The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier.     

运用试验设计法优化某军品压铸弹尾工艺

根据某军品部件出现的问题，应用试验设计法成功地找出了最优组合，提高了该部件的强度，解决了该强度问题，使生产得以正常进行。     

Reconsideration on Homogeneous Quadratic Riemann Boundary Value Problem

The homogeneous quadratic Riemann boundary value problem (1) with Hoelder continuous coefficients for the normal case was considered by the author in 1997. But the solutions obtained there are incomplete. Here its general method of solution is obtained.     

Abrupt climate change：Debate or action

Global abrupt climate changes have been documented by various climate records, including ice cores, ocean sediment cores, lake sediment cores, cave deposits, loess deposits and pollen records. The climate system prefers to be in one of two stable states, i.e. interstadial or stadial conditions, but not in between. The transition between two states has an abrupt character. Abrupt climate changes are, in general, synchronous in the northern hemisphere and tropical regions. The timescale for abrupt climate changes can be as short as a decade. As the impacts may be potentially serious, we need to take actions such as reducing CO2 emissions to the atmosphere.     

The Optimal Solution of the Model with Physical and Human Capital Adjustment Costs

We prove that the model with physical and human capital adjustment costs has optimal solution when the production function is increasing return and the structure of vetor fields of the model changes substantially when the prodution function from decreasing return turns to increasing return. And it is shown that the economy is improved when the coefficients of adjustment costs become small.     

经常购买模型及其参数的极大似然估计

在分析巴斯模型和重复购买的产品生命周期模型等的基础上，提出经常购买模型，详细讨论该模型的参数的极大似然估计法，并采用实例检验模型及参数估计方法，分析模型的参数估计结果，在此基础上使用模型做产品销量预测，表明模型的参数估计方法及预测方法的有效性。     

ZD15振动机除铁原理

去除粉状耐火材料、玻璃原料、电瓷物料中的铁磁物质，目前工业上普遍采用酸洗法。但该法生产周期长，效率低，成本高。而振动电磁除铁不但可快速、高效、低耗地除去这类物料中的铁磁杂质，且操作简便。本文给出了所设计的除铁器的振幅、生产率及振体空间在励磁回路中所需的磁感应强度等基本设计参数，为结构设计提供了理论依据     

论社会主义民主发展道路和指导原则：学习邓小平社会主义民主建设思想

邓小平提出民族制度化、法律化思想，为我国民主建设健康发展提出了一条正确的发展道路。民主制度化、法律化的实践，有效地保障了人民民主权利，规范了人民行使民主权利的行为，使建设法治国家目标的实现了可靠的保证。为使我国民主建设实践在正确道路上顺利前进，邓小平还提出一系列的指导原则，强调社会主义民主建设，必须在共产党的领导下，有秩序地进行；必须从国情出发，切合中国实际；必须保证国家兴旺发达和长治久安。     

Static extracting method of software intended behavior based on API functions invoking

The method of extracting and describing the intended behavior of software precisely has become one of the key points in the fields of software behavior＇s dynamic and trusted authentication. In this paper, the author proposes a specified measure of extracting SIBDS （software intended behaviors describing sets） statically from the binary executable using the software＇s API functions invoking, and also introduces the definition of the structure used to store the SIBDS in detail. Experimental results demonstrate that the extracting method and the storage structure definition offers three strong properties： （i） it can describe the software＇s intended behavior accurately; （ii） it demands a small storage expense; （iii） it provides strong capability to defend against mimicry attack.     

Comparison of Drought-Resistance about Three Wild Rocky-Grasses

In this experiment, using the methods of drought-stress in the pot and PEG simulative drought-stress, three native rocky-slope grasses Pogonatherum panideum（Lam.） Hack, Erioophorum comosum nees and Cynodon dactylon cultivated in the pots were selected as materials to study their drought-resistance by analyzing the indexes such as the leaf area index, the drying roots accumulation, the holding water ability of leaf, the relative conductance of leaf, the soluble protein, chlorophyll. At the same time, by comparing with membership function value of each index, the order of each grass drought-resistance was decided. The results showed that the drought-resistance of Erioophorum comosum nees was stronger than Cynodon dactylon and drought-resistance of Cynodon dactylon was stronger than Pogonatherum panideum （Lam.） Hack. The purpose of the experimental results was to find theoretical foundations for selecting and cultivating native protecting-slope vegetations to adapt to rocky slopes.