The effectiveness of counseling groups in reducing stress of parents of children with learning disabilities.

This study investigated the impact of counseling groups as compared with educational groups on attitudes, levels of stress, and sense of control among parents of a child with learning disabilities (LD) and a non-LD sibling. Conducted in one learning center in Israel, the study comprised 49 families in the counseling group and 46 families in the educational group. Results of the hierarchical analyses (mixed models) indicated significantly higher gains in the counseling groups for both mothers (who participated in the intervention) and fathers (who did not), mostly with respect to the child with LD. Children's self-reports supported these gains. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

What lies behind chemotherapy-induced ovarian toxicity?

Seminal advances in anticancer therapy as well as supportive care strategies have led to improved survival rates, posing an emphasis on preserving an optimum quality of life after cancer treatment. This recognition has paved the way to an increasing research of long-term side effects, both clinical and preclinical and to an ongoing design of a supportive care system to evaluate and treat long-term adverse effects of anticancer treatments, including the impact on fertility. As with many adverse effects induced by anticancer treatments, the literature comprised mostly clinical data with regard to chemotherapy-induced gonadotoxicity, while understanding of the biological mechanism is lagging. The impact of anticancer treatments on female fertility depends on the women's age at the time of treatment, the chemotherapy protocol, the duration, and total cumulative dose administered. Several suggested mechanisms that underlie chemotherapy-induced gonadotoxicity have been described. This review illustrates the clinical evidence, as well as its supportive preclinical studies, while proceeding from the 'bedside to the bench work' and provides an insight to what lies behind chemotherapy-induced gonadotoxicity.     

"Objective and subjective work monotony: Effects on job satisfaction, psychological distress, and absenteeism in blue-collar workers": Correction.

Reports an error in the original article by S. Melamed et al (Journal of Applied Psychology, 1995[Feb], Vol 80[1], 29–42). The last two numerical entries in the Long-cycle RW vs. VW row in Table 3 were incorrect. The corrected table, which also includes a clarification to Footnote a, is presented. (The following abstract of this article originally appeared in record 1995-23399-001). The relation of objective work conditions (work underload, repetitive or varied work) and subjective monotony to job satisfaction, psychological distress, and sickness absence was examined in 1,278 male and female workers. Subjective monotony was moderately related to the objective work conditions. Hierarchical regression analyses showed that the effects on all outcomes were partially mediated by subjective monotony and were also directly related to repetitive work and work underload. Job satisfaction and psychological distress were mainly related to subjective monotony, whereas sickness absence was equally related to the work conditions and subjective monotony. The highest impact was observed for short-cycle repetitive work. Testing sex interactions revealed that sickness absence was related to the work conditions in women but not in men… (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Improved Practical Attacks on Round-Reduced Keccak

The Keccak hash function is the winner of NIST’s SHA-3 competition, and so far it showed remarkable resistance against practical collision finding attacks: After several years of cryptanalysis and a lot of effort, the largest number of Keccak rounds for which actual collisions were found was only 2. In this paper, we develop improved collision finding techniques which enable us to double this number. More precisely, we can now find within a few minutes on a single PC actual collisions in the standard Keccak-224 and Keccak-256, where the only modification is to reduce their number of rounds to 4. When we apply our techniques to 5-round Keccak, we can get in a few days near collisions, where the Hamming distance is 5 in the case of Keccak-224 and 10 in the case of Keccak-256. Our new attack combines differential and algebraic techniques, and uses the fact that each round of Keccak is only a quadratic mapping in order to efficiently find pairs of messages which follow a high probability differential characteristic. Since full Keccak has 24 rounds, our attack does not threaten the security of the hash function.     

