The recent development of 2-dimensional strain (2D strain) imaging can provide a powerful alternative for assessing left ventricular
(LV) torsion. This study was conducted to evaluate the global and regional left ventricular twist by 2D strain in patients
with anterior wall myocardial infarction (AMI). A total of 55 AMI patients were divided into two groups according to their
ejection fraction (EF) values (group A: LVEF ⩾ 50%; group B: LVEF < 50%), and 35 normal people served as the control group.
Using 2-dimensional strain software, global and regional LV rotation and displacement were obtained at two planes. Compared
with the control group, patients of group A showed reduced peak LV twist of the anterior and anterior-septal wall (9.26±1.89
vs 10.74±2.67; 9.71±1.71 vs 11.36±2.29, both P < 0.05), but the radial displacement and global twist were maintained (P > 0.05). Differently, regional and global LV twist and radial displacement in patients of group B deceased significantly,
especially in the anterior and anterior-septal wall, as compared with patients in the control or group A (both P < 0.05). Moreover, a strong correlation was noted between peak twist and radial displacement; the twist-displacement loop
was markedly distorted in patients of group B. This study demonstrated that 2D strain has a potential ability for quantification
of left ventricular global and segment twist and radial displacement in patients with coronary artery disease. 相似文献
Background: Chronic pain models are commonly defined as either nerve-injury or inflammation models, but recent work suggests inflammatory processes are important in nerve injury-induced pain.
Methods: In the rat spinal nerve ligation model, the authors examined effects of systemic corticosteroid triamcinolone acetonide (TA) on the cytokine protein profile and sympathetic sprouting in the axotomized sensory ganglia, excitability of sensory neurons, and mechanical sensitivity.
Results: By postoperative day 3, marked increases (5- to 16-fold) in monocyte chemoattractant protein-1, growth-related oncogene (GRO/KC or CXCL1), and interleukin (IL)-6 were observed, whereas IL-4 and IL-2 levels fell more than fourfold. The increased cytokines and number of sympathetic basket formations in the sensory ganglia were reduced toward normal values by TA given starting at the time of injury. Interleukin-4 and IL-2 levels were not restored by TA. Systemic TA also reduced the firing rate and incidence of bursting activity, but not the overall incidence of spontaneous activity, in large- and medium-sized neurons. Mechanical hypersensitivity on postoperative day 3 was reduced by TA, and some effect could still be observed 4 days after cessation of TA. However, starting TA at day 7 was ineffective. 相似文献
