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101.
Increased androgen receptor gene copy number is associated with TMPRSS2‐ERG rearrangement in prostatic small cell carcinoma 
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下载免费PDF全文 102.
《Ocular immunology and inflammation》2013,21(4):322-323
Purpose: To report a case of autoimmune retinopathy (AIR) associated with a thyroid carcinoma.Design: Case report.Method: A 51-year-old Caucasian woman presented with a rapid decline in vision. Initial visual field and immunohistochemical testing revealed autoimmune retinopathy without an apparent underlying malignancy. Conventional local and systemic immunosuppressive therapies failed to halt the progression.Results: Rituximab treatments were initiated and a slowing of visual loss was seen. Continued surveillance for malignancy revealed a thyroid adenoma, and later a thyroidectomy revealed a thyroid carcinoma.Conclusions: This report highlights the unique presentation of AIR associated with a thyroid carcinoma, the need for continued surveillance for malignancy in cases of AIR, and the possible new use of rituximab for the treatment of AIR. 相似文献
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PurposeTo evaluate the association between choriocapillary flow (CCF) and electroretinogram (ERG) in patients with diabetes.MethodThis was a cross-sectional study. Patients with type 2 diabetes and healthy controls who had undergone both flicker ERG and optical coherence tomography angiography (OCTA) were included, while patients with severe diabetic retinopathy (DR) and macular edema were excluded. Correlations among OCTA and ERG parameters were conducted by generalized linear mixed models (GLMM).ResultOne hundred ninety-four eyes of 102 patients with diabetes and fifty-six eyes of 28 controls were included. The implicit time of 30-Hz flicker ERG successively increased, while the amplitudes, inner-retina vessel density and CCF were decreased from the control to the nondiabetic retinopathy (NDR) to DR group. In patients with diabetes, all GLMM models of ERG parameters had statistically significance (P<0.05), and CCF was correlated with ERG parameters (coefficient index=-0.601, P< 0.001 with 16 Td-s implicit time; coefficient index=-0.687, P< 0.001 with 32 Td-s implicit time; coefficient index=0.933, P=0.035 with 32 Td-s amplitude) and the thickness of retinal pigment epithelium, while in the GLMM model of CCF, it was correlated with the thickness of retinal pigment epithelium and the level of glycosylated hemoglobin(both P= 0.001).ConclusionCCF decreased in patients with diabetes, and it was related with ERG. Choroidopathy and its functional impairment in the retina may occur very early in patients with diabetes by influencing the outer retina. 相似文献
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《Journal de Mycologie Médicale》2019,29(4):303-309
BackgroundEmergence of fluconazole resistance mediated by L321F mutation in the ERG11 gene poses a serious impediment in the candidal treatment process. This leads to the search of novel target proteins to develop newer drugs against fluconazole resistant C. albicans. The present investigation is thus aimed to explore the inhibitory potential of bioactive compounds from A. nilotica against the wild and mutated ERG11 gene of C. albicans.Materials and methodsHomology modelling of the wild and mutated ERG11 target gene was done by Modeller 9.2, with SDM I-mutant form of ERG11 together with SAVES server and Ramachandran plot validation. 2D and 3D structures of the bioactive compounds from A. nilotica were optimized by ACD chemsketch. Molinspirational assessments for the molecular properties of the ligands and their drug likeliness were estimated. In silico inhibitory potential of the selected ligands against wild and mutated ERG11 was done by AutoDock 2.0 and was visualized with Accelrys discovery studio tool.ResultsApigenin proved to be the best candidate to target mutant ERG11 with a binding energy of −8.33 Kcal/mol followed by catechin with six hydrogen bonds with more drug likeliness. Molinspiration assessments showed zero violations for all the bioactive compounds from A. nilotica and the TPSA scores of the ligands showed the values < 140 Å towards the best oral bio-availability.ConclusionThe findings of the study emphasize that kaempferol, apigenin and catechin from A. nilotica seem to possess a promising inhibitory effect against the wild and mutated ERG11 of C. albicans suggesting ERG11 as the best target to combat fluconazole resistant C. albicans with further in vivo validation targeting the same. 相似文献
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Calcium plays important roles in the function and survival of rod and cone photoreceptor cells. Rapid regulation of calcium in the outer segments of photoreceptors is required for the modulation of phototransduction that drives the termination of the flash response as well as light adaptation in rods and cones. On a slower time scale, maintaining proper calcium homeostasis is critical for the health and survival of photoreceptors. Decades of work have established that the level of calcium in the outer segments of rods and cones is regulated by a dynamic equilibrium between influx via the transduction cGMP-gated channels and extrusion via rod- and cone-specific Na+/Ca2+, K+ exchangers (NCKXs). It had been widely accepted that the only mechanism for extrusion of calcium from rod outer segments is via the rod-specific NCKX1, while extrusion from cone outer segments is driven exclusively by the cone-specific NCKX2. However, recent evidence from mice lacking NCKX1 and NCKX2 have challenged that notion and have revealed a more complex picture, including a NCKX-independent mechanism in rods and two separate NCKX-dependent mechanisms in cones. This review will focus on recent findings on the molecular mechanisms of extrusion of calcium from the outer segments of rod and cone photoreceptors, and the functional and structural changes in photoreceptors when normal extrusion is disrupted. 相似文献