Complex Effects of Sertraline and Citalopram on In Vitro Murine Breast Cancer Proliferation and on In Vivo Progression and Anxiety Level

Some selective serotonin reuptake inhibitors (SSRIs), primarily sertraline, demonstrate anti-proliferative activity in malignant cell-lines and in xenografted mouse models of colorectal tumor. There is, however, a paucity of comparative studies on the anti-tumor effects of SSRIs. We compared the in vitro and in vivo effects of sertraline and citalopram on murine 4T1 breast cancer. Grafted mice were used to determine the rate of tumor growth and survival as well as the impact of stress and antidepressant treatment on tumor progression and mortality and on pro-inflammatory cytokines. Sertraline, in the micromolar range, but not citalopram, induced a significant in vitro concentration-dependent inhibition of murine 4T1 cell proliferation and splenocyte viability. In contrast, sertraline (10 mg/kg/d), enhanced in vivo tumor growth. Contrary to the study’s hypothesis, chronic mild stress did not modify tumor growth in grafted mice. The in vitro effects of sertraline on tumor growth seem to be the opposite of its in vivo effects. The impact of sertraline treatment on humans with breast cancer should be further investigated.     

An Engineered Nanocomplex with Photodynamic and Photothermal Synergistic Properties for Cancer Treatment

Photodynamic therapy (PDT) and photothermal therapy (PTT) are promising therapeutic methods for cancer treatment; however, as single modality therapies, either PDT or PTT is still limited in its success rate. A dual application of both PDT and PTT, in a combined protocol, has gained immense interest. In this study, gold nanoparticles (AuNPs) were conjugated with a PDT agent, meso-tetrahydroxyphenylchlorin (mTHPC) photosensitizer, designed as nanotherapeutic agents that can activate a dual photodynamic/photothermal therapy in SH-SY5Y human neuroblastoma cells. The AuNP-mTHPC complex is biocompatible, soluble, and photostable. PDT efficiency is high because of immediate reactive oxygen species (ROS) production upon mTHPC activation by the 650-nm laser, which decreased mitochondrial membrane potential (^∆ψ_m). Likewise, the AuNP-mTHPC complex is used as a photoabsorbing (PTA) agent for PTT, due to efficient plasmon absorption and excellent photothermal conversion characteristics of AuNPs under laser irradiation at 532 nm. Under the laser irradiation of a PDT/PTT combination, a twofold phototoxicity outcome follows, compared to PDT-only or PTT-only treatment. This indicates that PDT and PTT have synergistic effects together as a combined therapeutic method. Our study aimed at applying the AuNP-mTHPC approach as a potential treatment of cancer in the biomedical field.     

Peak-to-average power ratio in high-order OFDM

The problem of peak-to-average power ratio (PAPR) of high-order orthogonal frequency-division modulation (OFDM) is considered. Using results on level crossing of random processes, an upper bound on the probability that the PAPR of an OFDM signal will exceed a given value is derived. Numerical computations are used to show that this bound is tight for low-pass OFDM systems. The central limit theorem is used to find an asymptotic expression for the bound when the number of carriers N grows to infinity. The central limit theorem is also used to find an asymptotic expression for another bound that is based on the envelope of the OFDM signal, and is tighter for bandpass systems. It is shown that, effectively, the PAPR grows as 2lnN and not linearly with N, and by developing a lower bound on the probability that the PAPR of an OFDM signal will exceed a given value, it is shown that asymptotically most OFDM symbols have a PAPR close to 2lnN. Some approaches to coping with the PAPR problem are discussed in light of the obtained results     

PCP Characterizations of NP: Toward a Polynomially-Small Error-Probability

This paper strengthens the low-error PCP characterization of NP, coming closer to the upper limit of the BGLR conjecture. Consider the task of verifying a written proof for the membership of a given input in an NP language. In this paper, this is achieved by making a constant number of accesses to the proof, obtaining error probability that is exponentially small in the total number of bits that are read.     

Why and how can human-related measures support software development processes?

In this paper we discuss why and how measures related to human aspects should be incorporated into software development processes. This perspective is based on the vast evidence that human aspects are the source of the majority of problems associated with software development projects. Having said that, we do not blame the humans involved in software development processes; rather, we suggest that human-related measures might be one means by which human aspects of software development processes can be supported.