Despeckle filtering software toolbox for ultrasound imaging of the common carotid artery

Ultrasound imaging of the common carotid artery (CCA) is a non-invasive tool used in medicine to assess the severity of atherosclerosis and monitor its progression through time. It is also used in border detection and texture characterization of the atherosclerotic carotid plaque in the CCA, the identification and measurement of the intima-media thickness (IMT) and the lumen diameter that all are very important in the assessment of cardiovascular disease (CVD). Visual perception, however, is hindered by speckle, a multiplicative noise, that degrades the quality of ultrasound B-mode imaging. Noise reduction is therefore essential for improving the visual observation quality or as a pre-processing step for further automated analysis, such as image segmentation of the IMT and the atherosclerotic carotid plaque in ultrasound images. In order to facilitate this preprocessing step, we have developed in MATLAB^® a unified toolbox that integrates image despeckle filtering (IDF), texture analysis and image quality evaluation techniques to automate the pre-processing and complement the disease evaluation in ultrasound CCA images. The proposed software, is based on a graphical user interface (GUI) and incorporates image normalization, 10 different despeckle filtering techniques (DsFlsmv, DsFwiener, DsFlsminsc, DsFkuwahara, DsFgf, DsFmedian, DsFhmedian, DsFad, DsFnldif, DsFsrad), image intensity normalization, 65 texture features, 15 quantitative image quality metrics and objective image quality evaluation. The software is publicly available in an executable form, which can be downloaded from http://www.cs.ucy.ac.cy/medinfo/. It was validated on 100 ultrasound images of the CCA, by comparing its results with quantitative visual analysis performed by a medical expert. It was observed that the despeckle filters DsFlsmv, and DsFhmedian improved image quality perception (based on the expert's assessment and the image texture and quality metrics). It is anticipated that the system could help the physician in the assessment of cardiovascular image analysis.     

Identifying the mechanism of protein loop closure: a molecular dynamics simulation of the Bacillus stearothermophilus LDH loopin solution

The ‘loop’ involving residues 98–110 in Bacillusstearothermophilus lactate dehydrogenase (BSLDH) is of greatinterest as substrate-induced ‘loop’ closure isthought to berate-limiting and essential in catalyzing the reactionand in determining substrate specificity. Consequently, we haveexplored the mechanism underlying ‘loop’ openingin BSLDH through a molecular dynamics simulation at high temperature(1000 K) in the presence of explicit solvent, starting fromthe X-ray structure of BSLDH complexed with the co-enzyme NAD+and oxamate at 2.5 Å. During the simulation, a significantconformational change occurred, as evidenced by sharp dihedralangle transitions, hydrogen bond breaking and formation andlarge root mean square deviations from the starting structure;these changes define the criteria for ‘loop’ opening.The mechanical elements responsible for ‘loop’ opening,i.e. ‘loop’ hinges and flap, are defined througha combination of order parameters, dihedral angle changes andtheir correlations and the dynamical cross-correlation map ofatomic displacements for the ‘loop’ residues. Theresults indicate that the ‘loop’ consists of twoflexible hinge regions on either side of a relatively rigidthree-residue segment that undergoes a significant spatial displacementduring ‘loop’opening. ‘Loop’ openingis made possible through an array of correlated dihedral anglechanges and intra-& ‘loop’ rearrangements ofhydrogen-bond interactions. The presentfindings are comparedto previous work related to ‘loop’ opening and site-directedmutagenesis experiments.     

Distributed fault diagnosis for continuous-time nonlinear systems: The input–output case

In this paper, some new results on distributed fault diagnosis of continuous-time nonlinear systems with partial state measurements are proposed. By exploiting an overlapping decomposition framework, the dynamics of a nonlinear uncertain large-scale dynamical system is described as the interconnections of several subsystems. Each subsystem is monitored by a Local Fault Diagnoser: a set of local estimators, based on the nominal local dynamic model and on an adaptive approximation of the interconnection and of the fault function, allows to derive a local fault decision. A consensus-based protocol is used in order to improve the detectability and the isolability of faults affecting variables shared among different subsystems because of the overlapping decomposition. A sufficient condition ensuring the convergence of the estimation errors is derived. Finally, possibly non-conservative time-varying threshold functions guaranteeing no false-positive alarms and theoretical results dealing with detectability and isolability sufficient conditions are presented.     

