某市2008-2011年太湖水源生活饮用水水质监测分析及评价

目的分析2008-2011年某市太湖水源生活饮用水水质状况及变化趋势,为保障和改善居民饮用水卫生安全和卫生质量提供科学依据。方法依据《生活饮用水卫生标准》(GB 5749-2006)对2008-2011年某市太湖水源生活饮用水监测结果分析及评价。结果检测水样1 432份,合格1 331份,总合格率92.9%;年度合格率由2008年的80.5%提高到2011年的97.1%,差异有统计学意义(χ2=40.078,P0.001);不合格指标中,菌落总数、浑浊度和铁超标项次数最多,为主要不安全水质指标;对不同季节菌落总数超标率比较,差异有统计学意义(χ2=10.215,P0.017),其中第三季度最高(5.3%)。结论目前该市太湖水源生活饮用水水质基本符合GB 5749-2006的要求,少数管网水质存在微生物污染等安全隐患,今后工作中必须加强管网末梢水质的卫生监督管理。     

以全血细胞减少为首发表现艾滋病26例临床分析

目的：探讨以全血细胞减少为首发表现艾滋病患者的血液学改变、T 细胞亚群情况和预后。方法：2002年1月-2012年12月我院收治26例以全血细胞减少为首发表现的AIDS患者的临床资料进行回顾性分析。结果：全血细胞减少组患者与CD4 T淋巴细胞计数正常组比较（P＜0．05）,差异有统计学意义;AIDS患者CD4 T淋巴细胞计数的减少与淋巴细胞总数的减少存在正相关性（r＝0．462,P＜0．05）。结论：全血细胞减少患者CD4 T淋巴细胞计数明显减少;可借助淋巴细胞总数判断病程进展,协助治疗。     

内镜黏膜下剥离术治疗早期胃癌或胃癌前病变临床效果及并发出血影响因素分析

目的 探讨内镜黏膜下剥离术治疗早期胃癌或胃癌前病变临床效果,并对其并发出血影响因素进行分析.方法 回顾性分析行内镜黏膜下剥离术治疗确诊30例早期胃癌及66例胃癌前病变的临床资料,收集所有患者一般资料,观察治疗后临床效果,记录并发症、复发及生存情况,并采用单因素及多因素Lo-gistic回归分析对内镜黏膜下剥离术治疗早期...     

体外丹酚酸B改善四环素致脂肪肝的作用及机制初探

目的 建立四环素诱导HepG2细胞药物性脂肪肝模型,研究丹酚酸R对此模型的作用,并初步探讨其机制.方法 采用油红O染色观察细胞内脂质积聚情况,采用GPO＆#183;PAP法三酰甘油试剂盒定量检测细胞内三酰甘油的变化及Real-time PCR检测CD36 mRNA的表达.结果 四环素处理后能够明显增强油酸诱导的HepG2细胞脂肪变性（P＜0.05）,同时75 μmol/L四环素处理后显著提高CD36 mRNA的表达（p＜0.05）.丹酚酸B能明显改善四环素油酸诱导的HepG2细胞脂肪积聚,且呈剂量依赖性（P＜0.01）;丹酚酸B高剂量组与造模组相比能显著降低CD36 mRNA的表达（p＜0.05）.结论 丹酚酸B能够改善四环素油酸诱导的HepG2细胞脂肪变性,其作用可能与抑制CD36的表达、影响脂肪酸转运有关.     

重大任务下军人压力感知在社会支持和心理健康间的中介效应

目的 探讨军人在执行重大任务中社会支持、压力感知和心理健康三者间的关系,为做好执行重大任务军人的心理服务工作提供理论和实践依据.方法 采用《领悟社会支持量表》《压力知觉量表》和《症状自评量表》(SCL?90)对428名参加重大任务军人进行问卷调查,采用SPSS22.0和AMOS21.0软件进行统计学分析.结果 428名...     

热休克蛋白70在肝细胞癌中的表达意义

肝细胞癌(HCC)起病隐匿,致死率高,提高HCC早期诊断率对延长患者生存期非常重要.热休克蛋白70(HSP70)是广泛存在于生物体内的一种多肽蛋白,具有多种重要的生物学功能,近年来,随着对HSP70的研究,发现HCC组织中存在不同程度的HSP70表达,且其表达水平与HCC的治疗和转归也有着密切关联,利用HSP70的生物学功能及在不同组织中差异性表达的特性,能否为HCC的早期诊断、鉴别诊断、治疗及转归等方面提供帮助已成为研究热点.     

宽叶缬草在抑制高胆固醇血症大鼠肾小管上皮细胞转分化中的作用

目的：探讨宽叶缬草在脂质肾损害肾小管上皮细胞转分化中的作用。方法：用含4％胆固醇和1％胆酸钠的高脂饲料饲喂大鼠建立高脂模型，观察宽叶缬草对大鼠血脂、尿蛋白和肌酐清除率的影响，以及对肾小管上皮细胞α－平滑肌肌动蛋白、波形蛋白、角蛋白表达的影响。结果：宽叶缬草有降低总胆固醇、低密度脂蛋白和尿蛋白的作用（P＜0．01），免疫组织化学法证实宽叶缬草在降脂和降尿蛋白的同时能降低肾小管上皮细胞α－平滑肌肌动蛋白、波形蛋白的表达（P＜0．01），抑制肾上管上皮细胞转分化。结论：宽叶缬草在脂质肾损害中的肾保护作用可能与在降脂基础上对肾小管上皮细胞表型转化的抑制有关。     

