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Mary C Tierney W Gary Snow Jocelyn Charles Rahim Moineddin Alex Kiss 《The American journal of geriatric psychiatry》2007,15(2):140-148
OBJECTIVE: The authors examined the accuracy of certain neuropsychological tests in the prediction of harm resulting from self-neglect in cognitively impaired seniors who lived alone. METHODS: The study included 130 participants, aged 65 and older, who scored less than 131 on the Dementia Rating Scale. Neuropsychological tests were administered at baseline, resulting in eight predictive scores. Informants and primary care physicians provided information about harm that occurred to the participants during the 18-month prospective follow up. An incident was defined as harmful if it occurred as the result of self-neglect or disorientation and resulted in physical injury or property loss or damage and required emergency interventions. Proportional hazard regression analysis was conducted to examine the predictive relationship between the eight neuropsychological tests and time to incident harm with age, sex, education, the Charlson Comorbidity Index, and the Mini-Mental State Examination included in the model as covariates. RESULTS: Twenty-seven participants experienced harm during the 18-month follow-up period. A proportional hazards model indicated that three neuropsychological tests, which measured recognition memory, executive functioning, and conceptualization, were independent risk factors for harm. CONCLUSIONS: These findings provide insight into why harm occurred in these cognitively impaired elders who lived alone. They also support the ecologic validity of these tests and suggest directions for the development of intervention strategies for harm prevention. 相似文献
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Mary Locniskar PhD Kathleen M. Nauss PhD Paul M. Newberne DVM PhD 《Digestive diseases and sciences》1987,32(7):747-752
Twoin vitro models of immune surveillance were used to examine the immune status of the gut-associated lymphoid tissue, mesenteric lymph nodes, and spleen during the early stages of 1,2-dimethylhydrazine (DMN)-induced colon tumorigenesis. DMH-and vehicletreated Fischer rats were sacrificed at one of three time points; one week, two months, or five months after cessation of treatment. Colonic, lymph node, and splenic natural killer cell cytolytic activity toward YAC-1 tumor targets and T-cell response to autologous la-induced balstogenesis were measured at each time point. We found little change in natural killer cell activity or T-cell proliferation induced by autologous Ia gene products at these time periods.This investigation was supported in part by grant CA26917 from the National Cancer Institute, Department of Health and Human Services. 相似文献
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Stent fracture: an unusual cause of late restenosis after sirolimus-eluting stent placement. 总被引:1,自引:0,他引:1
Anderson Mehrle Thomas Skelton Alexandra Almonacid 《Catheterization and cardiovascular interventions》2007,69(7):988-991
Stent fracture is uncommon but may have consequences including restenosis. To date, stent fractures reported have been related to aggressive post dilation. We describe a case that involves fracture of a stent deployed to nominal pressure. Unlike most stent fractures reported that involve stent struts only our case demonstrated circumferential disruption with complete separation of the stent segments. 相似文献
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Aisling Mary McMahon Fardod O'Kelly Kheng Tian Lim Narayanasamy Ravi John Vincent Reynolds 《Patient safety in surgery》2009,3(1):19
Esophageal perforation is associated with a significant risk of morbidity and mortality. We report herein a case of lye-induced
esophageal perforation managed successfully by employing endoscopic T-tube placement with a successful outcome. 相似文献