Locking and hourglass phenomena in an element‐free Galerkin context: the B‐bar method with stabilization and an enhanced strain method

The meshless methods, namely the element‐free Galerkin method (EFGM), when they first appeared claimed that volumetric locking and hourglass were avoided. This was not the case and both phenomena occur in the EFGM. In the context of the finite element method (FEM) these phenomena were widely studied. In this work, forms of avoiding the locking phenomenon will be presented; a formulation based on the enhanced strain method will be introduced in the EFGM and the B‐bar method will be implemented under the scope of the EFGM. Secondly, to render this method more robust, a stabilization technique will be implemented avoiding hourglass. Several examples are solved to probe the efficiency of these techniques. Copyright © 2006 John Wiley & Sons, Ltd.     

Considering Prework on Industrial Projects

Prefabrication, preassembly, modularization, and off-site fabrication, collectively termed as prework have become more viable with recent advances in design and information technologies. These construction methods offer a substantial opportunity to improve project performance when circumstances merit. Successful implementation of these methods on a particular project requires systematic analysis and early decision making based on specific factors of the project. This paper identifies those factors influencing decisions on the use of prework, and current industry practices for evaluating the applicability of prework on industrial projects. It then presents a decision framework to assist industry practitioners with evaluating the applicability of prework on their project, and describes a computerized tool to aid project teams in the decision-making process. The developed framework and tool are useful and effective in the decision-making process, and easy to use, as validated by practitioners in the industry.     

论计算运动学在机构理论中的作用

简述了计算运动学的发展过程，论述了计算运动学的基础理论，并利用两个实例展现了计算运动学在机构运动分析中的作用。最后以转向机构综合为例，对比传统综合方法和现代计算运动学方法的特点。结果表明：计算运动学方法在寻找所有解，精度和系统性等方面具有较大的优势。     

Multi-Level Composition for Software Federations

Reusability is the holly grail of software engineers. But reusability requires powerful composition mechanisms since the pieces to compose have no reason to match perfectly. Unfortunately, the composition mechanisms available today, mostly method call and component assembly are rather primitive. This paper shows what is the current state of the art in software composition, showing that there is little composition flexibility at code level, even using workflow approaches.The approach presented here claims that composition requires reasoning at different levels of abstraction. Workflow support is first decoupled from real tools, using abstract tool modeling. Contracts have been included to increase the independence between process and tools. Then, we have introduced conceptual abstractions linked by contract to real tools. Finally, we show that it is possible to define composition at the abstract level.The resulting system shows very high adaptability capabilities. Experience shows, however, that to be practical, this approach requires adapted framework and specialized tools. This paper shows the experience gained in implementing many versions of such a framework. The current system is currently in industrial use.     

Learning switching dynamic models for objects tracking

Many recent tracking algorithms rely on model learning methods. A promising approach consists of modeling the object motion with switching autoregressive models. This article is involved with parametric switching dynamical models governed by an hidden Markov Chain. The maximum likelihood estimation of the parameters of those models is described. The formulas of the EM algorithm are detailed. Moreover, the problem of choosing a good and parsimonious model with BIC criterion is considered. Emphasis is put on choosing a reasonable number of hidden states. Numerical experiments on both simulated and real data sets highlight the ability of this approach to describe properly object motions with sudden changes. The two applications on real data concern object and heart tracking.     

Development of an Active Thermoplastic Film with Oxygen Scavengers Made of Activated Carbon and Sodium Erythorbate

An active thermoplastic film made of low‐density polyethylene (LDPE) filled with oxygen scavengers made of powdered activated carbon (PAC) impregnated with sodium erythorbate (SE) was developed for packaging applications. Initial tests indicated that the impregnation of PAC with SE enhanced the heat resistance of SE, thereby allowing processing at temperatures typical of LDPE manufacturing. Subsequently, LDPE films with PAC/SE particles were manufactured in coupons that represented a typical juice package, and experiments indicated that these films absorbed 3.57 mg of oxygen in 11 days. This amount corresponded to 80% the concentration of oxygen in the headspace of the package. Furthermore, findings indicated that active particles alone have 10 times higher oxygen absorption capacity than the active LDPE film. Finally, the physical properties of the film were characterized by microscopy where oxygen scavengers showed a good dispersion within the matrix. However, 20 wt.% of these active particles decreased tensile strength of the film by 53%. Copyright © 2014 John Wiley & Sons, Ltd.     

