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排序方式: 共有249条查询结果,搜索用时 31 毫秒
71.
Razieh Salehi Ashani Homa Azizian Nahid Sadeghi Alavijeh Vaezeh Fathi Vavsari Shabnam Mahernia Niloofar Sheysi Mahmood Biglar Massoud Amanlou Saeed Balalaie 《化学与生物多样性》2020,17(5)
A series of new deferasirox derivatives were synthesized through the reaction of monosubstituted hydrazides with 2‐(2‐hydroxyphenyl)‐4H‐benzo[e][1,3]oxazin‐4‐one. For the first time, deferasirox and some of its derivatives were evaluated for their in vitro inhibitory activity against Jack bean urease. The potencies of the members of this class of compounds are higher than that of acetohydroxamic acid. Two compounds, bearing tetrazole and hydrazine derivatives (bioisoester of carboxylate group), represented the most potent urease inhibitory activity with IC50 values of 1.268 and 3.254 μm , respectively. In silico docking studies were performed to delineate possible binding modes of the compounds with the enzyme, urease. Docking analysis suggests that the synthesized compounds were anchored well in the catalytic site and extending to the entrance of binding pocket and thus restrict the mobility of the flap by interacting with its crucial amino acid residues, CME592 and His593. The overall results of urease inhibition have shown that these target compounds can be further optimized and developed as a lead skeleton for the discovery of novel urease inhibitors 相似文献
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73.
Mousavi Mina Mehrzad Jamshid Najafi Mohsen Fathi Zhiani Rahele Shamsian Seyed Ali Akbar 《Journal of applied phycology》2022,34(5):2271-2281
Journal of Applied Phycology - Nitrogen plays a key role in the production of biomass and valuable pigments from Arthrospira platensis. The present research aimed to examine the effect of Zarrouk... 相似文献
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75.
Boubakri Hatem Saidi Mohammed Najib Barhoumi Fathi Kamoun Hanen Jebara Moez Brini Faiçal 《Plant Molecular Biology Reporter》2019,37(5-6):464-476
Plant Molecular Biology Reporter - Key message: Thioredoxin h-type isoforms are tissue-specific, differentially expressed in germinating seeds and under salinity stress and highly regulated by... 相似文献
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77.
Abdalla A. Elbashir Nuha Fathi Ali Dsugi Tamador Omer Mohamoud Mohmed Hassan Y. Aboul‐Enein 《Luminescence》2014,29(1):1-7
Cyclodextrins (CDs) are a family of cyclic oligosaccharides composed of α‐(1,4)‐linked glucopyranose subunits. The most important feature of CDs is their ability to form inclusion complexes (host–guest complexes) with a very wide range of solid, liquid and gaseous compounds by a molecular complexation. During the last decade, a considerable number of research papers has been focused on the use of CDs to enhance fluorescence intensity of different analytes and to develop CD‐induced spectrofluorimetric method. In this review, the various spectrofluorimetric methods based on host–inclusion complex are presented. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
78.
Seyed Ali Asghar Fathi Maryam Bozorg-Amirkalaee Rana M. Sarfraz Hoshang Rafiee-Dastjerdi 《BioControl》2012,57(1):49-59
The diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae), is one of the most economically significant pests of canola, Brassica napus L., in Ardabil region, Iran. Use of host plant resistance integrated with biocontrol agents such as Diadegma majale (Gravenhorst) (Hymenoptera: Ichneumonidae) is an essential component of integrated management of P. xylostella. In this study, we investigated the parasitism by D. majale on six selected cultivars of canola under field conditions and preference and performance of the parasitoid on P. xylostella larvae under laboratory conditions. In field experiments, the highest larval density of P. xylostella was observed on Zarfam during 2008 and 2009. Larval densities were not significantly different among Opera, Hyola 401, Okapi,
and Option 500 and Elite in 2008, but the lowest larval density was observed on Opera in 2009. No significant differences
were observed among the rate of parasitized larvae on tested cultivars in 2008, while in 2009 the parasitism rate was significantly
higher on Opera than on Zarfam. In free-choice situations, the percentage of parasitized larvae was significantly highest
on Opera (88.7%) and lowest on Zarfam (62.95%). Developmental time from egg to adult, body mass, length of forewings and hindwings,
length of hind femur and hind tibia of D. majale females reared on larvae of P. xylostella fed on Opera did not differ from other cultivars. Our results suggest that cultivation of Opera integrated with D. majale could provide effective and sustainable management of P. xylostella in the region. 相似文献
79.
