全文获取类型
收费全文 | 4843篇 |
免费 | 236篇 |
国内免费 | 9篇 |
学科分类
医药卫生 | 5088篇 |
出版年
2023年 | 26篇 |
2022年 | 92篇 |
2021年 | 138篇 |
2020年 | 75篇 |
2019年 | 101篇 |
2018年 | 116篇 |
2017年 | 84篇 |
2016年 | 119篇 |
2015年 | 127篇 |
2014年 | 211篇 |
2013年 | 239篇 |
2012年 | 366篇 |
2011年 | 384篇 |
2010年 | 201篇 |
2009年 | 177篇 |
2008年 | 283篇 |
2007年 | 275篇 |
2006年 | 227篇 |
2005年 | 218篇 |
2004年 | 181篇 |
2003年 | 165篇 |
2002年 | 167篇 |
2001年 | 113篇 |
2000年 | 100篇 |
1999年 | 88篇 |
1998年 | 36篇 |
1997年 | 40篇 |
1996年 | 23篇 |
1995年 | 21篇 |
1994年 | 14篇 |
1993年 | 17篇 |
1992年 | 68篇 |
1991年 | 56篇 |
1990年 | 58篇 |
1989年 | 52篇 |
1988年 | 47篇 |
1987年 | 42篇 |
1986年 | 55篇 |
1985年 | 38篇 |
1984年 | 27篇 |
1983年 | 22篇 |
1981年 | 13篇 |
1979年 | 16篇 |
1977年 | 16篇 |
1976年 | 11篇 |
1974年 | 17篇 |
1973年 | 19篇 |
1972年 | 15篇 |
1970年 | 9篇 |
1969年 | 10篇 |
排序方式: 共有5088条查询结果,搜索用时 46 毫秒
991.
Neutral lipid storage disease is a nonlysosomal multisystemic triglyceride storage disease. It is characterized by leukocyte vacuolization (Jordans' anomaly), variable systemic involvement, and ichthyosis. Two of our patients presented with congenital ichthyosis. Lipid vacuoles were demonstrated in granulocytes and monocytes and in basal keratinocytes on skin biopsy. They were diagnosed as Chanarin Dorfman syndrome. In contrast to these cases, the third case presented with progressive symmetric erythrokeratoderma without ichthyosis. Lipid vacuoles were demonstrated in blood cells on peripheral smear and in basal keratinocytes. Only screening of peripheral smear led to the correct diagnosis. 相似文献
992.
Mave V Kulkarni V Bharadwaj R Khandekar M Gupta A Gupte N 《The National medical journal of India》2012,25(1):33-34
The reference interval is the most widely used medical decision-making tool that separates healthy from diseased individuals. We briefly discuss the methods used to determine reference interval and its limitations. 相似文献
993.
994.
995.
996.
Arvindkumar E. Ghule MPharm Chetan P. Kulkarni MPharm Subhash L. Bodhankar PhD Vijaya A. Pandit MD 《Current therapeutic research》2009,70(6):460-471
Background: Coenzyme Q10 (CoQ10) is a lipid-soluble, vitamin-like substance found in the hydrophobic interior of the phospholipid bilayer of most cellular membranes. It appears to be involved in the coordinated regulation between oxidative stress and antioxidant capacity of heart tissue when the heart is subjected to oxidative stress in various pathogenic conditions.Objective: The objective of the present study was to investigate the effect of pretreatment with CoQ10 (100 mg/kg) on isoproterenol (ISO)-induced cardiotoxicity and cardiac hypertrophy in rats.Methods: Albino male Wistar rats (250–300 g) were evenly divided by lottery method into 1 of the following 3 groups: the ISO group (olive oil 2 mL/kg orally for 18 days and ISO 1 mg/kg IP from days 9–18); the CoQ10 + ISO group (CoQ10 100 mg/kg orally for 18 days and ISO 1 mg/kg IP from days 9–18); and the control group (olive oil 2 mL/kg orally for 18 days and water IP from days 9–18). Twenty-four hours after the last dose of water or ISO, the rats were anesthetized and an ECG was recorded. Blood was withdrawn by retro-orbital puncture for estimation of serum creatine kinase-MB (CK-MB) isoenzyme levels, lactate dehydrogenase (LDH) levels, and aspartate aminotransferase activities. The animals were euthanized using an overdose of ether. The hearts of 6 animals from each group were used for estimation of superoxide dismutase (SOD) activity, reduced glutathione (GSH) concentration, lipid peroxidation (LPO), malondialdehyde (MDA), and total protein concentration. Histopathology of the 2 remaining hearts in each group was carried out by a blinded technician.Results: A total of 24 rats (8 in each group) were used in this study; all rats survived to study end. Compared with the control group, the ISO-treated rats had a significant change in heart to body weight ratio (P < 0.001); significant changes in the endogenous antioxidants (ie, significantly higher myocardial MDA concentration [P < 0.001]; significantly lower myocardial GSH concentration [P < 0.001] and SOD activity [P < 0.01]); and significantly higher serum activities of marker enzymes (eg, CK-MB [P < 0.001] and LDH [P < 0.001]). Compared with the ISO group, the CoQ10 + ISO group had a significant change in heart to body weight ratio (P < 0.001); significant changes in the endogenous antioxidants (ie, significantly lower MDA concentration [P < 0.05]; significantly higher myocardial GSH concentration [P < 0.001] and SOD activity [P < 0.05]); and significantly lower serum activities of marker enzymes (eg, CK-MB [P < 0.05] and LDH [P < 0.01]).Conclusion: Pretreatment with CoQ10 (100 mg/kg) for 18 days was associated with moderate protection against ISO-induced cardiotoxicity and cardiac hypertrophy, and with lower myocardial injury by preserving endogenous antioxidants and reducing LPO in rat heart. 相似文献
997.
998.
Kishor Taori MBBS MD Kedar G. Sharbidre MBBS Sneha Bopche MBBS Bipin Kulkarni MBBS Vijay Krishnan MBBS Amit Disawal MD 《Journal of clinical ultrasound : JCU》2009,37(8):475-477
Partial mole is a form of gestational trophoblastic disease that may be associated with serious medical complications and occasionally progresses to the second trimester of pregnancy. We present a case report of a partial mole diagnosed at 18 weeks of gestation in a septate uterus with molar placenta in one horn and a dead fetus in the other. © 2009 Wiley Periodicals, Inc. J Clin Ultrasound, 2009 相似文献
999.
1000.
Improvement in survival rates of low birth-weight infants particularly in the neonatal intensive care units of India appears
to be accompanied by frequent recognition of Necrotizing enterocolitis (NEC) among early survivors. As the philosophy and
practice of advanced care for tiny infants becomes more acceptable and affordable in the country, a steady increase in survival
of such infants is predictable. However there is growing concern in India that NEC could become a significant contributor
to morbidity and mortality in the future. NEC is currently regarded as the most common acquired gastrointestinal emergency
in the newborn period, and the outcome of this disease is universally poor. Improved understanding of the pathophysiology
and pathogenesis of this condition is required for formulating optimal principles of prevention and management. 相似文献