Loxin Reduced the Inflammatory Response in the Liver and the Aortic Fatty Streak Formation in Mice Fed with a High-Fat Diet

Oxidized low-density lipoprotein (ox-LDL) is the most harmful form of cholesterol associated with vascular atherosclerosis and hepatic injury, mainly due to inflammatory cell infiltration and subsequent severe tissue injury. Lox-1 is the central ox-LDL receptor expressed in endothelial and immune cells, its activation regulating inflammatory cytokines and chemotactic factor secretion. Recently, a Lox-1 truncated protein isoform lacking the ox-LDL binding domain named LOXIN has been described. We have previously shown that LOXIN overexpression blocked Lox-1-mediated ox-LDL internalization in human endothelial progenitor cells in vitro. However, the functional role of LOXIN in targeting inflammation or tissue injury in vivo remains unknown. In this study, we investigate whether LOXIN modulated the expression of Lox-1 and reduced the inflammatory response in a high-fat-diet mice model. Results indicate that human LOXIN blocks Lox-1 mediated uptake of ox-LDL in H4-II-E-C3 cells. Furthermore, in vivo experiments showed that overexpression of LOXIN reduced both fatty streak lesions in the aorta and inflammation and fibrosis in the liver. These findings were associated with the down-regulation of Lox-1 in endothelial cells. Then, LOXIN prevents hepatic and aortic tissue damage in vivo associated with reduced Lox-1 expression in endothelial cells. We encourage future research to understand better the underlying molecular mechanisms and potential therapeutic use of LOXIN.     

Improved bushing models for general multibody systems and vehicle dynamics

The development and computational implementation, on a multibody dynamics environment, of a constitutive relation to model bushing elements associated with mechanical joints used in the models of road and rail vehicles is presented here. These elements are used to eliminate vibrations in vehicles, due to road irregularities, to allow small misalignment of axes, to reduce noise from the transmission, or to decrease wear of the mechanical joints. Bushings are made of a special rubber, used generally in energy dissipation, which presents a nonlinear viscoelastic relationship between the forces and moments and their corresponding displacements and rotations. In the methodology proposed here a finite element model of the bushing is developed in the framework of the finite element code ABAQUS to obtain the constitutive relations of displacement/rotation versus force/moment for different loading cases. The bushing is modeled in a multibody code as a nonlinear restrain that relates the relative displacements between the bodies connected with the joint reaction forces, and it is represented by a matrix constitutive relation. The basic ingredients of the multibody model are the same vectors and points relations used to define kinematic constraints in any multibody formulation. One particular, and relevant, characteristic of the formulation now presented is its ability to represent standard kinematic joints, clearance, and bushing joints just by defining appropriate constitutive relations. Spherical, revolution, cylindrical, and translational bushing joints are modeled, implemented, and demonstrated through the simulation of two multibody models of a road vehicle, one with perfect kinematic joints for the suspension sub-systems, and other with bushing joints. The tests conducted include an obstacle avoidance maneuver and a vehicle riding over bumps. It is shown that the bushing models for vehicle multibody models proposed here are accurate and computationally efficient so that they can be included in the vehicle models leading reliable simulations.     

Identification of Structural and Molecular Signatures Mediating Adaptive Changes in the Mouse Kidney in Response to Pregnancy

Pregnancy is characterized by adaptations in the function of several maternal body systems that ensure the development of the fetus whilst maintaining health of the mother. The renal system is responsible for water and electrolyte balance, as well as waste removal. Thus, it is imperative that structural and functional changes occur in the kidney during pregnancy. However, our knowledge of the precise morphological and molecular mechanisms occurring in the kidney during pregnancy is still very limited. Here, we investigated the changes occurring in the mouse kidney during pregnancy by performing an integrated analysis involving histology, gene and protein expression assays, mass spectrometry profiling and bioinformatics. Data from non-pregnant and pregnant mice were used to identify critical signalling pathways mediating changes in the maternal kidneys. We observed an expansion of renal medulla due to proliferation and infiltration of interstitial cellular constituents, as well as alterations in the activity of key cellular signalling pathways (e.g., AKT, AMPK and MAPKs) and genes involved in cell growth/metabolism (e.g., Cdc6, Foxm1 and Rb1) in the kidneys during pregnancy. We also generated plasma and urine proteomic profiles, identifying unique proteins in pregnancy. These proteins could be used to monitor and study potential mechanisms of renal adaptations during pregnancy and disease.