Personalization in cultural heritage: the road travelled and the one ahead

Over the last 20?years, cultural heritage has been a favored domain for personalization research. For years, researchers have experimented with the cutting edge technology of the day; now, with the convergence of internet and wireless technology, and the increasing adoption of the Web as a platform for the publication of information, the visitor is able to exploit cultural heritage material before, during and after the visit, having different goals and requirements in each phase. However, cultural heritage sites have a huge amount of information to present, which must be filtered and personalized in order to enable the individual user to easily access it. Personalization of cultural heritage information requires a system that is able to model the user (e.g., interest, knowledge and other personal characteristics), as well as contextual aspects, select the most appropriate content, and deliver it in the most suitable way. It should be noted that achieving this result is extremely challenging in the case of first-time users, such as tourists who visit a cultural heritage site for the first time (and maybe the only time in their life). In addition, as tourism is a social activity, adapting to the individual is not enough because groups and communities have to be modeled and supported as well, taking into account their mutual interests, previous mutual experience, and requirements. How to model and represent the user(s) and the context of the visit and how to reason with regard to the information that is available are the challenges faced by researchers in personalization of cultural heritage. Notwithstanding the effort invested so far, a definite solution is far from being reached, mainly because new technology and new aspects of personalization are constantly being introduced. This article surveys the research in this area. Starting from the earlier systems, which presented cultural heritage information in kiosks, it summarizes the evolution of personalization techniques in museum web sites, virtual collections and mobile guides, until recent extension of cultural heritage toward the semantic and social web. The paper concludes with current challenges and points out areas where future research is needed.     

A mobility constraint model to infer sensor behaviour in forest fire risk monitoring

Wireless sensor networks (WSNs) play an important role in forest fire risk monitoring. Various applications are in operation. However, the use of mobile sensors in forest risk monitoring remains largely unexplored. Our research contributes to fill this gap by designing a model which abstracts mobility constraints within different types of contexts for the inference of mobile sensor behaviour. This behaviour is focused on achieving a suitable spatial coverage of the WSN when monitoring forest fire risk. The proposed mobility constraint model makes use of a Bayesian network approach and consists of three components: (1) a context typology describing different contexts in which a WSN monitors a dynamic phenomenon; (2) a context graph encoding probabilistic dependencies among variables of interest; and (3) contextual rules encoding expert knowledge and application requirements needed for the inference of sensor behaviour. As an illustration, the model is used to simulate the behaviour of a mobile WSN to obtain a suitable spatial coverage in low and high fire risk scenarios. It is shown that the implemented Bayesian network within the mobility constraint model can successfully infer behaviour such as sleeping sensors, moving sensors, or deploying more sensors to enhance spatial coverage. Furthermore, the mobility constraint model contributes towards mobile sensing in which the mobile sensor behaviour is driven by constraints on the state of the phenomenon and the sensing system.     

Treatment of Point Defects in Nanowire MOSFETs Using the Nonequilibrium Green’s Function Formalism

A program to numerically simulate point defects in nanowire metal-oxide-semiconductor field-effect transistors is described. The simulation scheme is based on the non-equilibrium Green’s function method self-consistently being obtained via the resolution of 3D Poisson’s equation. A tight-binding hamiltonian is used and the point defect is characterized by a macroscopic coulombic tail treated in the mode-space approach, plus a short range on-site perturbation potential energy, treated exactly. The effect on internal quantities and on the transistor characteristics is studied as a function of the strength and the location of the defect potential. Subthreshold current is found to vary in a factor 10 according to the position of the impurity.Also With Institut Universitaire De France (IUF).     

Recalling Spatial Information as a Component of Recently and Remotely Acquired Episodic or Semantic Memories: An fMRI Study.

Activations produced by the recall of episodic and semantic memories differing in spatial content and age were examined. Recall of recent episodic memories with differing spatial content activated the medial temporal lobes and the retrosplenial-posterior cingulate cortex-precuneus complex more than recall of recent semantic memories with similarly differing spatial content. Some of these differences related to the amount of spatial information recalled because spatially richer recent memories, regardless of whether they were episodic or semantic, activated the right posterior parahippocampal cortex, precuneus, and posterior parietal cortex more. This spatial effect was found to be independent of memory age for semantic memories, although some episodic-semantic memory differences, including one in the left hippocampus, were not age independent. Episodic-semantic memory recall activation differences are therefore probably a function of the amount recalled, memory age, and what is recalled, particularly with respect to spatial information. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Hierarchies of parallel rewriting P systems — A survey

The paper is about some families of rewriting P systems, where the application of evolution rules is extended from the classical sequential rewriting to the parallel one (as, for instance, in Lindenmayer systems). As a result, consistency problems for the communication of strings may arise. Three variants of parallel rewriting P systems (already present in the literature) are considered here, together with the strategies they use to face the communication problem, and some parallelism methods for string rewriting are defined. We give a survey of all known results about each variant and we state some relations among the three variants, thus establishing hierarchies of parallel rewriting P systems. Various open problems related to the subject are also presented. Danicla Besozzi: She is assistant professor at the University of Milano. She received her M.S. in Mathematics (2000) from the University of Como and Ph.D. in Computer Science (2004) from the University of Milano. Her research interests cover topics in Formal Language Theory, Molecular Computing, Systems Biology. She is member of EATCS (European Association for Theoretical Computer Science) and EMCC (European Molecular Computing Consortium). Giancarlo Mauri: He is full professor of Computer Science at the University of Milano-Bicocca. His research interests are mainly in the area of theoretical computer science, and include: formal languages and automata, computational complexity, computational learning theory, soft computing techniques, cellular automata, bioinformatics and molecular computing. On these subjects, he published more than 150 scientific papers in international journals, contributed volumes and conference proceedings. Claudio Zandron: He received Ph.D. in Computer Science at the University of Milan, Italy, in 2001. Since 2002 he is assistant professor at the University of Milano-Bicocca, Italy. He is member of the EATCS (European Association for Theoretical Computer Science) and of EMCC (European Molecular Computing Consortium). His research interests are Molecular Computing (DNA and Membrane Computing) and Formal Languages.     

