Extraction optimisation,antioxidant activity and inhibition on α-amylase and pancreatic lipase of polyphenols from the seeds of Syzygium cumini

The objectives of this study were to determine the optimal extraction conditions of polyphenols from Syzygium cumini seeds by response surface methodology and investigate their antioxidant activity and inhibition on α-amylase and pancreatic lipase. As results, the optimal extraction conditions in the ultrasonic extraction process which maximised total polyphenols content, minimised the IC₅₀ values of α-amylase and pancreatic lipase were determined as follows: extraction time 60 min, ethanol concentration 63% and solvent/solid ratio 44 mL g⁻¹. The main phenolic compounds in partially purified fraction of Syzygium cumini seeds were catechin, epicatechin, kaempferol, gallic, 5-caffeoylquinic, caffeic and ferulic acids. In addition, the partially purified fraction inhibited 87.66 ± 5.55 and 86.61 ± 3.15% of α-amylase and pancreatic lipase, respectively. The results suggested that Syzygium cumini seeds could be explored as a natural antioxidant and could be used as a source of highly antidiabetic and anti-obesity bioactive compounds.     

Pressure-driven reverse-phase liquid chromatography separations in ordered nonporous pillar array columns

Building upon the micromachined column idea proposed by the group of Regnier in 1998, we report on the first high-resolution reversed-phase separations in micromachined pillar array columns under pressure-driven LC conditions. A three component mixture could be separated in 3 s using arrays of nonporous silicon pillars with a diameter of approximately 4.3 microm and an external porosity of 55%. Under slightly retained component conditions (retention factor k' = 0.65-1.2), plate heights of about H = 4 microm were obtained at a mobile phase velocity around u = 0.5 mm/s. In reduced terms, such plate heights are as low as hmin = 1. Also, since the flow resistance of the column is much smaller than in a packed column (mainly because of the higher external porosity of the pillar array), the separation impedance of the array was as small as E = 150, i.e., of the same order as the best currently existing monolithic columns. At pH = 3, yielding very low retention factors (k' = 0.13 and 0.23), plate heights as low as H = 2 microm were realized, yielding a separation of the three component mixture with an efficiency of N = 4000-5000 plates over a column length of 1 cm. At higher retention factors, significantly larger plate heights were obtained. More experimental work is needed to investigate this more in depth. The study is completed with a discussion of the performance limits of the pillar array column concept in the frame of the current state-of-the-art in microfabrication precision.     

Nonlinear analysis of an elastic cable under harmonic excitation

The nonlinear behavior of an elastic cable subjected to harmonic excitation is studied and solved. The method of multiple scales perturbation is applied to analyze the response of the nonlinear system near the simultaneous principle primary and internal resonance. The stability of the proposed analytic nonlinear solution near the simultaneous primary-internal resonance is studied and the stability condition is investigated. The effect of different parameters on the steady state responses of the vibrating system is studied and discussed using frequency response equations. The numerical solutions and chaotic response of the nonlinear system of the elastic cable for different parameters are also studied.     

Design and Analysis of a Channel Assignment Scheme for CDMA/TDMA Mobile Networks

In this paper, a channel assignment scheme is proposed for use in CDMA/TDMA mobile networks carrying voice and data traffic. In each cell, three types of calls are assumed to compete for access to the limited number of available channels by the cell: new voice calls, handoff voice calls, and data calls. The scheme uses the movable boundary concept in both the code and time domains in order to guarantee the quality of service (QoS) requirements of each type. A traditional Markov analysis method is employed to evaluate the performance of the proposed scheme. Measures, namely, the new call blocking probability, the handoff call forced termination probability, the data call loss probability, the expected number of handoff and the handoff link maintenance probability are obtained from the analysis. The numerical results, which are validated by simulation, indicate that the scheme helps meet the QoS requirements of the different call types.     

Energy‐efficient void avoidance geographic routing protocol for underwater sensor networks

Underwater wireless sensor networks (UWSNs) consist of a group of sensors that send the information to the sonobuoys at the surface level. Void area, however, is one of the challenges faced by UWSNs. When a sensor falls in a void area of communication, it causes problems such as high latency, power consumption, or packet loss. In this paper, an energy‐efficient void avoidance geographic routing protocol (EVAGR) has been proposed to handle the void area with low amount of energy consumption. In this protocol, a suitable set of forwarding nodes is selected using a weight function, and the data packets are forwarded to the nodes inside the set. The weight function includes the consumed energy and the depth of the candidate neighboring nodes, and candidate neighboring node selection is based on the packet advancement of the neighboring nodes toward the sonobuoys. Extensive simulation experiments were performed to evaluate the efficiency of the proposed protocol. Simulation results revealed that the proposed protocol can effectively achieve better performance in terms of energy consumption, packet drop, and routing overhead compared with the similar routing protocol.     

