绿脓杆菌败血症43例临床分析

本文报道绿脓杆菌败血症43例,均经血培养证实,35例的致病菌为单菌种绿脓杆菌,余8例为复数菌,其中绿脓杆菌与葡萄球菌3例;绿脓杆菌与肺炎杆菌2例;绿脓杆菌与变形杆菌、肺炎杆菌和变形杆菌、表皮葡萄球菌和类酵母菌各1例。院内感染34例(79％)。起病均急骤,伴畏寒、发热,严重者有休克、神态改变、颅内出血、弥漫性血管内凝血、下颌弥漫性蜂窝组织炎、肺迁徙性病灶、多脏器功能衰竭,病情凶险。病死率高达83.7％。     

大肠杆菌菌种空间变异的研究

为研究微生物菌种在空间条件下产生的变异，在利用我国发射的返回式卫星上，搭载了适用于突变研究的大肠杆菌菌株ＣＳＨ１０８、Ａ３和Ａ２，使用了三种搭载方式。     

An unusual case of palmoplantar keratoderma

A 55-year-old woman with palmoplantar keratoderma presented an associated hyperhidrosis with distinct odour and maceration. She had had the lesions for about 20 years and this seemed to be an isolated case in her family. This case appeared very unusual because there were no signs of acanthokeratolysis in the biopsies. Two months of treatment with acitretin (Neotigason; 25 mg daily), produced a spectacular result: clearance of all the lesions on both hands and a strong diminution of the lesions on the soles. The Unna-Thost variant of palmoplantar keratoderma usually appears in the first few months of life, and it rarely appears in the third decade. The condition is inherited as an autosomal dominant with high penetrance and expressivity. Our subject appeared to be an exception to these two facts.     

出血性脑梗死危险因素的Logistic回归分析

目的 探讨出血性脑梗死的危险因素。方法 根据专业知识确定与出血性脑梗死有关的因素，采用非条件Logistic回归确定危险因素。结果 大面积梗死灶、使用抗凝剂或溶栓治疗、糖尿病史是出血性脑梗死的独立危险因素，与年龄、高血压史、高血脂关系不大。结论 大面积脑梗死、使用抗凝剂或溶栓、糖尿病患者发生梗死后出血的几率增大，及时行影像学检查可以早期发现。     

乳腺癌组织内雌激素受体新检测试剂的合成

1979年李善恒发明了雌激素受体检测试剂并在临床应用。为了寻找更有效、稳定、易得的受体检测试剂,我们曾以合成高分子化合物聚乙二醇代替原试剂中的牛血清白蛋白,以克服天然高分子化合物的不稳定性:另一方面,我们从雌激素的活性和改进合成路线着手,希望制备简便易得有效的试剂。     

脊柱侧弯对肺功能的影响及其手术前后对比观察

通过对１３４例脊柱侧弯患者术前肺功能检查及３２例随访患者术后肺功能检查资料分析对比结果表明：脊柱侧弯角度越大对肺功能的损害越大，先天性脊柱侧弯比特发性脊柱侧弯对肺功能的损害更大，胸段侧弯、胸腰段侧弯、腰段侧弯３组不同节段的脊柱侧弯对肺功能的影响无显著性差异。脊柱侧弯矫形术后患者肺功能得到部分改善。