Microgravity materials and life sciences research applications of digital holography

We investigate the utility of digital holographic interferometry for analyzing gravity-dependent mass transport phenomena as applicable to materials and life science research topics. Digital holography is useful for measurement of parameters that introduce phase changes in light traversing the material of interest, such as temperature or concentration variations in an aqueous environment. We have constructed, tested, and verified a compact, portable digital holographic monitor (DHM) suitable for characterization of transparent samples. It has proved useful for the study of systems such as protein crystal growth solutions and has been proposed for further application into studies involving microbial metabolism. The DHM is also sufficiently rugged for field operation in challenging environments a s may be encountered in a spacecraft or industrial setting. We discuss some system capabilities and limitations.     

Design and performance of the dilution cooler system for the Planck mission

We report the design, main features and on-ground qualification of the dilution cooler qualification model for the Planck mission. We mainly emphasize the innovative cryogenics and structural aspects developed in order to meet the severe requirements of the mission. We also report the results of the dilution cooler itself in the 100 mK range after successful tests of the qualification model on a dedicated test bench.     

Heparin-like polymers derived from dextran enhance colonic anastomosis resistance to leakage

OBJECTIVE: To determine whether a short computer interview could be used in place of a full diagnostic interview to obtain psychiatric diagnoses, the authors examined the short interview's sensitivity, specificity, and diagnostic agreement with the full interview. METHODS: Patients recently discharged from a university psychiatric service were interviewed in two back-to-back sessions, one in which a full diagnostic interview was used and the other in which a short computer interview was used. Based on diagnoses derived from both interviews, the sensitivity and specificity of the short interview and kappa values reflecting the diagnostic agreement of the two interviews were calculated. RESULTS: The short interview had high sensitivity and specificity and excellent diagnostic agreement with the full interview for most disorders. It also had a significantly shorter administration time. However, it missed a substantial percentage of cases of generalized anxiety disorder and misclassified as in remission a substantial proportion of patients with active cases of post-traumatic stress disorder. CONCLUSIONS: With few exceptions, the short interview may be substituted for the full interview when missing an active case is not important or when a count of individual symptoms and subtyping of disorders are not needed. Such uses include screening subjects for inclusion in a study and obtaining an overview of a patient's lifetime psychiatric status.     

Species-dependent enantioselective glucuronidation of carprofen

1. The stereoselective glucuronidation of carprofen, a non-steroidal anti-inflammatory drug, was investigated in vitro using microsomes prepared from liver of different species (rat, dog, horse, sheep and man) or UGT2B1 expressed in fibroblasts. 2. The Km towards the drug was very similar among these species and for the two enantiomers, whereas the Vmax varied substantially according to the animal used. The rat exhibited a high stereoselective glucuronidation whereas other species, including man, presented a low stereoselectivity. The R-enantiomer was glucuronidated at a more efficient rate than its enantiomorph, and was a better substrate (in terms of Vmax/Km). 3. To explain the enantioselective disposition of carprofen in man and in the different species, the ratio of the enzymatic efficacies (Vmax/Km) were compared with the ratio of the pharmacokinetic parameters AUCs. The basic hypothesis that the intrinsic clearance reflect the enantioselective behaviour of carprofen seemed substantiated when we focused on man and rat glucuronidation, but the in vivo-in-vitro correlation was not possible in other species. 4. In conclusion, the chiral pharmacokinetics of carprofen is less dependent on the stereoselective glucuronidation than other stereoselective processes such as protein binding of carprofen, enzymatic hydrolysis, or renal elimination of glucuronides.     

