Ozone Levels in Central Israel

Measurements performed during the early summer months of 1988–1991 at a rural site in central Israel, some 50 km east of the highly urbanized coastal region, have shown that during the afternoon hours the area was often under the influence of ozone mixing ratios above the Israel ambient standard (117 ppbv) and occasionally even above 150 ppbv. Analysis of air mass back trajectories has shown that only those air masses passing over the Tel Aviv metropolitan area cause elevated ozone mixing ratios at the rural site. This highly urbanized region emits large amounts of precursors which are entrapped in the air parcels entering Israel under the predominantly westerly wind flows. As these air masses travel inland, sufficient time is available (3–5 h) to allow the photochemical reactions to generate ozone before reaching the rural site. The above hypothesis is further supported by the fact that parallel to the increase of ozone at the rural site, elevated carbon monoxide (up to 0.8 ppmv) and other trace gases were also observed. A significant correlation (R² > 0.8) was found to exist between the ozone mixing ratio and the NO_x concentrations in photochemically aged air masses. In several cases an excess of up to 12 ozone molecules was formed for each NO_x molecule present.     

Two-dimensional elastoplasticity: Approximation by mixed finite elements

Two-dimensional elastoplastic problems are used to assess the performance of a family of mixed finite elements in the non-linear regime. In particular, four-node bilinear quadrilateral elements that exhibit high accuracy in coarse meshes are used to simulate plane stress, plane strain, axisymmetric and (shear-deformable) plate bending problems. The excellent performance of these elements is demonstrated with a number of discriminating examples selected from the literature. In addition, agreement is observed in the limit load predicted by the axisymmetric solid and plate bending elements.     

Mass transfer and reaction kinetics in the ozone/tap water system

The mass transfer and the reaction kinetics of ozone in tap water were examined. The contacting system was a well-mixed reactor with perpendicular jets. The ozone residual range was the lowest detectable range. A simple mathematical model was proposed to describe the mechanism of the ozone in the reactor and was checked over the range of water flow rates from 2.170 to 3.080 l min⁻¹, gas flow rates from 0.667 to 1.333 l min⁻¹ and different temperature conditions. The proposed model describes quite accurately the mass-transfer behavior in the reactor and determines the operational parameters which control the reactor operation. There is a linear relationship between the ozone feed rate and ozone residual. Zero order kinetics best describe the autodecomposition of ozone in plain tap water. The mass transfer coefficient is about 1.14 min⁻¹. Without use of agitation, there is a large decrease in the value of the mass transfer coefficient, to about 0.250 min⁻¹. The magnitude of the reactor rate constant is between 0.05 and 0.13 mg min⁻¹ l.     

Self-stabilizing extensions for meassage-passing systems

Summary A self-stabilizing program eventually resumes normal behavior even if excution begins in, an abnormal initial state. In this paper, we explore the possibility of extending an arbitrary program into a self-stabilizing one. Our contributions are: (1) a formal definition of the concept of one program being aself-stabilizing extension of another; (2) a characterization of what properties may hold in such extensions; (3) a demonstration of the possibility of mechanically creating such extensions. The computtional model used is that of an asynchronous distributed message-passing system whose communication topology is an arbitrary graph. We contrast the difficulties of self-stabilization in thismodel with those of themore common shared-memory models. Shmuel Katz received his B.A. in Mathematics and Englisch Literature from U.C.L.A., and his M.Sc. and Ph.D. in Computer Science (1976) from the Weizmann Institute in Rechovot, Israel. From 1976 to 1981 he was a research at the IBM Israel Scientific Center. Presently, he is an Associate Professor in the Computer Science Department at the Technion in Haifa, Israel. In 1977–78 he visited for a year at the University of California, Berkeley, and in 1984–85 was at the University of Texas at Austin. He has been a consultant and vistor at the MCC Software Technology Program, and in 1988–89 was a visiting scientist at the IBM Watson Research Center. His research interests include the methodology of programming, specification methods, program verification and semantics, distributed programming, data structure, and programming languages. Kenneth J. Pery has performed research in the area of distributed computing since obtaining Masters and Doctorate degrees in Computer Science from Cornell Univesity. His current interest is in studying problems of a partical nature in a formal context. He was graduated from Princeton University in 1979 with a B.S.E. degree in Electrical Engineering and Computer Science.The Research of this author was partially supported by Research Grant 120-749 and the Argentinian Research Fund at the Technion     

Lymphoma and leukemia complicating pregnancy

The hematologic malignancies rarely complicate pregnancy. Pregnancy is not thought to affect the course of either Hodgkin's lymphoma, non-Hodgkin's lymphoma, or the leukemias. The prognosis worsens only if there is a delay in diagnosis or treatment. Both chemotherapy and radiotherapy have been administered during pregnancy with favorable results.     