Mehri S Mahjoub S Hammami S Zaroui A Frih A Betbout F Mechmeche R Hammami M 《Molecular biology reports》2012,39(4):4059-4065
Essential hypertension (HTA) is the clinical expression of a disordered interaction between the genetic, physiological, and
biochemical systems that under usual conditions maintain cardiovascular homeostasis. We studied the effects of the angiotensinogen
M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms
on the risk of HTA and to evaluate the relationship between these polymorphisms and obesity. We performed AGT, ACE and AGTR
genotyping in 142 hypertensive patients and 191 control subjects using PCR-RFLP methods and PCR, respectively. The three polymorphisms
were significantly associated with HTA. Individuals carrying the mutated TT of AGT, DD of ACE and CC of AT1R genotypes had
an 1.67 (P = 0.032), 3.09 (P < 0.001) and 3.45 (P < 0.001)-fold increased risk of HTA. After adjustment for sex, smoking, diabetes, dyslipidemia, BMI, triglycerides and DD,
TT and CC genotypes, BMI was independent risk factor of HTA (OR = 3.14; P < 0.001). An association of BMI with ACE gene polymorphism (P = 0.035), whereas no association with AGT and AT1R gene polymorphisms was obtained. The proportion of hypertensives is as
high as 21.8 and 13.4% in the overweight and the obese DD group. The present study implies that the genotyping for the variants
of RAS gene could in the future become an important part of the clinical process of risk identification for HTA. 相似文献
80.
ABSTRACT: BACKGROUND: To study the diagnosis delay and its impact on stage of disease among women with breast cancer on Libya METHODS: 200 women, aged 22 to 75 years with breast cancer diagnosed during 2008--2009 were interviewed about the period from the first symptoms to the final histological diagnosis of breast cancer. This period (diagnosis time) was categorized into 3 periods: <3 months, 3--6 months, and >6 months. If diagnosis time was longer than 3 months, the diagnosis was considered delayed (diagnosis delay). Consultation time was the time taken to visit the general practitioner after the first symptoms. Retrospective preclinical and clinical data were collected on a form (questionnaire) during an interview with each patient and from medical records. RESULTS: The median of diagnosis time was 7.5 months. Only 30.0% of patients were diagnosed within 3 months after symptoms. 14% of patients were diagnosed within 3--6 months and 56% within a period longer than 6 months. A number of factors predicted diagnosis delay: Symptoms were not considered serious in 27% of patients. Alternative therapy (therapy not associated with cancer) was applied in 13.0% of the patients. Fear and shame prevented the visit to the doctor in 10% and 4.5% of patients, respectively. Inappropriate reassurance that the lump was benign was an important reason for prolongation of the diagnosis time. Diagnosis delay was associated with initial breast symptom(s) that did not include a lump (p < 0.0001), with women who did not report monthly self examination (p < 0.0001), with old age (p = 0.004), with illiteracy (p = 0.009), with history of benign fibrocystic disease (p = 0.029) and with women who had used oral contraceptive pills longer than 5 years (p = 0.043). At the time of diagnosis, the clinical stage distribution was as follows: 9.0% stage I, 25.5% stage II, 54.0% stage III and 11.5% stage IV.Diagnosis delay was associated with bigger tumour size (p <0.0001), with positive lymph nodes (N2, N3; p < 0.0001), with high incidence of late clinical stages (p < 0.0001), and with metastatic disease (p < 0.0001). CONCLUSIONS: Diagnosis delay is very serious problem in Libya. Diagnosis delay was associated with complex interactions between several factors and with advanced stages. There is a need for improving breast cancer awareness and training of general practitioners to reduce breast cancer mortality by promoting early detection. The treatment guidelines should pay more attention to the early phases of breast cancer. Especially, guidelines for good practices in managing detectable of tumors are necessary. 相似文献