对老年性痴呆患者子女进行心理干预的效果观察

目的探讨家庭照料的老年性痴呆患者子女心理健康状况及护理干预效果,更好地为社区心理卫生服务提供依据。方法采用90项症状自评量表(SCL-90)和一般情况问卷,对愿意接受心理健康测评和护理干预的185名家庭照料的老年性痴呆患者子女进行了心理危机干预研究。结果干预前185名老年性痴呆患者子女的SCL-90测评显示,10个因子中躯体化、强迫、人际敏感、抑郁、焦虑5项因子分高于常模(P<0.01)。通过心理危机干预后,此5项因子分均明显下降(P<0.05或P<0.01)。结论运用心理危机干预能在一定程度上改善老年性痴呆患者子女的负性认知和不良情绪,转变他们消极的应对方式。     

气管隆突部分切除重建术麻醉（附1例报告）

气管隆突部神经鞘瘤，临床上非常少见。我院于2004年2月21日，成功的为一例气管隆突部神经鞘瘤患者行气管隆突部分切除重建术，现将麻醉处理报告如下：     

金黄色葡萄球菌的耐热性能与奶制品引起的葡萄球菌食物中毒关系的研究

本文对66株金黄色葡萄球菌进行了耐热性观察,其结果80℃30分钟和90℃5分钟100％存活,100℃3分钟仍有43.9％存活,这和过去对该菌耐热性的认识有所不同。实验还表明,高温灭菌器可有效地杀灭葡萄球菌,是消毒牛奶的理想方法。本文为食品卫生管理和预防葡萄球菌食物中毒提供了科学依据。     

槐的临床应用

槐为豆科植物的槐树，又称豆槐、白槐、细叶槐、护房树等。为落叶乔木，生于山坡、平原或庭院内外种植，分布于我国大部分地区，其花、叶、枝、胶、根、白皮、角等均具有一定的药用价值，现介绍如下。     

小儿氯胺酮麻醉恢复期的呼吸道管理

目的 探讨小儿氯胺酮麻醉恢复期呼吸道的管理措施.方法 对笔者所在医院收治的200例小儿氯胺酮麻醉恢复期的呼吸管理进行回顾性分析.结果 200例小儿氯胺酮麻醉恢复期呼吸道管理措施得当,平安度过.结论 小儿氯胺酮麻醉恢复期正确的呼吸道管理可以使患儿平稳度过麻醉恢复期.     

PET/CT在评价及观察大鼠肺癌放疗效果中的应用

Objective The aim of this study was to understand the role of PET/CT in monitoring the therapeutic effect of radiotherapy (RT) on lung cancer with Wistar rats. Methods Thirty Wistar in-bred strain rats (6-8 weeks, weighed 180-280 g, female, ordinary) were made into Lewis pulmonary tumor model rats. 18F-fluorodeoxyglucose (FDG) PET/CT was performed when tumor reached 1.5-2.0 cm in greatest diameter (4-6 weeks) as a baseline. In order to get the optimal time point of PET/CT for moni-toring RT effect in rat cancer model, PET/CT was performed at the 3rd day, 1st, 2nd, 3rd, and 4th week after giving single dose of 5 Gy to each rat. Standardized uptake values (SUV) from FDG PET were measured and rats were sacrificed at different time point for validation. Besides, the expressions of glucose transport1 (Glut1) in tumor tissue were studied using immunohistochemistry. The level of tumor cell apoptosis, degra-dation, and necrosis were observed. SPSS 11.0 software was used for data analyses. Results A negative correlation of SUV uptake and time after RT and negative correlation of Glut1 expression and time after RT were observed in rat tumors, respectively. Positive correlation of SUV uptake and Glut1 expression in rat tumors was observed (Spearman rank correlation test, rs = 0.97, P < 0.01). Before RT, the SUV in rat tumor was 1.28 ± 0.31 and was decrease to 1. 00 ± 0.23 at the 3rd day and 0.18 ± 0. 10 at the 4th week after RT (F=15. 126, P<0.05). Before RT, the Glut1 in rat tumor was 0.2558 ±0.03 and was decrease to 0. 2320 ± 0. 01 at the 3rd day and 0. 1320±0.04 at the 4th week after RT. The amounts of tumor cell apopto-sis, degradation, and necrosis increased with time after RT. Conclusion Though FDG PET could monitor the therapeutic effect at the 3rd day after giving single dose of RT to rat lung tumor model, the optimal time was the the 4th week after treatment.     

卡维地洛的降压及肾脏保护作用观察

目的观察卡维地洛的降压疗效及其对尿微量白蛋白（Alb）和β2-微球蛋白（β2-MG）排泄的影响。方法采用自身对照法观察50例轻、中度高血压患者，所有患者停用降压药物2周，然后口服卡维地洛，开始3d为6，25mg／次，2次／d，以后改为12．50mg／次，2次／d，如2周后血压仍≥140／90mmHg，则剂量倍增到25，00mg／次，2次／d，至24周结束。测定治疗前、后24hAlb和β2-MG的排泄。结果24周后显效19例，有效24例，无效7例，有效率为86％。50例患者治疗前、后SBP、DBP、Alb和β2-MG间差异有非常显著性意义（P〈0.01）。结论卡维地洛是治疗轻、中度高血压的一种安全有效的降压药物，同时能减少Alb和β2-MG的排泄，对肾脏具有保护作用，且不影响血脂及糖代谢。     

药师角色一次有别传统的界定指导合理用药,参与新药临床研究

不久前,首届中国药师大会在北京举办,卫生部部长陈竺在大会所作发言中提出:中国的药师应为建立具有中国特色的药物创新体系做出更大贡献.陈竺特别强调了在中国建立临床研究基地及医疗机构中加强临床药师队伍建设的重要性,希望药师们不仅更好的指导临床合理用药,还应该在药物创新与临床药学中发挥更大的作用.