Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta

How senile plaques and neurofibrillary tangles are linked represents a major gap in our understanding of the pathophysiology of Alzheimer's disease. We characterized a hippocampal neuronal culture system in which tau undergoes maturation in vivo; rat neurons maintained in culture for more than 3 weeks replicated the splicing and phosphorylation changes that tau undergoes upon maturation in situ. Using this model system, we induced an Alzheimer-like neuritic dystrophy following the application of fibrillar beta-amyloid. The dystrophy consisted of focal distortions and swellings within the neurites and an altered phosphorylation of the adult tau isoforms. Fibrillar beta-amyloid induced the concomitant activation of MAP kinase and GSK3 beta. The aberrant activation of several signaling pathways may lead to the abnormal phosphorylation of tau and neuritic degeneration.     

Protruded lumbar intervertebral nucleus pulposus in a 12-year-old girl who recovered after nonsurgical treatment: a follow-up case report

Restless legs syndrome affects millions, but most healthcare providers don't know it exists. Its sleep-deprived victims are plagued by indescribable crawling sensations in their legs that occur at night and that are only relieved by moving the legs. Many home healthcare clients, already challenged by their primary illness, are also affected by the persistent symptoms of Restless Legs Syndrome. It is important that home care nurses learn about Restless Legs Syndrome-what it is, how to assess it, and what can be done about it.     

活塞综合检测仪的研制

介绍了活塞综合检测仪的功能、组成、检测过程、测量原理与方法和主要技术性能指标。该仪器是国内研制的第一台智能型活塞综合检测仪。实际应用表明,这是一台高精度、高稳定性和高效率的检测仪器。     

简易炉外处理在电炉钢生产中的应用

阐述了小电炉采用投资少，见较快，简单易行的炉外处理措施，提高了钢质量和生产率，生产实践和应用结果表明，本措施可为同类型企业的炼钢工艺完善和技术进步提供参考。     

多信道光纤环形网络结构分析

本文对多信道光纤环形网络结构进行了详细分析，推导出环网内平均路经长度和最大直径计算公式，并分析了最佳多信道光纤环网结构。     

求最佳配比的模拟压缩算法

研究了无放大效应的生产过程中各原料的配比问题，建立了一种模拟压缩模型，给出了求最佳配比的算法。     

关于龙滩水电站碾压混凝土坝的抗剪断强度问题

本文就龙滩水电站碾压混凝土坝的抗剪断强度进行了叙述，认为所提出各项指标是合理的，但要满足这些指标必须采取一定的措施，以确保大坝的安全度     

西北地区节水灌溉市场与技术需求

西部开发需要大量的生态用水，从节水灌溉设备市场分析，节水灌溉专用泵阀、新型输水管材、高效低能喷微灌设备及材料的需求量很大，技术需求与亟待研究开发的关键技术和设备也很多。从西北地区水资源状况与需求看，节水灌溉市场有很大潜力。     

军事卫星通信系统的发展趋势

卫星通信在C~3I系统中将发挥越来越重要的作用,而目前卫星通信又处在一个大发展的时期,可以预计在未来的十年到二十年间卫星通信将面临许多重大变革。论文从四个方面论述了军事卫星通信系统的发展趋势。     

神经网络用于三元分子混合物密度与粘度的预测

以二元系实验为基础，利用反向转播算法训练神经网络，构造混合物组成，温度等与物性关系的模型，用于对４个三元混合物体系（１）邻二甲苯－间二甲苯－对二甲苯；（２）四氯化碳－环己烷－２－丙醇；（３）甲醇－丙酮－水；（４）水－甲醇－乙二醇的密度和５个三元混合物体系（１）信甲苯－间二甲苯－对二甲苯；（２）四氯化碳－环己烷－２－丙醇；（３）氯仿－２－丙醇－２－丁醇；（４）甲醇－丙酮－水；（５）乙醇－甲醇－水的粘