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91.
Bioassay-guided fractionation of the root wood of Zanthoxylum wutaiense led to the isolation of 11 new compounds, wutaiensol methyl ether (1), demethoxywutaiensol methyl ether (2), methyl wutaiensate (3), methyl 7-hydroxyanodendroate (4), methyl 7-methoxyanodendroate (5), wutaifuranol (6), 7-methoxywutaifuranol (7), 7-methoxywutaifuranal (8), methyl wutaifuranate (9), methyl 7-methoxybenzofuran-5-carboxylate (10), and wutaipyranol (12), together with another 37 known compounds, of which one, 7-methoxybenzofuran-5-carboxaldehyde (11), was not previously known as a plant constituent. The structures of these isolates were identified by means of spectroscopic analysis. Five of these isolates were found to be antitubercular constituents, namely, methyl 7-methoxyanodendroate (5), 7-methoxywutaifuranal (8), wutaiensal (13), dictamnine (14), and gamma-fagarine (15), which exhibited antitubercular activity against Mycobacterium tuberculosis H37Rv, showing MIC values of 35, 35, 30, 30, and 30 microg/mL, respectively. 相似文献
92.
93.
Kagami M Nagai T Fukami M Yamazawa K Ogata T 《Journal of assisted reproduction and genetics》2007,24(4):131-136
Purpose: The prevalence of low birth weight (LBW) is increased in subjects born after assisted reproduction technology (ART), and
defective imprinting has frequently been identified in patients with Beckwith-Wiedermann and Angelman syndromes conceived
by ART. Thus, we examined methylation pattern in a girl born after ART who had Silver-Russell syndrome (SRS) which can be
caused by maternal uniparental disomy for chromosome 7 and by hypomethylation of the differentially methylated region (DMR)
of H19.
Methods: We examined methylation status of 31 cytosines at the CpG dinucleotides in the DMR of PEG1/MEST on 7q32.2 and 23 cytosines at the CpG dinucleotides in the DMR of H19 on 11p15, using leukocyte genomic DNA.
Results: Eight of the 31 cytosines in the patient and four of the 31 cytosines in the father were hypermethylated in the PEG1/MEST-DMR. In the H19-DMR, no abnormal methylation pattern was identified in the patient.
Conclusion: The results suggest that hypermethylation of paternally expressed genes including PEG1/MEST, which usually have growth-promoting effects, may be relevant to LBW in subjects conceived by ART.
Partial hypermethylation was identified at the differentially methylated region of paternally expressed PEG1/MEST in a girl with Silver-Russell syndrome born after in vitro fertilization. 相似文献
94.
Kamio M Oki T Inomoto Y Tsuji T Yoshinaga M Douchi T 《The journal of obstetrics and gynaecology research》2007,33(1):87-90
We encountered a 10-year-old prepubertal girl with a normal ovary and oviduct torsion. Hemorrhagic infarction of the ovary and oviduct occurred, and these structures were laparoscopically removed. Torsion of the normal ovary and oviduct in a prepubertal girl is discussed. 相似文献
95.
Isolated adenomyotic cyst associated with severe dysmenorrhea 总被引:1,自引:0,他引:1
Kamio M Taguchi S Oki T Tsuji T Iwamoto I Yoshinaga M Douchi T 《The journal of obstetrics and gynaecology research》2007,33(3):388-391
A case of a 23-year-old, nulliparous female with a very rare isolated adenomyotic cyst inducing severe dysmenorrhea was seen. Transvaginal ultrasonographic tomography and magnetic resonance imaging (MRI) showed a 3 x 3-cm cystic mass within the left anterior wall of the uterine corpus. The cystic space was filled with hyperintense fluid on T1-weighted images, which was surrounded by hypointense tissue beside the right uterine corpus on T2-weighted images. The case was preliminarily diagnosed using MRI as having cavitated rudimentary uterine horn. However, hysterosalpingography excluded the possibility of uterine anomaly. A hemorrhagic adenomyotic cyst measuring 3 cm within the left anterior wall of the uterine corpus was surgically removed. There was no evidence of diffuse adenomyosis uteri. Dysmenorrhea completely disappeared postoperatively. 相似文献
96.
Sachiyo Onishi Masahiro Tajika Tsutomu Tanaka Keisaku Yamada Tomoyasu Kamiya Seiji Natsume Yasuhiro Shimizu Yasumasa Niwa 《Internal medicine (Tokyo, Japan)》2022,61(10):1531
Primary hepatocellular carcinoma (HCC) in patients <30 years old is extremely rare. In younger patients, HCC develops against a background of persistent hepatitis B virus infection. We herein report a 23-year-old woman with HCC with all-negative hepatitis virus markers developing in an apparently healthy liver. Imaging studies showed a 50-mm hypervascular mass in segment 4 of the left liver lobe, compatible with HCC. The patient underwent surgical resection. A histological examination showed the presence of poorly differentiated HCC. The patient was diagnosed with HCC developing in a healthy liver. This is an extremely rare case of non-B non-C HCC. 相似文献
97.
