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741.
742.
KEIKO MATSUBAYASHI HIROSHI MATSUMOTO YUKO FUKUI 《The Journal of pharmacy and pharmacology》1997,49(5):551-557
The contribution of the cytochrome P450 3A pathway to bromocriptine metabolism, and the effects of ferrous iron and hypoxia-re-oxygenation on its elimination, were evaluated with the perfused rat liver. Outflow profiles of bromocriptine after bolus administration were estimated by moment analysis and dispersion model analysis. Kinetic parameters were not significantly changed by troleandomycin, a P450 3A inhibitor. The inhibition of bromocriptine metabolism by troleandomycin was 5.7 ± 2.4%. These findings indicate that cytochrome P450 3A does not play an important role in bromocriptine elimination with the perfused rat liver. Elimination rate constant (ke) values were significantly increased by ferrous iron perfusion or hypoxia-re-oxygenation. Free-radical generation can, therefore, affect bromocriptine elimination. Our observations suggest that bromocriptine might be eliminated by scavenging of free radicals in the liver. 相似文献
743.
NEUROCHEMICAL CHARACTERISTICS AND BEHAVIORAL RESPONSES TO PSYCHOLOGICAL STRESS IN OVARIECTOMIZED RATS 总被引:1,自引:0,他引:1
JUN ZHANG MASATO INAZU KAORI TSUJI ETSURO YAMADA HIROSHI TAKEDA TERUHIKO MATSUMIYA 《Pharmacological research》1999,39(6):455-461
The present study was designed to clarify the time-dependent changes in brain monoamine turnover in the frontal cortex, hypothalamus, hippocampus, septum and amygdala after ovariectomy, and the difference in behavioral responses to psychological stress between sham-operated and ovariectomized (OVX) rats. At 2 and 4 weeks after ovariectomy, the turnover rates of dopamine and norepinephrine in all of the brain regions examined did not differ significantly between the sham-operated and OVX rats. However, 5-hydroxytryptamine (5-HT) turnover in all of the brain regions at 2 weeks after OVX was significantly lower than that in sham-operated rats. This difference was greater in the hypothalamus than in other brain regions. At 4 weeks after ovariectomy, 5-HT turnover in all of the brain regions examined was not significantly different between sham-operated and OVX rats. At 2 and 4 weeks after ovariectomy, exploratory behaviour (e.g., locomotor activity, head- dipping, crossing and rearing behaviours) in a non-stressed ovariectomy group did not differ from that in a non-stressed sham-operation group. Locomotor activity and the number of head-dips and crossings significantly (P<0.05) increased after repeated exposure to psychological stress for 5 days in sham-operated rats, but not in those at 2 weeks after OVX. At 4 weeks after ovariectomy, locomotor activity and the number of crossings and rearings in sham-operated and OVX rats were not significantly different in the psychological stress and non-stress groups. However, the number of head-dips significantly (P<0.05) increased with psychological stress in the sham-operated rats, but not in OVX rats. These results suggest that female gonadal hormones may play an important role in the regulation of brain 5-HTergic systems. These interactions between gonadal hormones and 5-HT metabolism may be related to 5-HT-related neuropsychiatric disorders. 相似文献
744.
Prospective Evaluation of Electromyography‐Guided Phrenic Nerve Monitoring During Superior Vena Cava Isolation to Anticipate Phrenic Nerve Injury 下载免费PDF全文
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Esophagus‐Related Complications During Second‐Generation Cryoballoon Ablation—Insight from Simultaneous Esophageal Temperature Monitoring from 2 Esophageal Probes 下载免费PDF全文
746.
Adenosine Triphosphate Test After Cryothermal Pulmonary Vein Isolation: Creating Contiguous Lesions Is Essential for Eliminating Dormant Conduction 下载免费PDF全文
747.
Electrocardiographic QRS Fragmentation as a Marker for Myocardial Fibrosis in Hypertrophic Cardiomyopathy 下载免费PDF全文
TETSUO KONNO M.D. Ph.D. KENSHI HAYASHI M.D. Ph.D. NOBORU FUJINO M.D. Ph.D. RIE OKA M.D. Ph.D. AKIHIRO NOMURA M.D. YOJI NAGATA M.D. AKIHIKO HODATSU M.D. KENJI SAKATA M.D. Ph.D. HIROSHI FURUSHO M.D. Ph.D. MASAYUKI TAKAMURA M.D. Ph.D. HIROYUKI NAKAMURA M.D. Ph.D. MASA‐AKI KAWASHIRI M.D. Ph.D. MASAKAZU YAMAGISHI M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2015,26(10):1081-1087
748.
Long‐Term Results of Radiofrequency Hot Balloon Ablation in Patients With Paroxysmal Atrial Fibrillation: Safety and Rhythm Outcomes 下载免费PDF全文
749.