育嗣灵胶囊制剂工艺研究

目的:探讨育嗣灵胶囊的最佳制备工艺.方法:以淫羊藿苷的含量为指标,通过正交试验设计L9(34),优选育嗣灵胶囊的最佳制备工艺.结果:最优提取工艺为A2 B2 C3 D3,即加8倍量80%乙醇提取3次,每次2.0小时,淫羊藿苷浸出率最高.结论:优选得到的工艺简单,稳定,淫羊藿苷提取率高.     

HPLC测定薏仁合剂中芍药苷的含量

目的:建立薏仁合剂中芍药苷含量测定的HPLC.方法:色谱柱为Kromasil C18柱(250 mm×4.6 mm,5μm),采用乙腈-0.1％磷酸溶液(16:84)作为流动相,流速为1.0 ml/min,检测波长为230 nm.结果:芍药苷在45.4～453.5μg/ml范围内线性关系良好(r=0.9996),平均回收率为99.1％,RSD为0.68％(n=9).结论:该方法操作简便,准确,精密度高,可用于控制薏仁合剂的质量.     

添加相氧化铝对牙科纳米氧化锆陶瓷性能的影响

Objective To study the effects of alumina content on sintered density, mechanical property and translucency of zirconia nanocomposite all-ceramics. Methods Specimens of zirconia nanocomposite all-ceramics were divided into five groups based on their alumina content which are 0% (control group), 2. 5% , 5. 0% , 7. 5% and 10. 0% respectively. The sintered densities were measured using Archimedes' method. Specimens' bending strengths were measured with three-point bending test( ISO 6872). The visible light transmittances were measured with spectrophotometric arrangements and the fractured surfaces were observed using scanning electron microscope (SEM).Results The control group of pure zirconia could be sintered to the theoretical density under pressure-less sintering condition. The bending strength was (1100.27 ±54.82) MPa, the fracture toughness was (4.96 ±0.35) MPa·m1/2 and the transmittance could reach 17. 03%. The sintered density and transmittance decreased as alumina content increased from 2. 5% to 10%. However, the fracture toughness only increased slightly. In all four alumina groups, the additions of alumina had no significant effect on samples' bending strengths (P >0. 05). When the content of alumina was 10% , fracture toughness of specimens reached (6. 13 ±0.44) MPa·m1/2 while samples' transmittance declined to 6. 21 %. SEM results showed that alumina particles had no significant effect on the grain size and distribution of tetragonal zirconia polycrystals. Conclusions Additions of alumina to yttria-tetragonal zirconia polycrystals could influence its mechanical property and translucency. Additions of the other phase to zirconia ceramics should meet the clinical demands of strength and esthetics.     

冬菊利咽合剂对慢性咽炎作用的实验研究

目的探讨冬菊利咽合剂治疗慢性咽炎的作用机制,为临床治疗慢性咽炎提供依据。方法采用药理学和超微结构等方法,在小鼠和家兔不同病理模型上观察冬菊利咽合剂的抗炎作用以及对慢性咽炎的治疗作用。结果在小鼠的二甲苯致耳廓水肿模型上,冬菊利咽合剂处理组与对照组相比耳廓水肿明显减轻;在家兔慢性咽炎动物模型上,冬菊利咽合剂处理组动物咽部血管扩张瘀血、炎症细胞浸润、上皮增生和腺体分泌情况明显轻于造模组。结论冬菊利咽合剂治疗慢性咽炎的作用可能与其抑制咽部炎症病理改变的发生有关。     

浅谈医院制剂的现状及发展方向

回顾医院制剂的发展历程,简述其现状,对新形势下医院制剂面临的新情况进行分析.医院制剂正在逐步萎缩但又不可缺少,应向少而精的方向发展,要紧密结合临床需要开发医院的特色制剂,进而开发新药,从供应保障型向技术开发型转变,以便更好地配合临床工作.     

仙藿胶囊制剂工艺研究

目的:探讨仙藿胶囊的最佳制备工艺.方法:以淫羊藿苷的含量为指标,通过正交试验设计L.(3'),优选仙藿胶囊的最佳制备上艺.结果:最优提取工艺为A2B2C3D3,即加8倍量80%乙醇提取3次,每次2.0小时,淫羊藿苷浸出率最高.结论:优选得到的工艺简单,稳定,淫羊藿苷提取率高.     

复方异丙嗪甘草口服溶液的制备及临床应用

目的：研制一种儿科常用止咳化痰药复方异丙嗪甘草口服溶液,并考察临床疗效。方法：建立复方异丙嗪甘草口服溶液的制备及质量控制方法;并与急支糖浆作对照,进行临床疗效观察。结果：该制剂质量稳定,治疗组总有效率为84．2％,对照组总有效率为45．1％,治疗组疗效明显优于对照组（P〈0．05）。结论：复方异丙嗪甘草口服溶液制备方法简单,质量控制方法可靠,临床疗效满意。     

高效液相色谱法测定复方己烯雌酚乳膏中己烯雌酚和氯霉素的含量

目的用高效液相色谱法同时测定复方已烯雌酚乳膏中己烯雌酚和氯霉素的含量。方法采用Kromasil C18色谱柱（250mm×4．6mm，5μm），流动相为甲醇-水（70：30），流速为0．7mL／min，检测波长为241nm。结果己烯雌酚线性范围是7．5-17．5μg／mL。r=0．9998（n=5），平均回收率为99．95％，RSD为1．35％；氯霉素的线性范围是375-875μg／mL，r=0．9999（n=5），平均回收率为99．87％，RSD为0．58％。结论高效液相色谱法操作简便、灵敏度高．重现性好，可用于复方己烯雌酚乳膏中己烯雌酚和氯霉素的含量测定。     

HPLC测定旱莲胶囊中补骨脂素和异补骨脂素的含量

目的建立测定旱莲胶囊中补骨脂素和异补骨脂素含量的高效液相色谱方法.方法色谱柱为Termo C18柱(250mm×4.6mm,5μm),流动相为甲醇-水(50∶50),流速为0.6 ml·min-1,检测波长为295nm.结果补骨脂素的线性范围为0.2～0.6μg,r=0.9998(n=5),平均回收率为99.2%,RSD为1.01%;异补骨脂素的线性范围为0.2～0.6μg,r=0.9999(n=5),平均回收率为100.3%,RSD为2.22%.结论该方法操作简便,准确,精密度高,可用于控制旱莲胶囊的质量.