我国实现全面小康的电力需求

对电力需求发展的主要因素进行分析，结合能源研究所进行的我国能源发展情景的研究，评价我国电力需求预测情景的可能趋势，提出要用新的发展观看待实现全面小康的电力需求的建议。     

多晶La_(0.49)Sr_(0.51)(Mn_(1-x)Nb_x)O_3的电输运特性研究

测量了B位掺杂的钙钛矿结构锰氧化物La0 49Sr0 51(Mn1-xNbx)O3(x=0,0 05,0 15和0 25)的电阻率和磁化强度的温度特性.实验结果表明,当Nb5 部分替代B位的Mn4 离子时,电阻率-温度特性由原来单一的半导体型转变成了高温时的半导体(绝缘体)型和低温时的类金属型.随Nb掺杂量增大,电阻率迅速升高3～5个数量级,半导体(绝缘体)-类金属转变温度降低.在掺杂Nb的样品中,只观察到顺磁-铁磁转变,而未观察到铁磁-反铁磁转变.上述实验结果的一种可能解释是掺杂改变了磁有序时电子自旋的排列和空间取向,从而改变载流子被自旋热涨落的散射作用和载流子转移的随机性.     

Superior step-size theorem and its application——Parallel variable step-size LMS filters algorithm

In several branches of adaptive filtering algorithms, the least mean square (LMS) algorithm is widely applied in many areas because of its low computational cost, good numerical stability and other features[1]. However, the contradiction between faster convergence and smaller steady-state mean squared error (MSE) affects its performance considerably. Step-size, as the key to the problem, can but offer only one choice of the two demands. Therefore, many variable step-size algorithms were prop…     

基于粒子滤波和点线相合的未知环境地图构建方法

针对粒子滤波处理未知环境地图构建时存在存储空间负荷高、计算量大的问题, 本文使用线段特征描述环境信息, 将点线相合的增量式地图构建方法引入粒子滤波中. 在每个粒子中保存对已构建线段特征地图的假设; 使用点线相合的位姿估计算法将观测信息引入重要性函数, 确定采样空间; 通过观测信息与已构建线段特征地图之间的相合关系更新粒子权重; 最后通过选择性重采样去除因匹配不当和误差积累产生的错误地图. 分析表明, 该算法的复杂度较低. 在真实传感器数据上的实验结果验证了该算法构建室内环境地图的有效性和鲁棒性. 算法所需存储空间和粒子数远小于现有粒子滤波地图构建方法.     

A computational trust model for access control in P2P

Trust brings a new method for building scalable and fine-grained access control mechanism in P2P systems. The quantificational expression of trust and the calculation of trust in a trust network are the basis of trust degree based access control. In this paper, the properties of trust is analyzed by referring to the fruits from social science; the semantics of trust in the context of access control is described, and a trust degree based access control model named TDBAC is introduced. Basing on the propertie...     

基于小波的图像水印研究进展

随着多媒体和Internet的迅速发展,对数字产品保护和信息安全的迫切需求使得数字水印技术成为多媒体信息安全研究领域的一个热点问题。基于小波的多媒体水印算法近年来受到人们高度重视,特别是,随着JPEG2000将小波交换纳入其中,该领域的研究更加具有实际意义。本文首先分析了有益于图像水印的小波转换的性能,随后对基于小波的图像水印技术进行了综述,对目前常用的水印技术进行了分类和讨论,最后对小波领域图像水印的发展方向进行了展望。     

Cardiac Toxicity Associated with Immune Checkpoint Inhibitors: A Systematic Review

Immune checkpoint inhibitors (ICIs) are an important advancement in the field of cancer treatment, significantly improving the survival of patients with a series of advanced malignancies, like melanoma, non-small cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), renal cell carcinoma (RCC), and Hodgkin lymphoma. ICIs act upon T lymphocytes and antigen-presenting cells, targeting programmed cell death protein 1 (PD1), programmed cell death protein ligand 1 (PD-L1), and cytotoxic T-lymphocyte antigen 4 (CTLA-4), breaking the immune tolerance of the T cells against malignant cells and enhancing the body’s own immune response. A variety of cardiac-adverse effects are associated with ICI-based treatment, including pericarditis, arrhythmias, cardiomyopathy, and acute coronary syndrome, with myocarditis being the most studied due to its often-unexpected onset and severity. Overall, Myocarditis is rare but presents an immune-related adverse event (irAE) that has a high fatality rate. Considering the rising number of oncological patients treated with ICIs and the severity of their potential adverse effects, a good understanding and continuous investigation of cardiac irAEs is of the utmost importance. This systematic review aimed to revise recent publications (between 2016–2022) on ICI-induced cardiac toxicities and highlight the therapeutical approach and evolution in the selected cases.     