Kosuke Okuya Junki Mine Kaori Tokorozaki Isshu Kojima Mana Esaki Kohtaro Miyazawa Ryota Tsunekuni Saki Sakuma Asuka Kumagai Yoshihiro Takadate Yuto Kikutani Tsutomu Matsui Yuko Uchida Makoto Ozawa 《Emerging infectious diseases》2022,28(7):1451
Genetic analyses of highly pathogenic avian influenza H5 subtype viruses isolated from the Izumi Plain, Japan, revealed cocirculation of 2 genetic groups of clade 2.3.4.4b viruses among migratory waterfowl. Our findings demonstrate that both continuous surveillance and timely information sharing of avian influenza viruses are valuable for rapid risk assessment. 相似文献
98.
Neural substrates of evidence accumulation have been a central issue in decision-making studies because of the prominent success of the accumulation model in explaining a wide range of perceptual decision making. Since accumulation-shaped activities have been found in multiple brain regions, which are called accumulators, questions regarding functional relations among these accumulators are emerging. This study employed the deconvolution method of functional magnetic resonance imaging (fMRI) signals from human male and female participants during object-category decision tasks, taking advantage of the whole-brain coverage of fMRI with improved availability of temporal information of the deconvolved activity. We detected the accumulation activity in many non-category-selective regions (NCSRs) over the frontal, parietal, and temporal lobes as well as category-selective regions (CSRs) of the categorization task. Importantly, the frontal regions mostly showed activity peaks matching the decision timing (classified as “type-A accumulator”), while activity peaks of the parietal and temporal regions were behind the decision (classified as “type-B accumulator”). The CSRs showed activity peaks whose timing depended on both region and stimulus preference, plausibly reflecting the competition among the alternative choices (classified as “type-C accumulator”). The results suggest that these functionally heterogeneous accumulators form a system for evidence accumulation in which the type-A accumulator regions make decisions in a general manner while the type-B and type-C accumulator regions are employed depending on the modality and content of decision tasks. The concept of the accumulation system may provide a key to understanding the universality of the accumulation model over various kinds of decision tasks.SIGNIFICANCE STATEMENT Perceptual decision making, such as deciding to walk or stop on seeing the signal colors, has been explained theoretically by the accumulation model, in which sensory information is accumulated to reach a certain threshold for making decisions. Neural substrates of this model, however, are still under elucidation among candidate regions found over the brain. We show here that, taking advantage of the whole-brain coverage of functional magnetic resonance imaging (fMRI) with improving availability of temporal information by deconvolution method, the accumulation is conducted by a system comprising many regions in different abstraction levels and only a part of these regions in the frontal cortex make decisions. The system concept may provide a key to explaining the universality of the accumulation model. 相似文献
99.
Masakazu Toi MD Tsutomu Wada Hirofumi Yamada Akihiko Ohsaki Atsushi Yamamoto Takashi Nakamura Minoru Nimoto Takao Hattori 《Surgery today》1990,20(3):327-330
Growth fractions detected by a monoclonal antibody, Ki-67, were examined in 40 human breast cancer tissues and the results
compared with the immunocytochemical reactivities of epidermal growth factor receptor (EGFR) and estrogen receptor (ER). The
proportion of proliferating cells displaying Ki-67 positive staining was significantly higher in the EGFR positive tumors
than in the EGFR negative tumors (p<0.01). The average percentage of Ki-67 positive cells in the EGFR positive tumors was
19.9 per cent, whereas that in the EGFR negative tumors was 8.0 per cent. By contrast, an inverse relationship between the
proportion of proliferating cells and ER positive cells detected by anti-ER monoclonal antibody was observed. This data indicated
the difference in growth fractions with relation to the EGFR and ER status of breast cancer. 相似文献
100.
Management of pancreatic mass accompanying chronic pancreatitis 总被引:1,自引:0,他引:1
Yoshioka M Shibata S Sato T Furuya T Asanuma Y Hashimoto M Koyama K 《Journal of Hepato-Biliary-Pancreatic Surgery》2002,9(3):376-378
We report two patients with focal, chronic pancreatitis that was diagnosed by dynamic computed tomography (CT) combined with
intraoperative biopsy. In case 1, serum carbohydrate antigen (CA) 19-9 level rose to 160 U/ml. Abdominal ultrasonography,
CT, and magnetic resonance imaging demonstrated a mass, of 4.5 cm in diameter, in the pancreatic head. On dynamic CT, the
mass was enhanced similarly to the normal pancreatic parenchyma. In case 2, dynamic CT demonstrated a mass, of 3.0 cm in diameter,
in the pancreatic head, which was enhanced similarly to the normal pancreatic parenchyma. From such characteristics of enhancement,
both masses were suspected to be chronic pancreatitis rather than cancer, and the diagnosis was confirmed by intraoperative
biopsy. Three years in case 1 and 2 years in case 2 have passed since their operations, and the size of each mass has not
changed. With the use of dynamic CT combined with intraoperative biopsy, focal chronic pancreatitis could be diagnosed more
accurately, and this may lead to a reduction in unnecessary pancreatic resection.
Received: November 16, 2001 / Accepted: February 8, 2002 相似文献