Thermal analysis of above-grade wall assembly with low emissivity materials and furred airspace

A 3D numerical model was developed to investigate the effect of foil emissivity on the effective thermal resistance of an above-grade wall assembly with foil bonded to wood fibreboard in a furred assembly having airspace next to the foil. This model solved simultaneously the energy equation in the various material layers, the surface-to-surface radiation equation in the furred airspace assembly, Navier–Stokes equation for the airspace, and Darcy and the Brinkman equations for the porous material layers. In this work, the furring was installed horizontally. In the first phase, the present model was benchmarked against the experimental data generated by a commercial laboratory for an above-grade wall assembly. The wall consists of a conventional wood frame structure sheathed with fibreboard and covered on the interior side with a low emissivity material bonded to wood fibreboard that is adjacent to a furred airspace assembly. The results showed that the predicted R-value was in good agreement with the measured one. After gaining confidence in the present model, it was used to predict the effective thermal resistance of the same above-mentioned wall but having Oriented Strand Board (OSB) sheathing in lieu of wood fibreboard sheathing. In the second phase, the model was used to quantify the contribution on the wall R-value by having a low foil emissivity. The results showed that a low foil emissivity of 0.04 can increase the R-value of this wall to as much as ∼9%. This is on-going research. The present model is being used to investigate the transient thermal response of foundation wall systems with furring installed horizontally and vertically, and subjected to different Canadian climate conditions.     

Electrodes based on nano-tree-like vanadium nitride and carbon nanotubes for micro-supercapacitors

Vanadium nitride(VN) was deposited by DC-sputtering on a vertically aligned carbon nanotube(CNTs)template for the purpose of nano-structuration. This led to the fabrication of hierarchically composite electrodes consisting of porous and nanostructured VN grown on vertically aligned CNTs in a nano-treelike configuration for micro-supercapacitor application. The electrodes show excellent performance with an areal capacitance as high as 37.5 m F cm~(-2) at a scan rate of 2 mV s~(-1) in a 0.5 MK_2SO_4 mild electrolyte solution. Furthermore, the capacitance decay was only 15% after 20,000 consecutive cycles. Moreover,the capacitance was found to increase with VN deposit thickness. The X-ray photoelectron spectroscopy analyses of the electrodes before and after cycling suggest that the oxide layers that form at the VN surface is the responsible for the redox energy storage in this material. Such electrodes can compete with other transition metal nitride based electrodes for micro-supercapacitors.     

Improving the physical and mechanical properties of particleboards made from urea–glyoxal resin by addition of pMDI

The effect of pMDI on physical and mechanical properties of the particleboards made from urea–glyoxal resin was investigated. The nontoxic and ecofriendly urea–glyoxal (UG) resin was synthesized under weak acid conditions, and its different properties were measured. Then, pMDI at various contents (4, 6 and 8% on resin solids) was added to the UG resin prepared. The thermal and physicochemical properties of the resins prepared as well as their water absorption, flexural properties (flexural modulus and strength) and internal bond (IB) strength of the particleboard panels bonded with them were measured according to standard methods. According to the physicochemical results obtained, the addition of pMDI significantly accelerated the gel time and increased the viscosity and solids content of UG resins. Differential scanning calorimetry indicated that the addition of pMDI decreases the onset and curing temperatures of the UG resin. Physical analysis results of the panels indicated that the particleboards made from UG resins with isocyanate yielded lower water absorption when compared to those bonded with the control UG resins. Based on the findings of this research work, the mechanical properties of particleboard panels bonded with UG resins could be significantly enhanced by the addition of increasing percentages of pMDI. The panels having 8 wt% pMDI exhibited the highest flexural modulus, flexural strength and IB strength value and the lowest water absorption among all the panels prepared.     

Analysis of multistage amplifiers with hybrid cascode feedforward compensation using a modified model for load impedance

Hybrid cascode feedforward compensation (HCFC) is an effective technique to stabilize nano-scale three-stage amplifiers driving ultra-large load capacitors. It divides the compensation capacitance and shares it between two high-speed local feedback loops embedded within the amplifier core. In this article, a systematic approach to analyze the transfer function and to evaluate the pole expressions of nano-scale HCFC amplifiers is presented. For the first time, the equivalent output impedance is successfully modeled to approximate the complicated transfer function of the HCFC amplifier without the need for lengthy pencil-and-paper calculations. An HCFC amplifier is designed and simulated in 90-nm CMOS technology, to verify the effectiveness of the new analytic approach. The simulated transfer function of the amplifier is almost identical to a calculated transfer function derived based on the new model.     

A novel algorithm to study the impact of the mismatch on analog building blocks: a case study in basic 35 nm CMOS amplifiers

In this paper, the context of modeling of the impact of mismatch and statistical variations on analogue circuit building blocks is emphasized. The aim is to develop a new algorithm which predicts the statistical behavior of important parameters of an amplifier including output resistance, voltage gain and trans-conductance. The relative error of standard deviation of statistical parameters will remain less than 5% compared with the most accurate Monte-Carlo (MC) simulations using atomistic library model-cards. In comparison with other models which are based on the normal distribution of parameters, the proposed model does not need this limiting presumption. On the other hand, the proposed algorithm is more efficient compared with time consuming MC atomistic simulations.