Circulating Small EVs miRNAs as Predictors of Pathological Response to Neo-Adjuvant Therapy in Breast Cancer Patients

Neo-adjuvant therapy (NAT) is increasingly used in the clinic for the treatment of breast cancer (BC). Pathological response to NAT has been associated with improved patients’ survival; however, the current techniques employed for assessing the tumor response have significant limitations. Small EVs (sEVs)-encapsulated miRNAs have emerged as promising new biomarkers for diagnosis and prediction. Therefore, our study aims to explore the predictive value of these miRNAs for the pathological response to NAT in BC. By employing bioinformatic tools, we selected a set of miRNAs and evaluated their expression in plasma sEVs and BC biopsies. Twelve miRNAs were identified in sEVs, of which, miR-21-5p, 221-3p, 146a-5p and 26a-5p were significantly associated with the Miller–Payne (MP) pathological response to NAT. Moreover, miR-21-5p, 146a-5p, 26a-5p and miR-24-3p were independent as predictors of MP response to NAT. However, the expression of these miRNAs showed no correlation between sEVs and tissue samples, indicating that the mechanisms of miRNA sorting into sEVs still needs to be elucidated. Functional analysis of miRNA target genes and drug interactions revealed that candidate miRNAs and their targets, can be regulated by different NAT regimens. This evidence supports their role in governing the patients’ therapy response and highlights their potential use as prediction biomarkers.     

A low-noise fully-differential CMOS preamplifier for neural recording applications

A fully-differential bandpass CMOS preamplifier for extracellular neural recording is presented in this paper.The capacitive-coupled and capacitive-feedback topology is adopted.We describe the main noise sources of the proposed preamplifier and discuss the methods for achieving the lowest input-referred noise.The preamplifier has a midband gain of 43 dB and a DC gain of 0.The-3 dB upper cut-off frequency of the preamplifier is 6.8 kHz.The lower cut-off frequency can be adjusted for amplifying the field or action potentials located in different bands.It has an input-referred noise of 3.36 μVrms integrated from 1 Hz to 6.8 kHz for recording the local field potentials(LFPs)and the mixed neural spikes with a power dissipation of 24.75 μW from 3.3 V supply.When the passband is configured as 100 Hz-6.8 kHz for only recording spikes,the noise is measured to be 3.01 μVrms.The 0.115 mm2 prototype chip is designed and fabricated in 0.35-μm N-well CMOS(complementary metal oxide semiconductor)2P4M process.     

基于实时拓扑属性的虚拟网络映射算法（英文）

研究目的:基于虚拟网络请求和底层物理网络实时拓扑属性,提出一种高效的两步式虚拟网络映射算法。创新要点:分别利用中介中心性和物理节点相关性对虚拟网络请求和底层物理网络中节点进行重要性评估,在此基础上给出一种两步式映射算法(算法1,2)。研究方法:首先给出中间中心性、接近中心性以及节点相关性计算模型,结合节点本地资源分别提出虚拟网络请求和物理网络中节点排名计算方式。当虚拟网络请求到达后,根据虚拟节点排名,将其映射到拥有足够资源的物理节点中排名最靠前的节点。节点映射完成后,使用K-th最短路径算法进行链路映射。映射过程中采用文献(Yu et al.,2008)中所使用的时间窗口模式进行接入控制。重要结论:利用节点本地资源,针对性分析虚拟网络请求和物理网络实时拓扑属性,提出两步式映射算法。该算法提高请求接受率、开销收益比的同时减少算法映射时间,取得更好的映射效果(图3-10)。