Breast milk from healthy women has higher anti-Candida properties than women with vaginal infections during pregnancy

Food Science and Biotechnology - The aim of this study was to investigate the different immunological and antimicrobial properties of breast milk from women with (W) or without (WO) vaginal yeast...     

Green Synthesis-Mediated Silver Nanoparticles Based Biocomposite Films for Wound Healing Application

Journal of Inorganic and Organometallic Polymers and Materials - Wound care is a clinical challenge due to the susceptibility of the wound to multidrug-resistant bacterial infections. We report a...     

A Chimeric Peptide Inhibits Red Blood Cell Invasion by Plasmodium falciparum with Hundredfold Increased Efficacy**

Inhibiting the formation of a tight junction between two malaria parasite proteins, apical membrane antigen 1 and rhoptry neck protein 2, crucial for red blood cell invasion, prevents progression of the disease. In this work, we have used a unique approach to design a chimeric peptide, prepared by fusion of the best features of two peptide inhibitors, that has displayed parasite growth inhibition ex vivo with nanomolar IC₅₀, which is 100 times better than any of its parent peptides. Furthermore, to gain structural insights, we computationally modelled the hybrid peptide on its receptor.     

RESERVOIR CHARACTERIZATION OF THE PLIOCENE RED SERIES,LAM FIELD AND SURROUNDING AREAS,OFFSHORE WESTERN TURKMENISTAN

The sedimentology, petrography and reservoir potential of Pliocene sandstones within the Upper Red Series in the offshore LAM field, Western Turkmenistan, have been examined. Depositional settings are interpreted within the framework of the Red Series palaeoenvironments across the entire Turkmen sector of the Apsheron-Prebalkhan uplift zone, including its onshore extension to the east. Examination of 81 m of core from three separate intervals suggests that the Red Series in the LAM field is the product of a fluvial-dominated delta system with associated floodplain deposits, periodically flooded by the saline waters of the South Caspian Lake. Relatively thick sandstones, up to around 5 m thick, are interpreted as channel and point-bar deposits of a meandering river system, with thinner and finer-grained sandstones and siltstones inferred to be crevasse-splay and interdistributary floodplain deposits. Floodplain mudstones display signs of desiccation, soil formation, plant rootlets and occasional thin layers of anhydrite. Intervals with marine trace-fossil assemblages record incursions of saline-lake waters. Conglomeratic layers at the base of thicker mudstone intervals may be associated with abrupt transgressions of the lake. The best reservoir qualities are associated with the fluvial channel and point-bar sandstones. Crevasse-splay and other overbank sandstones are of poorer quality, while intercalated floodplain to lacustrine claystone/siltstone units may constitute local seals. Eighteen sandstone plug samples from the cored intervals were examined in thin-section and by XRD and SEM to assess how mineralogy, grain size and diagenesis affect reservoir quality. The samples consist predominantly of lithic arkoses and feldspathic litharenites; higher porosities, and therefore better reservoir potential, are associated with the feldspathic litharenites. Primary controls on porosity include compaction, clay-matrix content and calcite cementation. XRD data reveal the presence of illite, illite-smectite and chlorite. The presence of swelling clays has been the main cause of formation damage in the field. The interpretation of meandering fluvial channels here is thought to represent the first published account of such channels within Pliocene reservoir rocks in the north of the South Caspian Basin. Previous accounts of the Red Series sandstones deposited onshore to the east have indicated deposition within braided channels of the palaeo-Amu Darya river delta plain, and alluvial-fan deposits sourced from uplands to the north. Deposition of the equivalent Productive Series by the palaeo-Volga in the Azerbaijan sector to the west has also been interpreted as having taken place within braided systems, although mixed or suspended-load fluvial channels ascribed to the contemporary Kura delta farther south may have been associated with a meandering system. Two palaeogeographic maps are presented to illustrate depositional environments for the Red Series during relative high- and low-stands of the South Caspian Lake. The maps cover the area where the Productive Series of Azerbaijan passes into the Red Series of Western Turkmenistan.