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61.
Carlos Laorden Igor Santos Borja Sanz Gonzalo Alvarez Pablo G. Bringas 《Electronic Commerce Research and Applications》2012,11(3):290-298
Spam has become a major issue in computer security because it is a channel for threats such as computer viruses, worms, and phishing. More than 86% of received e-mails are spam. Historical approaches to combating these messages, including simple techniques such as sender blacklisting or the use of e-mail signatures, are no longer completely reliable. Many current solutions feature machine-learning algorithms trained using statistical representations of the terms that most commonly appear in such e-mails. However, these methods are merely syntactic and are unable to account for the underlying semantics of terms within messages. In this paper, we explore the use of semantics in spam filtering by introducing a pre-processing step of Word Sense Disambiguation (WSD). Based upon this disambiguated representation, we apply several well-known machine-learning models and show that the proposed method can detect the internal semantics of spam messages. 相似文献
62.
The influence of different centralised pre-packaging systems (PVC, modified atmosphere packaging (MAP), 25% CO(2) and 75% O(2), vacuum skin packaging (VSP) and the mother bag concept, 100% CO(2)) on the shelf-life (0, 7, 14 and 21 days at 0°C) of fresh pork was determined using microbiological, colour, odour and acceptability characteristics. All the packaging treatments were equally efficient for the first 4 days of retail display. In the extended shelf-life study (7, 14 and 21 days) the mother bag centralised packaging system gave the most promising shelf-life results (21 days) and was also judged superior in terms of odour. Modified atmosphere packaging (14 days) and VSP (7 days) may be considered as other possible options. 相似文献
63.
This study attempted to identify the major sources of work-related stress among telephone operators, with special emphasis on computer monitoring and telephone surveillance. A cross-sectional random sample of over 700 telephone operators participated in a questionnaire survey (response rate = 88%). The survey included items designed to measure perceived stress, management practices, specific job stressors and monitoring preferences. Call-time pressure items were most strongly linked to job stress by operators, with 70% reporting that difficulty in serving a customer well and still keeping call-time down contributed to their feelings of stress to a large or very large extent. About 55% of operators reported that telephone monitoring contributed to their feelings of job stress. If given the opportunity, 44% of operators stated they would prefer not to be monitored by telephone at all, while 23% stated they would prefer some monitoring; 33% had no preference. The setting of inappropriate individual-call-time objectives, which may be consistently unachievable for some operators and which create conflict between management demands for quantity and quality and also between workers values concerning quality and productivity demands, appears to be the most stress-inducing aspect of the job. In terms of telephone surveillance, the issues of timeliness and specificity of feedback appear to be less important than call-time pressure. 相似文献
64.
In finite labelled transition systems the problems of deciding strong bisimilarity, observation equivalence and observation congruence areP-complete under many—oneNC-reducibility. As a consequence, algorithms for automated analysis of finite state systems based on bisimulation seem to be inherently sequential in the following sense: the design of anNC algorithm to solve any of these problems will require an algorithmic breakthrough, which is exceedingly hard to achieve. 相似文献
65.
66.
In response to K. Danzinger's (see record 1986-00068-001) suggestion that the first use of the term subject in the English-language psychological literature occurred in 1886 in the context of experiments involving the hypnotic state, the present author points out that there are examples of the use of the term in discussions of experiments on thought transference published by the Society for Psychical Research in the 1880's. (8 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
67.
López-Castejón Maria Luisa Hurtado Maria del Carmen de la Fuente Julia Mena Baltasar Bengoechea Carlos 《Iranian Polymer Journal》2021,30(7):723-735
Iranian Polymer Journal - The present work focuses on the assessment of the ability of porcine plasma protein (PPP) to be electrospun satisfactorily to form fibre mats, and their rheological and... 相似文献
68.
Sofia Cotton Dylan Ferreira Janine Soares Andreia Peixoto Marta Relvas-Santos Rita Azevedo Paulina Piairo Lorena Diguez Carlos Palmeira Luís Lima Andr M. N. Silva Lúcio Lara Santos Jos Alexandre Ferreira 《International journal of molecular sciences》2021,22(4)
Esophageal cancer (EC) is a life-threatening disease, demanding the discovery of new biomarkers and molecular targets for precision oncology. Aberrantly glycosylated proteins hold tremendous potential towards this objective. In the current study, a series of esophageal squamous cell carcinomas (ESCC) and EC-derived circulating tumor cells (CTCs) were screened by immunoassays for the sialyl-Tn (STn) antigen, a glycan rarely expressed in healthy tissues and widely observed in aggressive gastrointestinal cancers. An ESCC cell model was glycoengineered to express STn and characterized in relation to cell proliferation and invasion in vitro. STn was found to be widely present in ESCC (70% of tumors) and in CTCs in 20% of patients, being associated with general recurrence and reduced survival. Furthermore, STn expression in ESCC cells increased invasion in vitro, while reducing cancer cells proliferation. In parallel, an ESCC mass spectrometry-based proteomics dataset, obtained from the PRIDE database, was comprehensively interrogated for abnormally glycosylated proteins. Data integration with the Target Score, an algorithm developed in-house, pinpointed the glucose transporter type 1 (GLUT1) as a biomarker of poor prognosis. GLUT1-STn glycoproteoforms were latter identified in tumor tissues in patients facing worst prognosis. Furthermore, healthy human tissues analysis suggested that STn glycosylation provided cancer specificity to GLUT1. In conclusion, STn is a biomarker of worst prognosis in EC and GLUT1-STn glycoforms may be used to increase its specificity on the stratification and targeting of aggressive ESCC forms. 相似文献
69.