Interactive software for estimating the efficacy of non-isothermal heat preservation processes

The most commonly used methods to generate microbial inactivation curves are based on the assumptions that microbial mortality follows first order kinetics and that the temperature effect on the 'D value' or exponential rate constant is determined by the log linear model or the Arrhenius equation, respectively. However, many bacterial cells and spores follow the Weibull-Log Logistic (WeLL) model and software to simulate pasteurization and sterilization processes using this model has been available for some years as free downloadable programs written in MS Excel. According to this model, an organism's heat resistance parameters are T(c), a marker of the temperature level where the inactivation accelerates, k, the steepness of the Weibullian rate parameter in the lethal regime where T>T(c) and n, a measure of the semi logarithmic isothermal survival curve's concavity and its direction. Because the traditional first order kinetics is just a special case of the Weibullian model with n=1.0, the software is applicable to both linear and non-linear inactivation. Recently, Wolfram Research Inc., the maker of Mathematica, has made its interactive program Mathematica Player free downloadable software. A user, who need not have a copy of Mathematica, can view and download any of the numerous graphic demonstrations from the Wolfram Demonstrations Project web site, and continuously manipulate their dynamic parameters with sliders on the screen. One set of five such demonstrations allows the user to generate and adjust the temperature profile of heat processes, modify the targeted organism's Weibullian survival parameters and immediately observe the corresponding semi-logarithmic survival curve and the equivalent time at a reference temperature, which can also be manipulated by a slider. This free program enables food microbiologists, technologists and engineers to examine a large number of heat processing options and assess their potential safety implications. It can also serve as a training and educational tool in industry and academia.     

FTIR Microscopic Studies on Normal, Polyp, and Malignant Human Colonic Tissues

Fourier-Transform Infrared Spectroscopy (FTIR) employs a unique approach tooptical diagnosis of tissue pathology based on the characteristic molecularvibrational spectra of the tissue. The biomolecular changes in the cellularand sub-cellular levels developing in abnormal tissue, including a majorityof cancer forms, manifest themselves in different optical signatures, whichcan be detected in infrared microspectroscopy. This report has two parts. Inthe first part, we report studies on normal, premalignant (polyp) andmalignant human colonic tissues from three patients with different stages ofmalignancy. Our method is based on microscopic infrared study (FTIR-microscopy)of thin tissue specimens and a direct comparison with traditional histopathologicalanalysis, which serves as a gold reference. The limited dataavailable showed normal colonic tissue has a stronger absorption thanpolypoid tumor and cancerous types over a wide region in a total of 100measurements. Detailed analysis showed that there is a significant decreasein total carbohydrate, phosphate and possibly creatine contents for polyp andcancerous tissue types in comparison to the controls. The same trend is maintainedin seven other patients studied. The second part consists of an analysis showingthe influence of various independent factors such as age, sex and grade of malignancy. Ourpreliminary results suggest that among the above three factors, age and gradeof malignancy have significant effect on the metabolites level, but sex has onlyminor effect on the measured spectra. Initial results on Linear DiscriminantAnalysis (LDA) showed good classification between normal and malignant cellsof human colonic tissues.     

SDS-PAGE under focusing conditions: an electrokinetic transport phenomenon based on charge compensation

A novel method is reported for mass separation of proteins, based on sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Unlike conventional SDS-PAGE, in which separation by mass of SDS-laden polypeptide chains is obtained in constant concentration or porosity gradient gels, the present method, called "SDS-PAGE focusing", exploits a "steady-state" process by which the SDS-protein micelles are driven to stationary zones along the migration path against a gradient of positive charges affixed to the neutral polyacrylamide matrix. As the total negative surface charge of such complexes matches the surrounding charge density of the matrix, the SDS-protein complex stops migrating and remains stationary, as typical of steady-state separation techniques. As a result of this mechanism, the proteins are separated in an unorthodox way, with the smaller proteins/peptides staying closer to the application point and larger proteins migrating further down toward the anodic gel end. This results in a positive slope of the Mr vs migration plot, vs a negative slope in conventional SDS-PAGE. Moreover, such a plot is linear (by design), whereas in standard SDS-PAGE it is semi- or even double logarithmic. Particularly advantageous appears the ability of the present method to fine-tune the separation of small-size fragments and tryptic digests, where conventional SDS-PAGE usually fails. Additionally, by exploiting constant plateaus of charges, rather than gradients, it is possible to amplify the separation between species having closely spaced Mr values, down to a limit of approximately 150 Da. This increases the resolution by at least 1 order of magnitude as compared with standard SDS-PAGE, where for a proper separation of two adjacent species, an Mr increment of approximately 3000 Da is needed.     

Simulation of Fluctuating Populations of Microorganisms and Macroorganisms with Models Having a Normal Random Variate Term

Fluctuating populations of micro- and macroorganisms play a major role in the stability and safety of food and agricultural products. In recent years such populations have been described by ‘chaotic’ models, most notably the discrete logistic function. This model's major limitations, however, are that it implies determinism and that it can account for neither population explosions nor extinction. Consequently, it is suggested that in order to simulate realistic population histories, the growth rate constant, r, in the original discrete logistic function X_n+1=rX_n(1-X_n) can be replaced by a randomly varying term, r_n. The latter can be defined as r_n=r₀ exp(kZ_rn) where r₀ is a characteristic constant, Z_rn a normal random variate produced by a normally distributed random number generator and k its chosen standard deviation. Theoretically, the magnitude of such r_n (and its corresponding X_n) can be anywhere in the range 0<X_n<∞. However, the magnitude of k can be selected so that X_n>1 is a very rare event. In the special case of widely fluctuating populations dominated by random factors, the model can be replaced by N_n/N₀=exp(k′Z_rn), where N₀ is a characteristic number. In this form the model can account for occasional aperiodic population explosions, and if a lower limit to a viable number is also set (eg N/N₀>0·01), for extinction events as well. The flexibility of the two models is demonstrated with simulated population evolution patterns of different kinds. © 1997 SCI.