High-temperature coupling of high-speed GPC with continuous viscometry. II. Ethylene–vinyl acetate copolymers

An application of the high temperature coupling of a gel permeation chromatograph with a home-made continuous viscometric detector is described. It concerns the comprehensive characterization of ethylene–vinyl acetate copolymers. Suitable chromatographic conditions are chosen to enable a correct use of the universal calibration concept. Through analysis of poly(vinyl acetate) fractions and commercial polyethylene samples, a comparison is made with the results of classical measurements. Average molecular weights as well as intrinsic viscosity appear to be in good agreement within experimental error, which proves the system for the characterization of random ethylene–vinyl acetate copolymers. In attempting to obtain a reliable estimate of long chain branching frequency λ, a series of commercial samples has been selected, with the vinyl acetate weight fraction within the range 0–45%. As a rule, experimental viscosity law exhibits two parts, a straight line with a Mark–Houwink exponent 0.7 in the low molecular weight region and a curvature, well smoothed by a third-degree polynomial regression. Consequently, long chain branching does not appear before a limiting molecular weight of about 50,000. Beyond this limit, λ is 0.5 × 10^?4, with no dependence on molecular weight, which resembles low density polyethylene.     

Reinforcement of single-walled carbon nanotube bundles by intertube bridging

During their production, single-walled carbon nanotubes form bundles. Owing to the weak van der Waals interaction that holds them together in the bundle, the tubes can easily slide on each other, resulting in a shear modulus comparable to that of graphite. This low shear modulus is also a major obstacle in the fabrication of macroscopic fibres composed of carbon nanotubes. Here, we have introduced stable links between neighbouring carbon nanotubes within bundles, using moderate electron-beam irradiation inside a transmission electron microscope. Concurrent measurements of the mechanical properties using an atomic force microscope show a 30-fold increase of the bending modulus, due to the formation of stable crosslinks that effectively eliminate sliding between the nanotubes. Crosslinks were modelled using first-principles calculations, showing that interstitial carbon atoms formed during irradiation in addition to carboxyl groups, can independently lead to bridge formation between neighbouring nanotubes.     

Composes definis dans le systeme AgInSe structure cristalline de □2AgIn5Se8

The usual quasibinary representation obeying Parthe's laws seems too restrictive in the case of the Ag-In-Se system. According to our D.T.A. and X ray analyses, a ternary system representation has to be adopted. The crystal structure of the defect compound AgIn₅Se₈ has been refined to an agreement factor R (F) = 0.0315 in the P42m space group with unit cell parameters: $\text{a}\text{= 5.7934 (4)}\text{A}\text{?}$, $\text{c}\text{= 11.6223 (2)}\text{A}\text{?}$ and $\text{c}\text{a}\text{= 2.0061 ± 0.0003}$.     

A 65-nm Dual-Core Multithreaded Xeon® Processor With 16-MB L3 Cache

This paper describes a dual-core 64-b Xeon MP processor implemented in a 65-nm eight-metal process. The 435-mm² die has 1.328-B transistors. Each core has two threads and a unified 1-MB L2 cache. The 16-MB shared, 16-way set-associative L3 cache implements both sleep and shut-off leakage reduction modes. Long channel transistors are used to reduce subthreshold leakage in cores and uncore (all portions of the die that are outside the cores) control logic. Multiple voltage and clock domains are employed to reduce power     

Reliability and performance optimization of pipelined real-time systems

We consider pipelined real-time systems that consist of a chain of tasks executing on a distributed platform. The processing of the tasks is pipelined: each processor executes only one interval of consecutive tasks. We are interested in minimizing both the input–output latency and the period of application mapping. For dependability reasons, we are also interested in maximizing the reliability of the system. We therefore assign several processors to each interval of tasks, so as to increase the reliability of the system. Both processors and communication links are unreliable and subject to transient failures. We assume that the arrival of the failures follows a constant parameter Poisson law, and that the failures are statistically independent events. We study several variants of this multiprocessor mapping problem, with several hypotheses on the target platform (homogeneous/heterogeneous speeds and/or failure rates). We provide NP-hardness complexity results, and optimal mapping algorithms for polynomial problem instances. Efficient heuristics are presented to solve the general case, and experimental results are provided.