The “Angiogenic Switch” and Functional Resources in Cyclic Sports Athletes

Regular physical activity in cyclic sports can influence the so-called “angiogenic switch”, which is considered as an imbalance between proangiogenic and anti-angiogenic molecules. Disruption of the synthesis of angiogenic molecules can be caused by local changes in tissues under the influence of excessive physical exertion and its consequences, such as chronic oxidative stress and associated hypoxia, metabolic acidosis, sports injuries, etc. A review of publications on signaling pathways that activate and inhibit angiogenesis in skeletal muscles, myocardium, lung, and nervous tissue under the influence of intense physical activity in cyclic sports. Materials: We searched PubMed, SCOPUS, Web of Science, Google Scholar, Clinical keys, and e-LIBRARY databases for full-text articles published from 2000 to 2020, using keywords and their combinations. Results: An important aspect of adaptation to training loads in cyclic sports is an increase in the number of capillaries in muscle fibers, which improves the metabolism of skeletal muscles and myocardium, as well as nervous and lung tissue. Recent studies have shown that myocardial endothelial cells not only respond to hemodynamic forces and paracrine signals from neighboring cells, but also take an active part in heart remodeling processes, stimulating the growth and contractility of cardiomyocytes or the production of extracellular matrix proteins in myofibroblasts. As myocardial vascularization plays a central role in the transition from adaptive heart hypertrophy to heart failure, further study of the signaling mechanisms involved in the regulation of angiogenesis in the myocardium is important in sports practice. The study of the “angiogenic switch” problem in the cerebrovascular and cardiovascular systems allows us to claim that the formation of new vessels is mediated by a complex interaction of all growth factors. Although the lungs are one of the limiting systems of the body in cyclic sports, their response to high-intensity loads and other environmental stresses is often overlooked. Airway epithelial cells are the predominant source of several growth factors throughout lung organogenesis and appear to be critical for normal alveolarization, rapid alveolar proliferation, and normal vascular development. There are many controversial questions about the role of growth factors in the physiology and pathology of the lungs. The presented review has demonstrated that when doing sports, it is necessary to give a careful consideration to the possible positive and negative effects of growth factors on muscles, myocardium, lung tissue, and brain. Primarily, the “angiogenic switch” is important in aerobic sports (long distance running). Conclusions: Angiogenesis is a physiological process of the formation of new blood capillaries, which play an important role in the functioning of skeletal muscles, myocardium, lung, and nervous tissue in athletes. Violation of the “angiogenic switch” as a balance between proangiogenic and anti-angiogenic molecules can lead to a decrease in the functional resources of the nervous, musculoskeletal, cardiovascular, and respiratory systems in athletes and, as a consequence, to a decrease in sports performance.     

Highly Thermal Stable Polyimides Applied in Flexible Resistive Memory

Flexible memory devices are one of the most crucial elements in the wearable electronics. In this work, polyimides (PIs)-based flexible resistive memory devices with an excellent thermal and mechanical durability are demonstrated. Four kinds of functional PIs are derived from the heterocyclic diamines including 2,6-diaminodibenzo-p-dioxin (OODA) and 2,6-diaminothianthrene, and dianhydrides including 4,4′-(hexafluoroisopropylidene)diphthalic anhydride (6FDA) and 3,3′,4,4′-biphenyltetracarboxylic dianhydride. PI with diamine of OODA and dianhydride of 6FDA (PI(OODA_6FDA)) possesses outstanding thermal and mechanical properties with a high glass transition temperature of 352 °C, a low coefficient of thermal expansion of 28.1 ppm K⁻¹, and a high elongation at break of 10%. In addition, PI(OODA_6FDA)-based memory shows write-once-read-many behavior with a high on/off current ratio of 10⁶ and a stable data retention, attributed to the donor–acceptor charge transfer between the polymer chains. The retained current levels at a low resistive state can be observed even with thermal treatment at 200 °C for 24 h or 1000 times cyclic bending at a bending radius of 5 mm. These results demonstrate the potential of heterocyclic PIs for flexible resistive memory.     

