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101.
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Simona Portaro Olimpia Musumeci Vincenzo Rizzo Carmelo Rodolico Mary G. Sweeney Maria Buccafusca Michael G. Hanna Antonio Toscano 《Neuromuscular disorders : NMD》2013,23(1):52-55
A 24-year-old woman complained of a 4-year history of muscle cramps, stiffness of the right lower limb and walking difficulties. After clinical and laboratory investigations, a diagnosis of multiple sclerosis was made. However, her family history revealed that her father and an older sister had lifelong symptoms of impaired muscle relaxation following contraction, improving with physical exercise. Molecular genetic studies in both sisters confirmed the diagnosis of myotonia congenita, due to a c.568GG>TC (Gly190Ser) pathogenic mutation in CLCN1 gene. Occurrence of two different neurological conditions in the same patient, both manifesting with stiffness, is quite unusual and suggests the opportunity of an accurate differential diagnosis. 相似文献
103.
Andrea E. Cavanna Chiara Luoni Claudia Selvini Rosanna Blangiardo Clare M. Eddy Paola R. Silvestri Paola V. Calì Emanuela Gagliardi Umberto Balottin Francesco Cardona Renata Rizzo Cristiano Termine 《Pediatric neurology》2013,48(2):111-114
Tourette syndrome is a neurodevelopmental disorder characterized by multiple tics and is often associated with comorbid behavioral problems. Research with generic instruments in child populations showed that comorbid disorders can have a greater impact on health-related quality of life than tic severity. This study investigated the usefulness of a newly developed disease-specific instrument, the Gilles de la Tourette Syndrome–Quality of Life Scale for Children and Adolescents (GTS-QOL-C&A), in assessing health-related quality of life in young patients with Tourette syndrome with and without behavioral comorbidity. We recruited 75 patients with Tourette syndrome (60 males; age 12.4 ± 3.2 years). All participants were evaluated by a neuropsychiatrist and completed a standardized psychometric battery, including the GTS-QOL-C&A, Child Depression Inventory, and Multidimensional Anxiety Scale for Children. Forty-two patients (56%) fulfilled diagnostic criteria for at least one comorbidity: obsessive-compulsive disorder (n = 25 patients [33.3%]); attention deficit/hyperactivity disorder (n = 6 patients [8%]); both (n = 11 patients [14.7%]). The GTS-QOL-C&A demonstrated usefulness in differentiating “pure” Tourette syndrome from Tourette syndrome “plus” behavioral problems with regard to health-related quality of life scores for the obsessive-compulsive subscale. In addition to focusing on core tic symptoms, the GTS-QOL-C&A showed sensitivity to the impact of behavioral comorbidities on health-related quality of life and can usefully complement existing nonspecific instruments. 相似文献
104.
Andrea Remuzzi Fabio Sangalli Daniela Macconi Susanna Tomasoni Irene Cattaneo Paola Rizzo Barbara Bonandrini Elena Bresciani Lorena Longaretti Elena Gagliardini Sara Conti Ariela Benigni Giuseppe Remuzzi 《Journal of the American Society of Nephrology : JASN》2016,27(3):699-705
Chronic renal insufficiency inexorably progresses in patients, such as it does after partial renal ablation in rats. However, the progression of renal diseases can be delayed by angiotensin II blockers that stabilize renal function or increase GFR, even in advanced phases of the disease. Regression of glomerulosclerosis can be induced by angiotensin II antagonism, but the effect of these treatments on the entire vascular tree is unclear. Here, using microcomputed tomography and scanning electron microscopy, we compared the size and extension of kidney blood vessels in untreated Wistar rats with those in untreated and angiotensin II antagonist–treated Munich Wistar Frömter (MWF) rats that spontaneously develop kidney disease with age. The kidney vasculature underwent progressive rarefaction in untreated MWF rats, substantially affecting intermediate and small vessels. Microarray analysis showed increased Tgf-β and endothelin-1 gene expression with age. Notably, 10-week inhibition of the renin-angiotensin system regenerated kidney vasculature and normalized Tgf-β and endothelin-1 gene expression in aged MWF rats. These changes were associated with reduced apoptosis, increased endothelial cell proliferation, and restoration of Nrf2 expression, suggesting mechanisms by which angiotensin II antagonism mediates regeneration of capillary segments. These results have important implications in the clinical setting of chronic renal insufficiency. 相似文献
105.
Occupational exposure to nitrous oxide during procedural pain control in children: a comparison of different inhalation techniques and scavenging systems 下载免费PDF全文
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BACKGROUND AND PURPOSE: Because musculoskeletal conditions contribute to functional decline and activity limitation, physical therapy intervention may be an appropriate health care resource. The purpose of this research was to identify determinants of outpatient physical therapy use by people with musculoskeletal conditions. SUBJECTS: The subjects were adult noninstitutionalized civilians who participated in the Medical Expenditure Panel Survey from 1996 to 2000 and who had at least one musculoskeletal condition (N=18,546). METHODS: Logistic regression was used to identify predisposing, need, and enabling variables associated with receiving outpatient physical therapy services. RESULTS: Factors that were positively associated with receiving physical therapy services were having more than one musculoskeletal condition, having some limitation in function, having 7 or more ICD-9 (International Classification of Diseases, 9th Revision) codes, having a college or advanced degree, and residing in an urban area. Factors that were negatively associated with receiving physical therapy services were being older than 65 years of age, having no high school degree, Hispanic ethnicity, African-American race, having public insurance or no insurance, and living in any US census region besides the Northeast. DISCUSSION AND CONCLUSION: The results of this study indicate that health- and non-health-related factors influence outpatient physical therapy use. 相似文献
108.
Piaggesi A Macchiarini S Rizzo L Palumbo F Tedeschi A Nobili LA Leporati E Scire V Teobaldi I Del Prato S 《Diabetes care》2007,30(3):586-590
109.
Giannoccaro Maria Pia Matteo Eleonora Bartiromo Fiorina Tonon Caterina Santorelli Filippo M. Liguori Rocco Rizzo Giovanni 《Neurological sciences》2022,43(9):5501-5511
Neurological Sciences - An increasing number of cases of comorbid hereditary spastic paraplegia (HSP) and multiple sclerosis (MS) have been described. We report a patient with the SPG3A form of HSP... 相似文献
110.
Daniele Borsetto Jonathan M. Fussey Diego Cazzador Joel Smith Andrea Ciorba Stefano Pelucchi Sara Don Paolo Boscolo‐Rizzo Michele Tomasoni Davide Lombardi Piero Nicolai Elisabetta Zanoletti Roberta Colangeli Enzo Emanuelli Max S. Osborne Syed F. Ahsan Margherita Tofanelli Giancarlo Tirelli Katherine McNamara Leonard Liew Katherine Harrison Ambrogio Fassina Samantha Sarcognato Neil Sharma Kanishka Rao Paul Pracy Paul Nankivell 《Head & neck》2020,42(3):522-529