全文获取类型
收费全文 | 243759篇 |
免费 | 2740篇 |
国内免费 | 445篇 |
学科分类
工业技术 | 246944篇 |
出版年
2021年 | 2233篇 |
2019年 | 2134篇 |
2018年 | 3640篇 |
2017年 | 3563篇 |
2016年 | 3808篇 |
2015年 | 2318篇 |
2014年 | 3991篇 |
2013年 | 10421篇 |
2012年 | 6297篇 |
2011年 | 8457篇 |
2010年 | 6667篇 |
2009年 | 7381篇 |
2008年 | 7740篇 |
2007年 | 7821篇 |
2006年 | 6964篇 |
2005年 | 6100篇 |
2004年 | 5857篇 |
2003年 | 5636篇 |
2002年 | 5698篇 |
2001年 | 5577篇 |
2000年 | 5399篇 |
1999年 | 5312篇 |
1998年 | 12598篇 |
1997年 | 8911篇 |
1996年 | 6864篇 |
1995年 | 5334篇 |
1994年 | 4744篇 |
1993年 | 4634篇 |
1992年 | 3682篇 |
1991年 | 3400篇 |
1990年 | 3601篇 |
1989年 | 3478篇 |
1988年 | 3307篇 |
1987年 | 2902篇 |
1986年 | 2941篇 |
1985年 | 3379篇 |
1984年 | 3225篇 |
1983年 | 2893篇 |
1982年 | 2743篇 |
1981年 | 2827篇 |
1980年 | 2719篇 |
1979年 | 2627篇 |
1978年 | 2685篇 |
1977年 | 2949篇 |
1976年 | 3808篇 |
1975年 | 2369篇 |
1974年 | 2243篇 |
1973年 | 2377篇 |
1972年 | 1970篇 |
1971年 | 1859篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
11.
Joo H. Kang Eujin Um Alexander Diaz Harry Driscoll Melissa J. Rodas Karel Domansky Alexander L. Watters Michael Super Howard A. Stone Donald E. Ingber 《Small (Weinheim an der Bergstrasse, Germany)》2015,11(42):5657-5666
Magnetic nanoparticles have been employed to capture pathogens for many biological applications; however, optimal particle sizes have been determined empirically in specific capturing protocols. Here, a theoretical model that simulates capture of bacteria is described and used to calculate bacterial collision frequencies and magnetophoretic properties for a range of particle sizes. The model predicts that particles with a diameter of 460 nm should produce optimal separation of bacteria in buffer flowing at 1 L h−1. Validating the predictive power of the model, Staphylococcus aureus is separated from buffer and blood flowing through magnetic capture devices using six different sizes of magnetic particles. Experimental magnetic separation in buffer conditions confirms that particles with a diameter closest to the predicted optimal particle size provide the most effective capture. Modeling the capturing process in plasma and blood by introducing empirical constants (ce), which integrate the interfering effects of biological components on the binding kinetics of magnetic beads to bacteria, smaller beads with 50 nm diameters are predicted that exhibit maximum magnetic separation of bacteria from blood and experimentally validated this trend. The predictive power of the model suggests its utility for the future design of magnetic separation for diagnostic and therapeutic applications. 相似文献
12.
Biological information is stored in DNA, RNA and protein sequences, which can be understood as genotypes that are translated into phenotypes. The properties of genotype–phenotype (GP) maps have been studied in great detail for RNA secondary structure. These include a highly biased distribution of genotypes per phenotype, negative correlation of genotypic robustness and evolvability, positive correlation of phenotypic robustness and evolvability, shape-space covering, and a roughly logarithmic scaling of phenotypic robustness with phenotypic frequency. More recently similar properties have been discovered in other GP maps, suggesting that they may be fundamental to biological GP maps, in general, rather than specific to the RNA secondary structure map. Here we propose that the above properties arise from the fundamental organization of biological information into ‘constrained'' and ‘unconstrained'' sequences, in the broadest possible sense. As ‘constrained'' we describe sequences that affect the phenotype more immediately, and are therefore more sensitive to mutations, such as, e.g. protein-coding DNA or the stems in RNA secondary structure. ‘Unconstrained'' sequences, on the other hand, can mutate more freely without affecting the phenotype, such as, e.g. intronic or intergenic DNA or the loops in RNA secondary structure. To test our hypothesis we consider a highly simplified GP map that has genotypes with ‘coding'' and ‘non-coding'' parts. We term this the Fibonacci GP map, as it is equivalent to the Fibonacci code in information theory. Despite its simplicity the Fibonacci GP map exhibits all the above properties of much more complex and biologically realistic GP maps. These properties are therefore likely to be fundamental to many biological GP maps. 相似文献
13.
