短期有效率为93.61%,疗效优于对照组71.74%(P<0.01);治疗组远期有效率为89.36%,优于对照组60.87%(P<0.01).结论:本法治疗慢性顽固性肛门湿疹疗效确切、复发率低.  相似文献   
90.
目的:观察活血化瘀中药联合血管内皮生长因子(VEGF)基因转移对促进股骨头缺血坏死处新生血管形成情况。方法:日本大耳兔40只,随机分为对照组、模型组、中药组、基因组和综合组。治疗8周后采用免疫组织化学方法观察股骨头滑膜VEGF阳性细胞率及数字减影血管造影股骨头血管数目改变情况。结果:模型组VEGF阳性细胞表达率减低,与对照组、基因组、综合组比较,差异有显著性意义(P<0.01),与中药组比较,有统计学差异(P<0.05),综合组VEGF阳性细胞表达率较高,与中药组及基因组比较,有统计学差异(P<0.05)。血管数目:在A区,各组与模型组比较,均无统计学差异;在B区,各组较模型组血管数目均有增加,对照组、基因组、综合组与模型组比较,有统计学差异(P<0.05)。综合组与基因组比较有统计学差异(P<0.05),中药组虽然血管数目较模型组多,但是无统计学意义。结论:活血化瘀中药及VEGF基因转移均可促进股骨头缺血坏死处局部新生血管形成和侧支循环的建立,尤以活血化瘀中药联合基因疗法效果为好,为临床应用活血化瘀中药联合基因疗法治疗股骨头缺血性坏死提供实验依据。  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司    京ICP备09084417号-23

京公网安备 11010802026262号