Pain and faulty breathing: a pilot study

The purpose of this pilot study was to observe both relaxed and deep breathing patterns in a convenience sample to determine the incidence of normal versus faulty patterns of respiration. These observations were then combined with respondent answers to a survey on pain history to determine if there is any correlation between faulty breathing and musculo-skeletal pain patterns. If such a correlation can be made, then we propose that clinicians working with chronic pain patients may have improved outcomes if they address and correct faulty breathing patterns. Based on this study, it is suggested to include the evaluation and treatment of faulty respiration in the rehabilitation of chronic musculo-skeletal conditions, most notably cervical pain.     

人工髋关节置换并发假体周围骨折的临床分析

[目的]分析人工髋关节置换术中、术后发生假体周围骨折的原因，探讨其预防措施和治疗方法。[方法]自1995年7月-2006年8月，共640例人工髋关节置换术患者，其中18例发生假体周围骨折，术中骨折11例（股骨距骨折7例，假体柄下端骨折4例），术后骨折7例（假体柄下端、远端骨折），男12例，女6例，年龄51-79岁，平均68岁，按照髋关节假体置换术后骨折的AAOS分型：I型1例，Ⅱ型4例，Ⅲ型4例，IVa型4例，IVb型2例，V型1例，Ⅵ型2例，其中术中假体周围骨折11例有10例予立即内固定，1例（Ⅱ型）股骨距劈裂骨折无明显移位未做内固定，仅延迟下地负重时间；术后假体周围骨折7例有4例在两周内行手术内固定，2例合并假体松动而采用全髋关节翻修术，1例（Ⅵ型）假体远端骨折因身体原因无法手术而采取保守治疗予以骨牵引4周后改石膏外固定。[结果]术后平均随访时间15．2个月（6-38个月），15例患者骨折均达到骨性愈合，2例发生骨折延迟愈合，保守治疗的1例患者术后6个月拍x线片示骨折畸形愈合，术后8个月因内科疾病死亡。Harris评分平均80分（67-92分）。[结论]术中暴力、股骨髓腔发育异常、假体型号过大、骨质疏松是术中假体周围骨折发生的主要原因，骨溶解、假体松动、骨质疏松加外伤是术后发生假体周围骨折的主要原因，根据不同分型采用不同的治疗方法以促进骨折愈合，稳定假体，减少卧床时间和并发症（尤其对高龄患者更为重要），尽早恢复功能。     

动态心电图对起搏器间歇性感知功能异常的诊断价值

目的 :探讨动态心电图检测对起搏器间歇性感知功能异常的诊断价值。方法 :采用MarquetteMars30 0 0动态心电图仪 ,对 36例 (4 9例次 )安装起搏器的患者进行随访 ,分析起搏、感知及与起搏器相关的心律失常。结果 :共检出起搏器间歇性感知功能异常 17例 (2 4例次 ) ,检出率为 4 7.2 % ,有 5例 (7例次 )合并两项感知异常。所有感知异常除 1例在常规心电图中检出外 ,其余 16例只在动态心电图中发现。检出与起搏器相关的心律失常 12例。根据动态心电图结果进行相应临床处理后 ,部分起搏器的感知功能异常消失。结论 :起搏器的感知功能异常多为间歇性的 ,动态心电图对间歇性感知异常的检出率较高 ,应是起搏器随访不可或缺的手段。     

一种鉴别免疫筛选噬菌体克隆真、假阳性的方法

目的探讨及早鉴别用免疫学方法筛选cDNA文库得到的阳性克隆是否真实可靠的方法.方法将阳性噬菌体克隆与宿主菌按一定的比例诱导培养后,取沉淀做SDS-PAGE后行W estern b lot;同时取出一个阳性克隆进行亚克隆,直至3次亚克隆均为全部阳性.结果3次亚克隆均为全部阳性的噬菌体克隆,在W estern b lot鉴定中也呈阳性反应.结论可用W estern b lot方法来鉴别用免疫学方法筛选cDNA文库得到的阳性克隆是否真实可靠.     

Metabolic fate of valproic acid in the rhesus monkey. Formation of a toxic metabolite, 2-n-propyl-4-pentenoic acid

The metabolic fate of an iv bolus dose (13.5 mg kg-1) of valproic acid (VPA) was studied in adult male rhesus monkeys. Renal excretion proved to be the major route of elimination of the drug and a total of 17 metabolites, accounting collectively for some 82% of the administered dose, were identified in urine by GC-MS techniques. Many of these metabolites were present largely in the form of glucuronide conjugates, as was VPA itself. The principal pathways of VPA biotransformation were, in order of decreasing quantitative importance, ester glucuronide formation, omega-oxidation, beta-oxidation and (omega-1)-hydroxylation. In addition, three mono-unsaturated metabolites, identified as (E)-delta 2-, (E)-delta 3-, and delta 4-VPA, were detected in both plasma and urine. Quantitative analysis of these unsaturated VPA metabolites indicated that the delta 4 olefin, which is known to be a potent hepatotoxic agent, was the predominant isomer of the group.     

中药煎剂保留灌肠治疗慢性结肠炎85例

目的:观察中药煎剂保留灌肠治疗慢性结肠炎的临床疗效。方法:对85例慢性结肠炎患者采用中药煎剂保留灌肠,同时服用654-2片治疗,观察临床症状和乙状结肠镜下的变化。结果:轻度41例,2个疗程治愈38例,3个疗程治愈3例;中度26例,3个疗程治愈24例;重度18例,3个疗程治愈8例,4个疗程治愈8例。痊愈率95.29%,总有效率100%。结论:中药煎剂保留灌肠治疗慢性结肠炎,疗效肯定,安全可靠。