Bilateral Buccal Bifurcation Cyst: Case Report and Literature Review

Buccal bifurcation cyst (BBC) is a rare inflammatory odontogenic cyst that typically occurs at the buccal region of the first or second mandibular molars of children. In the current case, a 9-year-old boy complained of an extraoral soft tissue painful swelling. Intraoral examination revealed a partial eruption of the right permanent mandibular first molar with drainage of purulent material and clinical absence of the left mandibular first molar. Panoramic radiographic and computed tomography showed two well-defined areas surrounding the mandibular first molars consistent with cystic lesions. Surgical enucleations were performed and histopathologic analysis revealed inflammatory cysts. Based on the clinical, microscopic, radiographic, and CT images, the diagnosis of bilateral BBC was established. Patient has been under follow-up for about 1 year showing normal bone repair and eruption of the involved teeth. Although BBC is uncommon, it is important to recognize this entity.     

口外弓配合唇档远移磨牙的临床研究

目的:研究口外弓配合唇档远移磨牙的临床应用及其疗效。方法:选择15例恒牙早期上颌轻度牙性前突或轻、中度拥挤的安氏II类患者,应用口外弓配合唇档,通过X线头影测量观察其上颌磨牙及前牙治疗前后变化情况。结果:应用口外弓配合唇档推磨牙向远中3～6个月后,II类咬合关系恢复至安氏I类关系。上颌第一磨牙向远中平均移动4.14mm,上颌中切牙向唇侧移动0.66mm。结论:只要病例选择合适,方法运用得当,口外弓配合唇档就能获得较满意的远移磨牙的疗效。     

Understanding human rhinovirus infections in terms of QSAR

The human rhinoviruses (HRVs) are the single most important cause of common colds. The widespread nature of this affliction, the economic consequences, and the well-known impracticality of vaccine development due to the large number of HRV serotypes (>100) have justified the search for chemotherapeutic agents. The interest in the application of quantitative structure-activity relationships has steadily increased in recent decades and we hope it may be useful in the search for anti-HRV agents. In the present paper, we have discussed the inhibition of various six compound series against HRV-1A, -1B, -2, -9, -14, -21, -22, -25, -64, and -89 by the formulation of a total number of 14 QSAR. Hydrophobicity is found to be one of the most important determinants of activity. Parabolic correlation with the hydrophobic parameter (Eq. ) is an encouraging example, where the optimal hydrophobicity is well defined. We believe that this may be the predictive model to narrow the synthetic challenges in order to yield very specific HRV-2 inhibitors. On the basis of this model, we have predicted eleven compounds (I-1 to I-11) that may be the next synthetic target. The proposed molecules (I-1 to I-11) also fulfill the conditions of Lipinski's "rule of five".     

Prediction of mandibular movement and its center of rotation for nonsurgical correction of anterior open bite via maxillary molar intrusion

Objectives:To evaluate quantitatively the relationship between molar intrusion (change [Δ] maxillary first molar [U6]–palatal plane [PP]) and changes in vertical and sagittal cephalometric parameters and to determine the center of mandibular autorotation.Materials and Methods:Twenty-one patients diagnosed with anterior open bite and successfully treated with molar intrusion (overbite [OB] > 0 mm) were retrospectively enrolled. Lateral cephalograms taken before and after molar intrusion were used to measure changes in vertical and sagittal cephalometric parameters. The center of mandibular autorotation was calculated by measuring displacement of gonion (Go) and pogonion (Pog). Paired t-tests were used to compare variables, and linear regression analysis was used to examine the relationship between ΔU6-PP and other variables.Results:The mandible exhibited counterclockwise rotation after maxillary molar intrusion, which led to closure of anterior open bite. Strong linear relationships, in descending order, between ΔU6-PP and ΔOB, Δanterior facial height (AFH), Δvertical reference plane (Pog), and Δsella-nasion to Go-menton (SN-GoMe), were observed. When the maxillary molar was intruded 1 mm, OB increased by 2.6 mm, AFH decreased by 1.7 mm, Pog moved forward by 2.3 mm, and SN-GoMe decreased by 2°. The center of mandibular autorotation was located 7.4 mm behind and 16.9 mm below condylion after molar intrusion.Conclusions:The mandible exhibited counterclockwise rotation after maxillary molar intrusion; the center of mandibular autorotation was located behind and below condylion with individual variations.     