Ignacio Hernandez Laura Tesoro Rafael Ramirez-Carracedo Javier Diez-Mata Sandra Sanchez Marta Saura Jose Luis Zamorano Carlos Zaragoza Laura Botana 《International journal of molecular sciences》2021,22(6)
In response to cardiac ischemia/reperfusion, proteolysis mediated by extracellular matrix metalloproteinase inducer (EMMPRIN) and its secreted ligand cyclophilin-A (CyPA) significantly contributes to cardiac injury and necrosis. Here, we aimed to investigate if, in addition to the effect on the funny current (I(f)), Ivabradine may also play a role against cardiac necrosis by reducing EMMPRIN/CyPA-mediated cardiac inflammation. In a porcine model of cardiac ischemia/reperfusion (IR), we found that administration of 0.3 mg/kg Ivabradine significantly improved cardiac function and reduced cardiac necrosis by day 7 after IR, detecting a significant increase in cardiac CyPA in the necrotic compared to the risk areas, which was inversely correlated with the levels of circulating CyPA detected in plasma samples from the same subjects. In testing whether Ivabradine may regulate the levels of CyPA, no changes in tissue CyPA were found in healthy pigs treated with 0.3 mg/kg Ivabradine, but interestingly, when analyzing the complex EMMPRIN/CyPA, rather high glycosylated EMMPRIN, which is required for EMMPRIN-mediated matrix metalloproteinase (MMP) activation and increased CyPA bonding to low-glycosylated forms of EMMPRIN were detected by day 7 after IR in pigs treated with Ivabradine. To study the mechanism by which Ivabradine may prevent secretion of CyPA, we first found that Ivabradine was time-dependent in inhibiting co-localization of CyPA with the granule exocytosis marker vesicle-associated membrane protein 1 (VAMP1). However, Ivabradine had no effect on mRNA expression nor in the proteasome and lysosome degradation of CyPA. In conclusion, our results point toward CyPA, its ligand EMMPRIN, and the complex CyPA/EMMPRIN as important targets of Ivabradine in cardiac protection against IR. 相似文献
70.
María Jos García Carlos Lucena Francisco Javier Romera 《International journal of molecular sciences》2021,22(9)
Iron (Fe) and phosphorus (P) are two essential elements for plant growth. Both elements are abundant in soils but with poor availability for plants, which favor their acquisition by developing morphological and physiological responses in their roots. Although the regulation of the genes related to these responses is not totally known, ethylene (ET) and nitric oxide (NO) have been involved in the activation of both Fe-related and P-related genes. The common involvement of ET and NO suggests that they must act in conjunction with other specific signals, more closely related to each deficiency. Among the specific signals involved in the regulation of Fe- or P-related genes have been proposed Fe-peptides (or Fe ion itself) and microRNAs, like miR399 (P), moving through the phloem. These Fe- or P-related phloem signals could interact with ET/NO and confer specificity to the responses to each deficiency, avoiding the induction of the specific responses when ET/NO increase due to other nutrient deficiencies or stresses. Besides the specificity conferred by these signals, ET itself could confer specificity to the responses to Fe- or P-deficiency by acting through different signaling pathways in each case. Given the above considerations, there are preliminary results suggesting that ET could regulate different nutrient responses by acting both in conjunction with other signals and through different signaling pathways. Because of the close relationship among these two elements, a better knowledge of the physiological and molecular basis of their interaction is necessary to improve their nutrition and to avoid the problems associated with their misuse. As examples of this interaction, it is known that Fe chlorosis can be induced, under certain circumstances, by a P over- fertilization. On the other hand, Fe oxides can have a role in the immobilization of P in soils. Qualitative and quantitative assessment of the dynamic of known Fe- and P-related genes expression, selected ad hoc and involved in each of these deficiencies, would allow us to get a profound knowledge of the processes that regulate the responses to both deficiencies. The better knowledge of the regulation by ET of the responses to these deficiencies is necessary to properly understand the interactions between Fe and P. This will allow the obtention of more efficient varieties in the absorption of P and Fe, and the use of more rational management techniques for P and Fe fertilization. This will contribute to minimize the environmental impacts caused by the use of P and Fe fertilizers (Fe chelates) in agriculture and to adjust the costs for farmers, due to the high prices and/or scarcity of Fe and P fertilizers. This review aims to summarize the latest advances in the knowledge about Fe and P deficiency responses, analyzing the similarities and differences among them and considering the interactions among their main regulators, including some hormones (ethylene) and signaling substances (NO and GSNO) as well as other P- and Fe-related signals. 相似文献