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患者,女,57岁。躯干部白色丘疹3年。本例皮肤镜表现独特之处在偏振光浸润模式下与典型脂溢性角化病不同,由于色素减退,皮沟与皮嵴表现为浅褐色背景下放射状分布亮白色线状条纹,呈珊瑚样结构。 相似文献
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OBJECTIVES: To assess the effectiveness and safety of additional bedtime H2‐receptor antagonists (H2RAs) in suppressing nocturnal gastric acid breakthrough (NAB) via a systematic review. METHODS: Eligible trials were identified by searching the Cochrane Central Register of Controlled Trials (CENTRAL) (Cochrane Library Issue 2, 2004), MEDLINE (January 1966–June 2004), EMBASE (January 1980–June 2004) and CINAHL (January 1982–June 2004). Additional hand‐searching was conducted on the proceedings of correlated conferences, eight important Chinese journals and references of all included trials. All randomized controlled trials evaluating H2RAs for the control of NAB were eligible for inclusion. The systematic review was conducted using methods recommended by The Cochrane Collaboration. RESULTS: Only two randomized crossover studies, comprising 32 participants, met the inclusion criteria. Because the design, dosage and duration of the treatments were different between the studies, it was not possible to conduct meta‐analysis. There were no consistent conclusions found between the two included studies in evaluating H2RAs for the control of NAB. CONCLUSIONS: No implications for practice at this stage can be concluded. Appropriately designed large‐scale randomized controlled trials with long‐term follow up are needed to determine the effects of additional bedtime H2RAs in suppressing NAB. 相似文献
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Objective To investigate the relationship between degree of endometrioma adhesions and clinical feature, surgical treatment and postoperative recurrence. Methods From Jan 2003 to Mar 2008, 662 patients with endometrioma undergoing laparoscopic ovarian endometrioma excision in Peking Union Medical College Hospital were studied retrospectively. All patients were classified into four groups according to the extent of adhesions: 31 cases in none adhesions group, 123 cases in mild adhesions group (filmy thickness, avascular, easily separated adhesions), 310 cases in moderate adhesions group (less than a half of ovary was adjacent to dense thickness adhesions which was difficult to separate, or above a half of ovary were adjacent to filmy thickness adhesions) and 198 cases in severe adhesions group (above a half of ovary was adjacent to dense thickness, well vascularized adhesions which was difficult to separate, and always involved the other pelvic organs, observed angiogenesis). The comparison of degree, characteristics, period of pain, lab test, surgical management and postoperative recurrence was performed among those above groups. In the mean time, risk factors and multinomial logistic regression were analyzed. Results (1)Clinical characteristics: The incidence of patients with dysmenorrhea, dyspareunia, straining feeling in anus, chronic pelvic pain and the level of CA125 (>35 kU/L) was remarkably higher in moderate-to-severe adhesion groups than in none-to-mild adhesions groups (P=0.000, 0.000, 0.001, 0.006 and 0.000, respectively). Infertility rate were significantly higher in severe adhesions group(15.7%,31/198) than none adhesions group(3.2%,1/31), mild adhesions group(11.4%,14/123) and moderate adhesions group(9.7%,30/310, OR=1.728, P<0.05).(2)Operating time and blood loss: Operating time of each groups was as followed: (37±15) min in none adhesions group, (42±19) min in mild adhesions group, (50±20) min in moderate adhesions group and (63±22) min in severe adhesion group. Blood loss was (23±12) ml in none adhesion group, (31±27) ml in mild adhesion group, (40±32) ml in moderate adhesion group and (70±67) ml in severe adhesions group. Thicker adhesions result in longer operation time and more blood loss. (3)Combined with other disease: The ratio of patients who combined with adenomyosis or deeply infiltrating endometriosis in moderate-to-severer adhesion groups was higher than patients in none-to-mild adhesions groups (OR=3.466, P=0.000). (4) Postoperative recurrence: It was categorized into recurrence of pain and cyst. Moderate-to-severe adhesions was related to higher recurrence rate of pain (OR=1.685,P=0.046), but was irrelevant to recurrence of cyst. Conclusion The more extent of endometrioma adhesions was related to severer pelvic pain symptoms, longer operating time and more blood loss. Postoperative pain recurrence rate was observed in moderate-to-severe adhesion group. Extent of adhesions was irrelevant to cyst recurrence. 相似文献
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通过分析中国马拉松运动员ACE基因I/D多态频率分布特征,探讨其作为杰出耐力基因标记的可行性。选择我国马拉松健将、国际健将级运动员26名作为马拉松运动员组,汉族学生216名作为对照组。对两组受试者进行ACE基因I/D多态性测定。结果显示:我国马拉松运动员组的等位基因频率和基因型频率与对照组比较无显著差异,其中15名国际健将中无一DD型纯合子,提示我国优秀马拉松运动员的纯合子DD型频率低下是其ACE基因多态频率分布的主要特征。 相似文献
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目的 探讨多巴酚丁胺负荷情况下实验猪缺血心肌对18F-脱氧葡萄糖(FDG)的摄取情况.方法 15头中华小型猪,于冠状动脉左前降支近中段放置动脉环,造成慢性冠状动脉狭窄.分别在静息和多巴酚丁胺负荷试验时,进行99Tcm-甲氧基异丁基异腈(MIBI)心肌灌注和18F-FDG心肌代谢SPECT显像.99Tcm-MIBI心肌血流灌注图像用17段4分法进行半定量分析,通过测量心肌短轴感兴趣区(ROI)放射性计数,对缺损的可逆程度进行定量分析.18F-FDG心肌代谢图像分析通过在原始投影数据上勾画ROI,计算心脏与肝脏的平均放射性比值(H/Li)、心脏与右肺尖的平均放射性比值(H/L).所有实验猪均行冠状动脉造影检查.结果 冠状动脉造影发现,所有实验猪的冠状动脉左前降支狭窄均大于50%.99Tcm-MIBI药物负荷和静息显像时的心肌血流灌注半定量评分分别为(9.5±8.3)和(8.3±8.4)分,两者差异有显著性(P<0.05).缺损可逆程度比值为1.17±0.14.18F-FDG图像分析发现在静息情况下,H/Li比值为1.06±0.10,H/L比值为1.40±0.18;而在多巴酚丁胺负荷情况下,心脏对18F-FDG的摄取相对增加H/Li比值为1.25±0.15(P<0.0001),与缺血可逆程度呈明显正相关(r=0.64,P=0.007),H/L比值为1.77±0.33(P=0.001),与缺血可逆程度呈明显正相关(r=0.51,P<0.05).结论多巴酚丁胺负荷可使缺血心肌增加对18F-FDG的摄取. 相似文献
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陶瑞卿 《四川生殖卫生学院学报》2006,(5):13-16,23
生殖健康是当今国际社会关注的重要问题,也为我国政府重视。本文通过对攀枝花市人口与计划生育技术服务工作分析,总结出该市生殖健康服务模式的主要内容,对正确认识和提高我国西部地区人口生殖健康会水平,稳定我国低生育率水平,实现优生优育,具有十分重要的现实意义。 相似文献