On the implementation of the Opus coordination language

Opus is a new programming language designed to assist in coordinating the execution of multiple, independent program modules. With the help of Opus, coarse grained task parallelism between data parallel modules can be expressed in a clean and structured way. In this paper we address the problems of how to build a compilation and runtime support system that can efficiently implement the Opus constructs. Our design considers the often‐conflicting goals of efficiency and modular construction through software re‐use. In particular, we present the system requirements for an efficient Opus implementation, the Opus runtime system, and describe how they work together to provide the underlying services that the Opus compiler needs for a broad class of machines. Copyright © 2000 John Wiley & Sons, Ltd.     

Measuring Local Crystallization Fouling in a Double-Pipe Heat Exchanger

Abstract

Although fouling is a problem varying in space and time, sizing and assessment of a process apparatus is almost always based on one single integral fouling resistance value. Furthermore, the integral fluid dynamic behavior, e.g. the development of time-dependent pressure drop in a heat exchanger, can be influenced by local constrictions. While it is generally possible to determine the time dependency of the integral fouling behavior, local differences are not taken into consideration at present. Therefore, this paper introduces a metrological, an incremental and a segmental approach to study the local development of crystallization fouling by calcium sulfate in a countercurrent double-pipe heat exchanger. The consecutive approaches allow for thermal, volumetric, gravimetric, and optical fouling investigations, aiming to examine the axial distribution of deposit as well as local differences in the deposit morphology. All methods provided congruent results and local fouling could be described properly. An almost clean surface at the colder end of the heat exchanger and an exponential increase of deposit thickness were observed towards the hot end. Hence, the section near to the hot water inlet turned out to be a key area with regards to increasing fouling mass and structural changes of the layer.     

Dual Knockdown of Musashi RNA-Binding Proteins MSI-1 and MSI-2 Attenuates Putative Cancer Stem Cell Characteristics and Therapy Resistance in Ovarian Cancer Cells

In ovarian cancer, therapy resistance mechanisms complicate cancer cell eradication. Targeting Musashi RNA-binding proteins (MSI) may increase therapeutic efficacy. Database analyses were performed to identify gene expression associations between MSI proteins and key therapy resistance and cancer stem cell (CSC) genes. Then, ovarian cancer cells were subjected to siRNA-based dual knockdown of MSI-1 and MSI-2. CSC and cell cycle gene expression was investigated using quantitative polymerase chain reaction (qPCR), western blots, and flow cytometry. Metabolic activity and chemoresistance were assessed by MTT assay. Clonogenic assays were used to quantify cell survival post-irradiation. Database analyses demonstrated positive associations between MSI proteins and putative CSC markers NOTCH, MYC, and ALDH4A1 and negative associations with NOTCH inhibitor NUMB. MSI-2 expression was negatively associated with the apoptosis regulator p21. MSI-1 and MSI-2 were positively correlated, informing subsequent dual knockdown experiments. After MSI silencing, CSC genes were downregulated, while cell cycle progression was reduced. Metabolic activity was decreased in some cancer cells. Both chemo- and radioresistance were reduced after dual knockdown, suggesting therapeutic potential. Dual knockdown of MSI proteins is a promising venue to impede tumor growth and sensitize ovarian cancer cells to irradiation and chemotherapy.     

BCOOPL: Basic concurrent object‐oriented programming language

A small, object‐oriented language is introduced: BCOOPL (Basic Concurrent Object‐Oriented Programming Language). This language is specifically targeted to support component‐oriented programming. The main design goal of BCOOPL was to provide a small, but powerful set of language features that supports the construction of high‐quality components through well‐established software engineering practices, which include the separation of interfaces and implementations, weakly‐coupled objects, and abstraction. A number of design patterns based on these principles is actually built in the language. In particular, the observer, the mediator and the bridge are supported directly. This provides a strong foundation on which higher level component specification languages can be built. BCOOPL has a long research history. Its roots can be traced back to path expressions, and the concurrent object‐oriented programming languages Procol and Talktalk. As a result, BCOOPL only integrates essential language features that blend well and have proven their value in practice. Copyright © 2000 John Wiley & Sons, Ltd.     

Flash Evaporation

Die Flash‐Verdampfung ist eine Ein‐Quellen‐Verdampfungstechnik, welche in relativ einfacher Weise die Aufdampfung komplexer, multikomponenter Schichtmaterialien ermöglicht. Dazu ist aber eine spezielle Vorrichtung und eine spezielle Materialaufbereitung des Schichtmaterials notwendig.