全文获取类型
收费全文 | 1800824篇 |
免费 | 129298篇 |
国内免费 | 4841篇 |
学科分类
医药卫生 | 1934963篇 |
出版年
2021年 | 16890篇 |
2019年 | 16169篇 |
2018年 | 23122篇 |
2017年 | 17720篇 |
2016年 | 20073篇 |
2015年 | 23901篇 |
2014年 | 31966篇 |
2013年 | 44606篇 |
2012年 | 62719篇 |
2011年 | 64951篇 |
2010年 | 38276篇 |
2009年 | 35413篇 |
2008年 | 58057篇 |
2007年 | 60992篇 |
2006年 | 60809篇 |
2005年 | 57747篇 |
2004年 | 55233篇 |
2003年 | 52006篇 |
2002年 | 49692篇 |
2001年 | 92880篇 |
2000年 | 94517篇 |
1999年 | 77857篇 |
1998年 | 20366篇 |
1997年 | 17738篇 |
1996年 | 17754篇 |
1995年 | 17061篇 |
1994年 | 15549篇 |
1993年 | 14267篇 |
1992年 | 57738篇 |
1991年 | 55620篇 |
1990年 | 53299篇 |
1989年 | 51028篇 |
1988年 | 46383篇 |
1987年 | 45179篇 |
1986年 | 42397篇 |
1985年 | 40175篇 |
1984年 | 29497篇 |
1983年 | 25019篇 |
1982年 | 13982篇 |
1979年 | 25658篇 |
1978年 | 17680篇 |
1977年 | 14975篇 |
1976年 | 13945篇 |
1975年 | 14626篇 |
1974年 | 17701篇 |
1973年 | 16997篇 |
1972年 | 15727篇 |
1971年 | 14500篇 |
1970年 | 13459篇 |
1969年 | 12544篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
I. Fouzas C. Papanikolaou G. Katsanos N. Antoniadis N. Salveridis K. Karakasi S. Vasileiadou A. Fouza E. Mouloudi G. Imvrios V. Papanikolaou 《Transplantation proceedings》2019,51(2):416-420
Aims
Variations of the anatomy of donor hepatic arteries increase the number of arterial anastomoses during liver transplantation and, possibly, the incidence of hepatic artery thrombosis (HAT). In this study, we describe the arterial anatomic variations in liver grafts procured and transplanted by a single center in Greece, the techniques of arterial anastomosis, and their effect on the incidence of early HAT.Materials and Methods
From January 2013 to December 2017, the arterial anatomy of 116 grafts procured for liver transplantation were recorded, as well as the technique of arterial anastomosis and the incidence of early hepatic artery thrombosis (HAT <30 days).Results
A single hepatic artery was recorded in 72.41% of the procured grafts, an aberrant left hepatic artery (accessory or replaced) in 18 grafts (15.52%), and an aberrant right hepatic artery (accessory or replaced) in 17 grafts (14.66%), while other variations were observed in less than 1% of the procured livers. Of the 116 primary liver transplantations, 6 patients (5.17%) developed early HAT <30 days. Two of these patients (1.72%) had 1 anastomosis of the hepatic artery and 4 (3.45%) had 2 anastomoses due to anatomic variations.Conclusions
Anatomic variations of the hepatic artery in liver grafts is a common finding and increase the incidence of early HAT but not to a degree to make these grafts unusable. 相似文献82.
