排序方式: 共有60条查询结果,搜索用时 15 毫秒
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目的 比较TAC(多西他赛+阿霉素+环磷酰胺)和FAC(氟尿嘧啶+阿霉素+环磷酰胺)方案后行乳腔镜保乳手术的疗效,为临床选择新辅助化疗方案提供指导.方法 回顾性分析用FAC和TAC新辅助化疗方案(各33例)后行乳腔镜保乳术治疗的乳腺癌患者的临床资料.结果 FAC方案组的总缓解率为54.5%,TAC组总缓解率为84.8%,两组患者总缓解率差异有统计学意义(P<0.05).TAC组的白细胞毒性和脱发的发生率高于FAC组,差异有统计学意义(P<0.05).两组术后并发症及美容效果差异均无统计学意义(均P> 0.05).结论 FAC及TAC新辅助化疗方案疗对局部晚期乳腺癌均有效,TAC方案优于FAC方案. 相似文献
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患者女性,71岁。因间歇性发作心悸,气短、胸闷10年,加重半月入院。体检:BP15/7.OKPa,心律不整,闻及“早搏”心尖区闻及Ⅲ级收缩期吹风样杂音,胸透见主动脉结处环状钙化阴影,心脏形态无异常。临床诊断:冠心病。心电图(附图下方的数字表示窦性P—P间距,Ⅲa 相似文献
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副肝动脉瘤破裂出血临床罕见,通过CT血管造影检查(CTA)或多层面重建可为临床诊断提供可靠依据,介入手术是其主要治疗手段。本研究采用介入栓塞成功治疗1例副肝动脉瘤破裂出血病例。该病人副肝动脉变异属于Michels 4型,通过CTA与数字减影血管造影检查明确变异血管出血部位,经介入栓塞治疗后随访,其治疗效果良好。 相似文献
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Objective To study the effects of indomethacin on proliferation and invasion of hepatocellular carcinoma (HCC) cell line MHCC97L with metastatic potential and the effect of indomethacin on the growth and metastasis of HCC. Methods (1) In vitro; Proliferation, Transwell invasion assay, cell motility assay, vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) protein activity were evaluated after cells were treated with 0. 2 mmol/L indomethacin. (2)In vivo: Mice bearing xenografts in the liver were randomly divided into control and indomethacin groups. At the end of sixth week, the mice were killed and tumor volume, inhibitory rate, immunohistochemistry assay (IHA) and metastasis were evaluated. Results (1)In vitro; 0. 2 mmol/L indomethacin could inhibit the proliferation of MHCC97L cells markedly (P <0. 01). The average amount of invading cells per field in cell invasion assay and motility assay was 2. 2 ± 1. 3 and 4.4 ± 1. 1 respectively in indomethacin group, significantly less than in control group ( 11. 4 ± 1. 9 and 12. 8 ± 1. 8 respectively, P <0. 01). The expression of VEGF and MMP-2 in cells treated with indomethacin was significantly lower than in control group (P <0. 01). (2)In vivo; Tumor volume, incidence and number of lung metastases in control and indomethacin groups were (1700 ±422) mm3 and (1170 ± 585) mm3 (P < 0. 05), 75% and 50% ( P > 0.05), 2. 92 ± 2. 07 and 1.33 ±1.56 (P<0. 05) , respectively. Inhibition rate in indomethacin group was 31.2%. IHA showed that the expression of VEGF, MMP-2, and cyclooxygenase-2 ( COX-2) was down-regulated in indomethacin group (P <0.01). Conclusion Indomethacin could inhibit the growth and metastasis of HCC, which was in part mediated by down-regulation of VEGF and MMP-2. 相似文献
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患者男性,36岁。因胸不适伴心悸3月来诊。既往无心动过速史。查体:血压128/90mmHg,心律整,未闻及杂音,除心电图异常外其他检查均未发现异常。查心电图(图1A)示:Ⅱa、Ⅱb系连续记录。Ⅱa、Ⅱb、V1导联前2次激动皆为窦性心搏,P—R间期0.14s,P—J间期0.24s,QRS波群时限0.07s,起始部未见“8”波,频率62次/分,Ⅱa导联第4,Ⅱb导联第3~8次心搏,V1导联第3~8次心搏皆系异位心搏,P波呈逆行性,P—R间期0.08s,QRS波群宽大畸形,时限0.14s,起始部粗钝,P—J间期0.22s,继发性ST—T改变, 相似文献
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目的:研究母亲DPP同源物4 (mothers against decapentaplegic homolog 4,Smad4)、母亲DPP同源物7(mothers against decapentaplegic homolog 7,Smad7)和小窝蛋白1 (Caveolin-1)在Wistar大鼠口腔黏膜癌变过程中的表达,了解TGF-β/Smad信号传导通路和小窝蛋白Caveolin-1在口腔癌前病变中的作用.方法:采用郑州大学口腔医学院存档的Wistar大鼠口腔腭部黏膜癌变标本,包括正常黏膜5例,单纯增生黏膜10例,轻度异常增生黏膜6例,中度异常增生黏膜7例,重度异常增生黏膜13例,口腔癌变组织28例.应用免疫组织化学SP法检测Smad4、Smad7和Caveolin-1蛋白的表达,采用SPSS 15.0软件包对数据进行统计学分析.结果:Smad4蛋白在正常和单纯增生黏膜、上皮异常增生黏膜和口腔癌黏膜中表达依次降低,3组间差异显著(P<0.05);Smad7和Caveolin-1蛋白在正常和单纯增生黏膜、上皮异常增生黏膜和口腔癌黏膜中表达均依次升高,3组间差异显著(P<0.05).经Spearman相关分析,Smad4与Smad7蛋白表达呈负相关,Smad4与Caveolin-1蛋白表达呈负相关,Smad7与Caveolin-1蛋白表达呈正相关(P<0.05).结论:Smad4、Smad7和Caveolin-1蛋白在口腔黏膜癌变过程中可能存在协同作用. 相似文献
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患者男性,37岁。临床诊断:心肌炎。查心电图(图1)示:Ⅱa~Ⅱc系连续记录。基本节律为窦性心律,P—P间距0.48~0.52s,P—R间期0.12s,QRS波群呈Rs型,时限为0.08s。另外可见两类宽大畸形的QRS波群。其一(E1)可见偶联间期不等(0.44—0.70s), 相似文献