160 t钢包翻包机结构与功能

新型钢包翻包机是九十年代从国外引进的一种专用设备,其以高效、安全、便捷等特点越来越多的应用于大型钢铁厂.本文介绍了160 t翻包机结构与功能.     

水下隧道穿越管道保护效果测试评价

本文通过对四川气田北干线涪江隧道穿越管道阴极保护电参数的现场测试，取得了实际可信的基础数据，验证了处于水下隧道洞内的穿越段管道，能得到陆上强制电流阴极保护系统的有效保护，保护电流所必经的岩石层和锚喷钢筋混凝土层对保护电流没有构成屏蔽的结论，对管道工程设计和运行管理具有指导作用。     

Nickel Electroplating

NICKEL ELECTROPLATING has been practicallyused for decades.There is an unknown part in theplating,although this is easy to plate.Applications ofthe plating are described from the practical viewpoint.Purpose of Nickel Electroplating(1)Decorative,and corrosion resistanceNickel electroplating is deposited on iron,cupper,zinc and aluminum substrate etc.,and chromiumplating is usually deposited on nickel plating.Hexavalent chromium plating has an important effecton the corrosion resisitan…     

Output controllability and optimal output control of state-dependent switched Boolean control networks

In the present paper, we investigate the output-controllability and optimal output control problems of a state-dependent switched Boolean control network. By using the semi-tensor product, the algebraic form of the system is obtained. Then, output-controllability problems of the system are discussed and some necessary and sufficient conditions are given. Next, the Mayer-type optimal output control issue is considered and an algorithm is provided to find out the control sequence. At last, an example is given to show the effectiveness of the main results.     

软件定义网络中交换机处理时延的仿真

针对目前的网络仿真工具在对软件定义网络(SDN)的仿真过程中,未考虑交换机的处理时延的问题,提出一种处理时延的仿真方法,目的是为了使仿真结果更加真实和准确。该方法首先将交换机的转发处理过程分解为对流表的查询操作和执行不同的动作;然后,利用交换机的处理器频率和访存周期,将查询流表和执行动作转换为处理时间。实验中测量了真实环境中不同配置的交换机处理时延,并与利用该方法仿真出的处理时延进行对比。实验结果表明,利用该方法仿真出的处理时延和真实交换机的处理时延基本一致,该方法能够较准确地仿真交换机处理时延。     

基于带缓冲的双通道开关技术的网络隔离器设计

在对网络隔离技术进行分析的基础上,研究利用网络隔离技术来解决网络安全问题。目前的网络隔离产品大多是采用基于硬件的开关控制,受限于现有硬件技术条件,并且厂家要根据不同用户要求而开发生产针对特定应用的网闸,不能方便地同时支持多种应用。提出了一种改进的安全隔离网闸实现方案。重点是模块化和软件方式实现开关技术,采用独立的软件开关控制和模块化设计,解决了现有物理隔离网闸产品在硬件开关控制和所支持应用上的限制,这种采用软件实现开关功能的方式避免基于现有硬件技术的可用性和寿命时间的限制。     

程控多路宽电压通道切换电路设计

为克服传统校验方法的不足,简化自动化测试设备的面板设计和校验过程,基于单片机技术和RS-422通信接口,设计了一种程控多路宽电压通道切换电路。介绍了电路工作原理、元器件选择、软硬件设计过程。该电路已经在多台测试设备的校验环节得到应用,工作性能稳定。     

乙酸乙酯与乙酸正丙酯的切换式连续生产

作者在对乙酸乙酯、乙酸异丙酯、乙酸正丙酯和乙酸丁酯的现有生产工艺进行分析后,以乙酸乙酯和乙酸正丙酯为研究对象,在以往对两者研究的基础上,提出了乙酸乙酯与乙酸正丙酯切换式连续生产的工艺流程,并且通过模拟计算和小试验证证明,在同样的生产装置上,可以分别连续生产乙酸乙酯和乙酸正丙酯,采用该工艺生产乙酸乙酯能耗低于传统工艺12%,生产乙酸正丙酯比原有工艺可以提高收率2%。