The cingulum, connecting the orbitofrontal cortex to the medial temporal lobe, involves in diverse cognition functions including attention, memory, and motivation. To investigate the relationship between the cingulum injury and cognitive impairment in patients with chronic mild traumatic brain injury, we evaluated the integrity between the anterior cingulum and the basal forebrain using diffusion tensor tractography in 73 patients with chronic mild traumatic brain injury(39 males, 34 females, age 43.29 ± 11.42 years) and40 healthy controls(22 males, 18 females, age 40.11 ± 16.81 years). The patients were divided into three subgroups based on the integrity between the anterior cingulum and the basal forebrain on diffusion tensor tractography: subgroup A(n = 19 patients)-both sides of the anterior cingulum were intact; subgroup B(n= 36 patients)-either side of the anterior cingulum was intact; and subgroup C(18 patients)-both sides of the anterior cingulum were discontinued. There were significant differences in total Memory Assessment Scale score between subgroups A and B and between subgroups A and C. There were no significant differences in diffusion tensor tractography parameters(fractional anisotropy, apparent diffusion coefficient, and fiber volume) between patients and controls. These findings suggest that the integrity between the anterior cingulum and the basal forebrain, but not diffusion tensor tractography parameter, can be used to predict the cognitive function of patients with chronic mild traumatic brain injury. This study was approved by Yeungnam University Hospital Institutional Review Board(approval No. YUMC-2014-01-425-010) on August 16, 2017. 相似文献
83.
Lara Feulner Hamed S. Najafabadi Simon Tanguay Janusz Rak Yasser Riazalhosseini 《Urologic oncology》2019,37(2):166-175
Background
Clear cell renal cell carcinoma (ccRCC) is known to occur across the adult lifetime traversing the spectrum of age-related organismal changes. Little is known as to how the aging process may affect the course of renal cell carcinoma (RCC) and the repertoire of genes involved.Methods
Using The Cancer Genome Atlas (n?=?436) and Cancer Genomics of the Kidney (n?=?89) datasets, we applied regression analysis to examine associations between patient age and gene expression profiles in ccRCC tumors and normal kidney tissues. Pathway enrichment analysis was performed to identify cellular process that is affected by aging in ccRCC. Moreover, connectivity mapping analysis was used to predict age-dependent response to drug treatments.Results
Our analysis revealed different age-dependent gene expression spectra in ccRCC and normal kidney tissues. These findings were significant and independently reproducible in both datasets examined. Age up-regulated genes, showing higher expression in older patients, were significantly enriched (false discovery rate <0.05) in normal tissues for pathways associated with immune response and extracellular matrix organization, whereas age up-regulated genes in tumors were enriched for metabolism and oxidation pathways. Strikingly, age down-regulated genes in normal cells were also enriched for metabolism and oxidation, while those in tumors were enriched for extracellular matrix organization. Further in silico analysis of potential drug targets predicted preferential efficacy of Phosphoinositide 3-kinase inhibitor or immunotherapy in association with age.Conclusion
We report on previously unrecognized associations between age and molecular underpinnings of RCC, including age-associated expression of genes implicated in RCC development or treatment. 相似文献84.
Renal Denervation for Treatment of Cardiac Arrhythmias: State of the Art and Future Directions 下载免费PDF全文
JEDRZEJ KOSIUK M.D. SEBASTIAN HILBERT M.D. EVGENY POKUSHALOV M.D. GERHARD HINDRICKS M.D. Ph.D. JONATHAN S. STEINBERG M.D. ANDREAS BOLLMANN M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2015,26(2):233-238
Renal Denervation for Treatment of Cardiac Arrhythmias . It has now been more than a quarter of a century since modulation of the sympathetic nervous system was proposed for the treatment of cardiac arrhythmias of different origins. But it has also been some time since some of the early surgical attempts have been abandoned. With the development of ablation techniques, however, new approaches and targets have been recently introduced that have revolutionized our way of thinking about sympathetic modulation. Renal nerve ablation technology is now being successfully used for the treatment of resistant hypertension, but the indication spectrum might broaden and new therapeutic options might arise in the near future. This review focuses on the possible impact of renal sympathetic system modulation on cardiac arrhythmias, the current evidence supporting this approach, and the ongoing trials of this method in electrophysiological laboratories. We will discuss the potential roles that sympathetic modulation may play in the future. 相似文献
85.
86.
87.
88.
Interaction effects between the 5‐hydroxy tryptamine transporter‐linked polymorphic region (5‐HTTLPR) genotype and family conflict on adolescent alcohol use and misuse 下载免费PDF全文
89.
90.