Relationship between osteopathic manipulative treatment of the temporomandibular joint,molar shim and the orthostatic position: A randomized,controlled and double blinded study

This randomized, controlled, double-blinded study related the effect of osteopathic manipulative treatment (OMT) of the temporomandibular joint (TMJ) and the orthostatic posture using the molar shim (MS) as a postural adjustment factor. Twenty individuals classified with temporomandibular disorder (TMD) were randomly assigned to a treated group (TG, n = 10) and placebo (PG, n = 10). The independent variables were: MS and OMT of the TMJ. The dependent variables were: DC-TMD data; local pressure pain using algometry; and orthostatic posture assessed by the distribution of plantar pressures (baropodometry), in the evaluation periods before and immediately after the interventions. Results: pain did not show a statistically significant difference after the interventions. However, when comparing the Effect Size (ES) between the groups in the post-intervention moment, a moderate relationship was observed for the left trapezius muscle (0.51) and right and left TMJ (0.41 and 0.54 respectively). When correlating the pain and percentage of anteroposterior postural dislocation variables, a significant moderate inverse correlation was observed in the post-intervention moment. The results of the MS pointed to a significant decrease (p ≤ 0.05) of the average peak pressure (Medium P) during the use of the MS (503.4 ± 44.1 kgf/cm2) and after performing the OMT (516.5 ± 49.6 kgf/cm2), both for the TG compared to the pre intervention moment (519.3 ± 42.9 kgf/cm2). There is a correlation between TMJ and orthostatic posture. OMT of the TMJ influences orthostatic posture. The MS can be added to the evaluative context of TMD.     

新型镍钛机动器械预备磨牙根管的疗效评估

目的观察新型镍钛机动器械Her0642和protaper预备磨牙根管的临床疗效。方法选取有牙髓炎或根尖周炎的磨牙120颗392个根管,随机分为三组分别实验组A和实验组B,对照组。实验组A,实验组B分别采用Her0642和ProTaper机用镍钛器械使用冠根向预备技术进行根管预备;对照组采用标准不锈钢K锉,按逐步后退法预备根管。记录预备时间,评估预备后的并发症,比较治疗前后的X线片评价根管预备和充填效果。结果实验组的根管预备时间和术后疼痛的发生率明显少于对照组（P〈0．05）,实验组根充效果明显优于对照组（P〈0．05）,实验组的断针率明显高于对照组（P〈0．05）。结论机动镍钛器械预备根管效率高,根充效果好,术后并发症少,值得在临床上广泛推广。但断针率高,临床操作中应加于预防和改进。     

微钛板支抗在远中移动磨牙中的临床应用

目的介绍微钛板支抗在远中移动磨牙中的临床效果及特点。方法选择7名应用微钛板矫治患者,分析其治疗前后头颅侧位片、模型等临床资料,测量磨牙远中移动量。结果 1)利用微钛板远中移动磨牙效果明显,最多可达3.5mm。2)中轻度牙列拥挤患者利用微钛板远中移动磨牙获得间隙排齐整平牙列,不需拔除双尖牙便可达到较理想的治疗效果。结论微钛板作为一种绝对支抗,远中移动磨牙有效而稳定,同时可避免常规拔牙矫治,维持上下颌第二磨牙间的全部牙齿和牙弓的连续性。     

牛齿根解热、镇静、抗惊厥作用研究

新鲜老黄牛颚牙根制配成0.2g/ml 混悬剂,家兔以伤寒三联菌苗致热,体温升高1℃时分别以混悬剂、柴胡液及助悬剂灌胃,150min 牛齿根组兔温39.2±0.5,柴胡组38.5±0.4,对照组39.9±0.4。牛齿根灌胃,抖笼实验及滚棒实验,小鼠活动减少,反应迟钝,协调运动差;能延长戊巴比妥钠致小鼠的睡眠(牛齿根组108±5.1sec,对照组96.2±3.6sec),对抗戊四氮的致惊厥作用。认为动物实验符合临床牛齿根治疗小儿热病惊厥作用,机制值得进一步探讨。     

磨牙牙根发育模式基因1在大鼠多脏器中的表达及其结构分析

目的 了解磨牙牙根发育模式基因1(molar root patterning gene l,Mrpl)的组织表达特征并对其结构进行预测、分析,从而为进一步研究磨牙牙根发育模式基因1的功能奠定基础.方法 通过反转录聚合酶链反应(RT-PCR)方法对Mrpl基因的表达情况进行研究,并通过染色体分析、基因组定位及其他生物信息学手段对该基因进行结构分析.结果 经RT-PCR检测发现,Mrpl mRNA除了在大鼠磨牙牙胚组织表达外,在发育中的胰、肝、肺、肾组织中也有表达;生物信息学分析显示,Mrpl定位于大鼠18号染色体长臂18q12.3区,且Mrpl蛋白序列同尿道上皮细胞分化标志膜蛋白Uroplakin Ⅲb(p35)有37%的同源性,跨膜区分析及序列疏水性分析都印证了Mrpl蛋白质序列的第10～40位氨基酸间有一段跨膜序列及疏水区域.结论 Mrpl基因编码产物可能是c端带有多个磷酸化位点的跨膜蛋白,且在多个脏器的发育中可能具有一定的生物学意义,值得进一步研究.