14.
The tracer methods developed to assess exfiltration from sewers in the European project APUSS (assessment of the performance of sewer systems) have a high degree of freedom with regard to the choice of tracer and the dosing strategy. These can lead to very different degrees of uncertainty in the measured exfiltration ratio. In this study, we demonstrate how to select an optimal experimental design using decision analysis, which accounts for this uncertainty and its associated costs. Although the results are site-specific, we can conclude generally that, when NaCl is used as the tracer, the accuracy of the exfiltration estimate is most sensitive to the amount of tracer used and the starting time of the experiment. 相似文献
15.
A GIS-based one-dimensional flood simulation model is presented and applied to the centre of the city of N?mes (Gard, France), for mapping flow depths or velocities in the streets network. The geometry of the one-dimensional elements is derived from the Digital Elevation Model (DEM). The flow is routed from one element to the next using the kinematic wave approximation. At the crossroads, the flows in the downstream branches are computed using a conceptual scheme. This scheme was previously designed to fit Y-shaped pipes junctions, and has been modified here to fit X-shaped crossroads. The results were compared with the results of a two-dimensional hydrodynamic model based on the full shallow water equations. The comparison shows that good agreements can be found in the steepest streets of the study zone, but differences may be important in the other streets. Some reasons that can explain the differences between the two models are given and some research possibilities are proposed. 相似文献
16.
D. A. Mirzaev N. I. Vorob’ev O. K. Tokovi D. V. Shaburov E. A. Fominykh 《Russian Metallurgy (Metally)》2006,(1):38-41
The solutions to a differential equation for the problem of heating of a cylinder in a medium with a fixed temperature are used to obtain equations for estimating the change in the hydrogen concentration in forgings from data on the hydrogen concentration at the cylinder axis or on the average bulk hydrogen concentration. Similar equations are also obtained for forgings having square cross sections. The calculation demonstrates that, for the case of a twofold decrease in the hydrogen concentration in a forging, the calculated times of annealing of a cylindrical forging differ by three times. 相似文献
17.
Finite element analysis of problems in structural and geotechnical engineering results in linear systems where the unknowns are displacements and rotations at nodes. Although the solution of these systems can be carried out using either direct or iterative methods, in practice the matrices involved are usually very large and sparse (particularly for 3D problems) so an iterative approach is often advantageous in terms of both computational time and memory requirements. This memory saving can be further enhanced if the method used does not require assembly of the full coefficient matrix during the solution procedure. One disadvantage of iterative methods is the need to apply preconditioning to improve convergence. In this paper, we review a range of established element-based preconditioning methods for linear elastic problems and compare their performance with a new method based on preconditioning with element displacement components. This new method appears to offer a significant improvement in performance. 相似文献
18.
Observer-based estimators (OBE) were used for estimation of state variables and kinetic parameters in an anaerobic digestion (AD) process. A simplified first-order model with time-varying kinetic parameters was used to design an OBE for kinetic parameter estimation. This approach was validated on a laboratory-scale anaerobic reactor equipped with a multiwavelength fluorometer for on-line measurements of COD and VFA concentrations in the reactor effluent. The proposed estimators provide continuous adjustment of kinetic parameters and can be used for predictions of state variables between samples acquisition and during sensor failure. 相似文献
19.
N. I. Nikolaikin E. Yu. Barzilovich N. E. Nikolaikina 《Chemical and Petroleum Engineering》2006,42(5-6):332-338
The paper discusses optimal control of ecosystem state for observation of a generalized monotonically varying random parameter.
A model is proposed for the controlled vector random process, whose components are assigned acceptable ranges and the observations
are performed discretely.
__________
Translated from Khimicheskoe i Neftegazovoe Mashinostroenie, No. 6, pp. 40–44, June, 2006. 相似文献
20.
Note on B-splines, wavelet scaling functions, and Gabor frames 总被引:3,自引:0,他引:3
Grochenig K. Janssen A.J.E.M. Kaiblinger N. Pfander G.E. 《IEEE transactions on information theory / Professional Technical Group on Information Theory》2003,49(12):3318-3320
Let g be a continuous, compactly supported function on such that the integer translates of g constitute a partition of unity. We show that the Gabor system (g,a,b), with window g and time-shift and frequency-shift parameters a,b>0 has no lower frame bound larger than 0 if b=2,3,... and a>0. In particular, (g,a,b) is not a Gabor frame if g is a continuous, compactly supported wavelet scaling function and if b=2,3,... and a>0. We give an example for our result for the case that g=B/sub 1/, the triangle function supported by [-1,1], by showing pictures of the canonical dual corresponding to (g,a,b) where ab=1/4 and b crosses the lines N=2,3,. 相似文献