Using online consumer reviews as a source for demographic recommendations: A case study using online travel reviews

Online consumer reviews play an important role in the decision to purchase services online, mainly due to the rich information source they provide to consumers in terms of evaluating “experience”-type products and services that can be booked using the Internet, with online travel services being a significant example. However, different types of travelers assess each quality indicator differently, depending on the type of travel they engage in, and not necessarily their cultural or age background (e.g. solo travelers, young couples with children etc.). In this study, we present architecture for a demographic recommendation system, based on a user-defined hierarchy of service quality indicator importance, and classification of traveler types. We use an algebraic approach to ascertain preferences from a large dataset that we obtained from the popular travel website Booking.com using a web crawler and compared with the customer-constructed preference matrix. Interestingly, the architecture of the evaluated recommendation system takes into account already defined demand characteristics of the hotels (such as the number of reviews of specific consumer types compared to the total number of reviews) in order to provide an example architecture for a recommendation system based on user-defined preference criteria.     

Developing Knowledge-Based Intelligent Multimedia Tutoring Systems Using Semantic Content-Based Modelling

The complex nature of semantic video and audio content has made multimedia difficult to use within the traditional architecture of a knowledge-based intelligent tutoring system (ITS). This paper investigates how multimedia syntax and semantics may be integrated into the confines of the knowledge-based ITS architecture so as to develop a knowledge-based intelligent multimedia tutoring system (IMTS). The paper contributes a semantic content-based model that can be used for this purpose. Multimedia frames (m-frames) are used as the framework by which the syntactic and semantic information is represented within the model. The paper discusses how IMTSs may be developed using the model, and then demonstrates the use of our approach in the development of ARISTOTLE, an IMTS for teaching young children basic zoology.     

Electronic word-of-mouth and online reviews in tourism services: the use of twitter by tourists

Lately, the online social media have revolutionized communications and consequently the marketing of tourism destinations and businesses. The area is rapidly evolving and the challenges and opportunities arising from it for tourism industry are already apparent. Electronic word-of-mouth (e-WOM) and online reviews/recommendations are increasingly used regarding tourism services that are high involvement services. The purpose of the present study is to develop a conceptual framework for understanding the foundations of digital communication and empirically investigate its validity by examining the factors influencing the tourism consumer behavior. This study adopts a conceptual model of e-WOM and explores the use of Twitter by the tourists. Findings revealed the factors affecting tourists’ decision-making and indicated that this social medium is not a panacea; it is another marketing channel to be wisely used in integrated communications marketing of tourism services.     

Design and implementation of a MAC controller for the IEEE802.11 wireless LAN

IEEE 802.11 wireless LANs have a tremendous market potential, as they support high data rates, work in the world-wide licence free 2.4 GHz ISM band and have high performance in terms of range and power consumption. Hence, the development of a communication processor that supports the IEEE 802.11 MAC functions has a significant potential, making very important the concept of having an ASIC ‘right from the first time’, in order to minimize development cost and to meet short time-to-market requirements. This paper presents the methodology of developing such a component with emphasis on the rapid prototyping approach. The chip architecture, which is based on an ARM processor core, is described in detail, focusing on the implementation of the protocol functions using custom hardware modules. Finally, the paper presents experimental results on the ASIC implementation.     

Synergistic effects of buffer layer processing additives for enhanced hole carrier selectivity in inverted Organic Photovoltaics

Solution based inverted Organic Photovoltaic (OPVs) usually use Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) derivatives combined with pristine processing additives as hole selective contact on top of the hydrophobic conjugated polymer:fullerene active layer. In this study, PEDOT:PSS based hole selective contact is treated with two different boiling point additives, 2,5,8,11-tetramethyl-6-dodecyn-5,8-diol ethoxylate (Dynol) and Zonyl FS-300 fluorosurfactant (Zonyl). Although corresponding inverted OPVs using the above PEDOT:PSS:Additives show similar power conversion efficiency (PCE) values, the mechanisms of their implementation on inverted OPV operation are not identical. By understanding the synergistic effects of PEDOT:PSS processing additives on the hole selectivity of inverted OPVs we demonstrate a novel combination of PEDOT:PSS additives mixture as an effective route to further increase the hole selectivity, reliability andpower conversion efficiency of inverted OPVs.