Proteins as biomarkers of oxidative/nitrosative stress in diseases: the contribution of redox proteomics

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) contribute to the pathogenesis and/or progression of several human diseases. Proteins are important molecular signposts of oxidative/nitrosative damage. However, it is generally unresolved whether the presence of oxidatively/nitrosatively modified proteins has a causal role or simply reflects secondary epiphenomena. Only direct identification and characterization of the modified protein(s) in a given pathophysiological condition can decipher the potential roles played by ROS/RNS-induced protein modifications. During the last few years, mass spectrometry (MS)-based technologies have contributed in a significant way to foster a better understanding of disease processes. The study of oxidative/nitrosative modifications, investigated by redox proteomics, is contributing to establish a relationship between pathological hallmarks of disease and protein structural and functional abnormalities. MS-based technologies promise a contribution in a new era of molecular medicine, especially in the discovery of diagnostic biomarkers of oxidative/nitrosative stress, enabling early detection of diseases. Indeed, identification and characterization of oxidatively/nitrosatively modified proteins in human diseases has just begun.     

A sub-nanosecond Synchronized MAC – PHY cross-layer design for Wireless Sensor Networks

In this paper, we present a Wireless Sensor node implementation which aims at solving two major issues in Wireless Sensor Networks. This solution provides nanosecond-scale synchronization between nodes and high data-rate transmission thanks to cross-layer design and the time-domain properties of UltraWide Band (UWB) modulation schemes. The high data rate is achieved through a specific implementation of a IR-UWB physical layer. Specific algorithms are also implanted into the MAC and physical layers and form a cross-layered synchronization protocol for deterministic Wireless Sensor Networks named WiDeCS (Wireless Deterministic Clock Synchronization). This protocol propagates master time reference to nodes of a cluster tree network. WiDeCS Cross layered scheme is possible thanks to flag signals rising in the physical layer. These signals, owing to the UWB time domain properties, capture precise timestamps of transmission and reception. Hardware level simulations show a clock synchronization precision of 2 ns with a 2 GHz bandwidth signal, and an ASIC demonstrator shows 374 ps synchronization precision and 677 ps of standard deviation with the same bandwidth. In this paper, the physical layer implementation is detailed, and the cross-layered WiDeCS scheme is demonstrated.     

Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase

SMYD3 is a multifunctional epigenetic enzyme with lysine methyltransferase activity and various interaction partners. It is implicated in the pathophysiology of cancers but with an unclear mechanism. To discover tool compounds for clarifying its biochemistry and potential as a therapeutic target, a set of drug-like compounds was screened in a biosensor-based competition assay. Diperodon was identified as an allosteric ligand; its R and S enantiomers were isolated, and their affinities to SMYD3 were determined (K_D=42 and 84 μM, respectively). Co-crystallization revealed that both enantiomers bind to a previously unidentified allosteric site in the C-terminal protein binding domain, consistent with its weak inhibitory effect. No competition between diperodon and HSP90 (a known SMYD3 interaction partner) was observed although SMYD3–HSP90 binding was confirmed (K_D=13 μM). Diperodon clearly represents a novel starting point for the design of tool compounds interacting with a druggable allosteric site, suitable for the exploration of noncatalytic SMYD3 functions and therapeutics with new mechanisms of action.     

Salmonella in eggs: From shopping to consumption—A review providing an evidence-based analysis of risk factors

Nontyphoidal salmonellae are among the most prevalent foodborne pathogens causing gastrointestinal infections worldwide. A high number of cases and outbreaks of salmonellosis are associated with the consumption of eggs and egg products, and several of these occur at the household level. The aim of the current study is to critically evaluate the current status of knowledge on Salmonella in eggs from a consumer's perspective, analyzing the hazard occurrence and the good practices that should be applied to reduce salmonellosis risk. Following a HACCP (Hazard Analysis and Critical Control Point) based approach, some steps along the food journey were identified as Critical Consumer Handling (CCH)—steps in which consumers, through their behavior or choice, can significantly reduce the level of Salmonella in eggs and egg products. From shopping/collecting to consumption, each of these steps is discussed in this review to provide an evidence-based overview of risk factors of human salmonellosis related to egg consumption. The main message to consumers is to choose Salmonella-free eggs (those that some official entity or producer guarantees that does not contain Salmonella), when available, especially for dishes that are not fully heat treated. Second, as guaranteed Salmonella-free eggs are only available in a few countries, refrigerated storage from the point of collection and proper cooking will significantly reduce the risk of salmonellosis. This will require a revision of the actual recommendations/regulations, as not all ensure that eggs are maintained at temperatures that prevent growth of Salmonella from collection until the time of purchasing.