基于“形神一体”理论针刺治疗中风后痉挛性偏瘫的体会*

痉挛性偏瘫是中风后常见的后遗症,其发生关键在于毒邪损伤元神、残害形体,属于“形神共病”之疾病,治疗上需“形”“神”同调。吾师刘明辉医师在“形神一体”理论指导下总结了针刺治疗中风后痉挛性偏瘫的处方,即调神取背部夹脊穴（双侧1、3、5、7、9、11、13、15、17与2、4、6、8、10、12、14、16,两组穴位隔日交替使用）+头针（病灶同侧）顶颞前斜线中2/5、顶颞后斜线中2/5、顶旁2线行针刺;调形取患肢拮抗肌筋节点行小针刀,取得了良好的疗效。本文总结刘明辉医师的临床经验,以期为临床治疗中风后痉挛性偏瘫提供新思路。     

Safety and diagnostic accuracy of percutaneous CT-guided transthoracic biopsy of small lung nodules (≤20 mm) adjacent to the pericardium or great vessels

PURPOSEWe aimed to evaluate the safety and diagnostic accuracy of computed tomography (CT)-guided transthoracic biopsy of small lung nodules (≤20 mm) adjacent to the pericardium or great vessels.METHODSThis retrospective study examined the safety and diagnostic accuracy of percutaneous CT-guided biopsy for small lung nodules (≤20 mm) located within 10 mm of the pericardium or great vessels. Technical aspects and factors influencing complications were assessed, and diagnostic accuracy was calculated.RESULTSA total of 168 biopsies were performed in 168 patients. The complications were mainly pneumothorax (34.5%; 58 of 168 patients), chest tube insertion (5.3%; 9 of 168 patients), and pulmonary hemorrhage (61.3%; 103 of 168 procedures), with no patient mortality. One patient (0.6%) was admitted because of hemorrhage complications. Significant independent risk factors for pneumothorax were nodules resided in upper or middle lobes and lateral patient position, and for hemorrhage, longer distance from structures and longer needle trajectory through the lung parenchyma. Overall, the sensitivity, accuracy, and specificity were 91.0%, 92.2%, and 100%, respectively.CONCLUSIONPercutaneous CT-guided transthoracic biopsy was highly accurate in small lung nodules (≤20 mm) adjacent to the pericardium or great vessels. Complications are common, but most were minor and self-limited.

In recent years, with wide availability of computed tomography (CT) and the development of low-dose CT screening techniques, more small lung nodules (≤20 mm) have been detected (1–3). Lee et al. (4) reported that small lung nodules were detected at a rate of 44.5%, and that 39.7% of lung cancers were found in small nodules. Accurate histopathological diagnosis is of great importance in management of these nodules, but biopsy via fluoroscopy or ultrasound guidance is technically more difficult, and CT guidance is usually required (5).Percutaneous CT-guided transthoracic lung biopsy is a reasonably safe and accurate approach to the histological diagnosis of primary and secondary lung nodules (4, 6, 7). However, nodule size is the major determinant of diagnostic accuracy, which reached 96.9% for larger nodules (7), but ranged from 52% to 78.8% for small nodules (8, 9).Biopsy of small lung nodules close to proximity to the pericardium or great vessels is particularly challenging, and precise needle placement is essential to avoid complications resulting from non-target tissue injury near vital mediastinal or vascular structures. Hsu et al. (10) suggested that CT-guided lung biopsy should be avoided if the adjacent nodule is within 10 mm of the pericardium.The authors know of no related studies of biopsy of small lung nodules close to the pericardium or great vessels. This study, therefore, was conducted to examine the safety and diagnostic accuracy of CT-guided transthoracic biopsy of small lung nodules (≤20 mm) within 10 mm of the pericardium or great vessels.     

DNA repair gene XRCC3 Thr241Met polymorphism and hepatocellular carcinoma risk

The DNA repair genes have been indicated as candidates in the risk of hepatocellular carcinoma (HCC). Published data on the association between X-ray repair cross-complementing group 3 (XRCC3), a critical member of the DNA repair genes, and HCC risk were contradictory. The aim of this meta-analysis was to assess the effect of XRCC3 Thr241Met polymorphism on HCC risk by pooling available data from published case–control studies. We calculated the pooled odds ratio (OR) with the corresponding 95 % confidence interval (95 % CI) to estimate the effect. Based on the inclusion criteria, six individual studies with 2,288 cases and 3,170 controls were included into our study. Overall, significant association between the XRCC3 Thr241Met variant and HCC risk was observed under the following contrast models (OR_{Met vs. Thr}?=?1.68, 95 %CI 1.08–2.62; OR_{MetMet vs. ThrThr}?=?5.54, 95 %CI 3.09–9.94; OR_{MetMet vs. ThrThr?+?ThrMet}?=?5.70, 95 % CI 4.24–7.64). Besides, the pooled ORs indicated that the XRCC3 Thr241Met polymorphism exerted risk effect on the HCC pathogenesis among Asians. Additionally, when stratifying by the status of smoking and hepatitis B virus infection, the XRCC3 Thr241Met variant was significantly associated with HCC risk among the HBsAg (+) individuals but not the HBsAg (?) individuals, smokers, and non-smokers. The present meta-analysis suggests that the XRCC3 Thr241Met polymorphism is an independent risk factor for HCC, particularly among Asians and the HBsAg (+) individuals.