我国交通运输设备制造业科技投入竞争力研究 --以大中型工业企业为案例的分析

交通运输设备制造业的竞争力,在很大程度上代表了一个国家或一个地区制造业的水平。其中科技投入是重要决定因素。本文以大中型工业企业为案例,实证研究了我国交通运输设备制造业科技投入竞争力建设的行业特征、地区特征和存在问题,为我国机电产业科技竞争力提升提供决策依据。     

基于多维空间的商务协同要素分析

运用四维空间分析方法,引入时间压缩策略、战略成本管理、标杆管理和协同效应等原理,将网络协同商务链置于时间维、经济成本维、性能维和可持续发展维等多维空间中进行多元素分析和运筹。指出企业间资源、信息与业务的协同能力依赖于时间、成本、性能以及持续竞争优势等多个约束因素的协调。     

一种实用的新型高压无线核相装置的设计

提出了一种无线方式对高压线路不同相之间的相位进行间接检测的新方法,该方法主要利用无线电理论．电磁波在天线电感线圈上可以感应出相应电动势的原理,并利用串联谐振电路和窗口比较器等电路实现对相位进行采集。发送装置将具有相位信息的信号调制后通过无线方法发送到接收装置,接收装置通过解调和比较电路测量出了两条被测线路之间的相位差,实现了对高压线路相位的检测。     

推进绿色转型 打造最具竞争力钢铁企业

钢铁企业实施绿色转型,对企业实现可持续发展,提升市场竞争力,赢得生存空间等具有重要意义。通过总结唐钢绿色转型发展采取的措施和取得的成效,指出企业实施低碳发展和绿色转型能够获得丰厚的回报;低碳发展、绿色转型是一个不断发展和提升的过程;持续改善、追求卓越是企业不断挖掘内部潜力、实现健康发展的动力源泉。     

冶炼烟气制酸净化改造

介绍了韶冶一硫酸净化工序技术改造和运行情况．改造采用了三塔（空塔、动力波、填料塔）、两电和冷凝器间接冷却烟气移热流程．改造后生产工艺稳定,净化效率大大提高．     

服务规则约束下B2C平台企业竞争策略

基于服务规则约束机制的策略已成为B2C电子商务平台获取竞争优势重要手段之一。在双边市场理论模型基础上,分别建立了垄断和寡头竞争情形的B2C平台Hotelling竞争模型,比较分析了买方多归属卖方单归属和买卖双方多归属情形下竞争性B2C平台服务规则约束机制的最优策略。通过研究发现,垄断B2C平台下,平台企业和卖方企业都没有提高服务规则约束力度的意愿;在买方多归属卖方单归属时,卖方企业运作和维护服务规则约束机制更能提高用户体验和提高B2C平台绩效;在买卖双方多归属时,平台企业运作和维护服务规则约束机制更为有利。     

Indirect Immobilised Jagged-1 Enhances Matrisome Proteins Associated with Osteogenic Differentiation of Human Dental Pulp Stem Cells: A Proteomic Study

The indirect immobilisation of Jagged-1 (Jagged-1) promoted osteogenic differentiation of human dental pulp cells (hDPs). Furthermore, the analysis of the Reactome pathway of RNA sequencing data indicates the upregulated genes involved with the extracellular matrix (ECM). Hence, our objective was to investigate the effects of Jagged-1 on proteomic profiles of human dental pulp stem cells (hDPSC). hDPSCs were cultured on the surface coated with human IgG Fc fragment (hFc) and the surface coated with rhJagged1/Fc recombinant protein-coated surface. Cells were differentiated to the osteogenic lineage using an osteogenic differentiation medium (OM) for 14 days, and cells cultured in a growth medium were used as a control. The protein component of the cultured cells was extracted into the cytosol, membrane, nucleus, and cytoskeletal compartment. Subsequently, the proteomic analysis was performed using liquid chromatography–tandem mass spectrometry (LC-MS). Metascape gene list analysis reported that Jagged-1 stimulated the expression of the membrane trafficking protein (DOP1B), which can indirectly improve osteogenic differentiation. hDPSCs cultured on Jagged-1 surface under OM condition expressed COL27A1, MXRA5, COL7A1, and MMP16, which played an important role in osteogenic differentiation. Furthermore, common matrisome proteins of all cellular components were related to osteogenesis/osteogenic differentiation. Additionally, the gene ontology categorised by the biological process of cytosol, membrane, and cytoskeleton compartments was associated with the biomineralisation process. The gene ontology of different culture conditions in each cellular component showed several unique gene ontologies. Remarkably, the Jagged-1_OM culture condition showed the biological process related to odontogenesis in the membrane compartment. In conclusion, the Jagged-1 induces osteogenic differentiation could, mainly through the regulation of protein in the membrane compartment.     

Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides

Mycothiol (MSH), the major cellular thiol in Mycobacterium tuberculosis (Mtb), plays an essential role in the resistance of Mtb to various antibiotics and oxidative stresses. MshC catalyzes the ATP-dependent ligation of 1-O-(2-amino-2-deoxy-α-d-glucopyranosyl)-d-myo-inositol (GlcN-Ins) with l-cysteine (l-Cys) to form l-Cys-GlcN-Ins, the penultimate step in MSH biosynthesis. The inhibition of MshC is lethal to Mtb. In the present study, five new cysteinyl-sulfonamides were synthesized, and their binding affinity with MshC was evaluated using a thermal shift assay. Two of them bind the target with EC₅₀ values of 219 and 231 µM. Crystal structures of full-length MshC in complex with these two compounds showed that they were bound in the catalytic site of MshC, inducing dramatic conformational changes of the catalytic site compared to the apo form. In particular, the observed closure of the KMSKS loop was not detected in the published cysteinyl-sulfamoyl adenosine-bound structure, the latter likely due to trypsin treatment. Despite the confirmed binding to MshC, the compounds did not suppress Mtb culture growth, which might be explained by the lack of adequate cellular uptake. Taken together, these novel cysteinyl-sulfonamide MshC inhibitors and newly reported full-length apo and ligand-bound MshC structures provide a promising starting point for the further development of novel anti-tubercular drugs targeting MshC.     

钛铁矿浮选中的抑制剂研究

钛铁矿的浮选近年来受到极大关注,但对浮选药剂的研究多集中在捕收剂上,对抑制剂的研究相对较少。常用抑制剂有水玻璃、羧甲基纤维素和草酸等。本研究对比了多种抑制剂在钛铁矿浮选中对脉石的抑制效果以及对钛铁矿的分选性,并进行了系统的单矿物试验,最终证明对钛铁矿浮选而言,羧甲基纤维素是现有抑制剂中最为有效的,同时对羧甲基纤维素的抑制机理进行了探讨,认为竞争吸附很有可能是羧甲基纤维素在钛铁矿浮选中对脉石具有良好抑制效果的原因。     

铝及铝合金反向挤压(2)

介绍了金属反向挤压法的基本原理、特点、主要分类、反向挤压生产中应注意的技术、质量问题和主要经济指标。介绍了国内50MN反向挤压机挤压生产工艺,反向挤压时金属流动特性,制品的组织、性能及尺寸精度,现代反向挤压设备的主要特点（如铸锭表面切屑加工、铸锭梯度加热与排气、穿孔针拉力显示与保护、过程信息与控制系统、挤压机中心精度控制技术等）,铝及铝合金管、棒、型材的反向挤压生产工艺。