牙周韧带细胞与成体干细胞

成体干细胞是目前研究的热点，人们陆续在多种组织中找出了成体干细胞。但是牙周韧带中成体干细胞及其与牙周韧带细胞的关系，目前尚无统一认识。本文将对该方面的研究现状作一综述。     

IL—1家族与牙周炎研究的新进展

ＩＬ－１家族包括ＩＬ－１α，ＩＬ－１β和ＩＬ－１受体拮抗剂（ＩＬ－１ｒａ）。本文综述了ＩＬ－１家族各成员与牙周炎发生，发展关系的研究进展。并描述了ＩＬ－１ｒａ的临床前期动物模型研究成果，指出了ＩＬ－１ｒａ成为一种治疗牙周炎的非激素类抗炎新药有关的问题。     

中性多形核白细胞IgG Fc受体与牙周炎

中性多形核白细胞对牙周病原菌的吞噬作用在牙周炎的发病机制中起着重要作用。它的功能受其细胞膜表面IgGFc受体基因多态性的影响。本文就Fcγ受体的分子结构、功能、基因多态性、表型/基因型的检测方法及其与牙周炎的关系作一综述。     

IL－8及其在牙周病中的作用

ＩＬ－８及其在牙周病中的作用谢昊综述曹采方，马大龙审校北京医科大学口腔医学院牙周科（１０００８１）免疫学教研室中性粒细胞是存在于正常龈沟内的主要防御细胞，也是出现在早期炎性牙周病灶中的优势细胞，一些因子可促进中性粒细胞的聚集和趋化，如补体Ｃ５ａ、血小...     

透热通痹汤结合中医外治法对湿热痹阻型痛风性关节炎疗效分析

目的 :探讨透热通痹汤结合梅花针扣刺、中药贴敷对湿热痹阻型痛风性关节炎的治疗效果,并分析其临床可行性。方法 :选取2018年1月—2018年11月来我院风湿免疫科门诊就医的湿热痹阻型痛风性关节炎患者96例。按照其就诊顺序对患者进行编号,采用随机数字表法随机将患者分为治疗组48例和对照组48例。治疗组采用透热通痹汤结合梅花针扣刺、中药贴敷治疗;对照组采用秋水仙碱口服结合梅花针扣刺、中药贴敷治疗。观察两组患者治疗前后红细胞沉降率(ESR)、C-反应蛋白(CRP)、血尿酸(UA)等实验室指标的变化情况;观察治疗前后疼痛、肿胀、关节活动度评分的变化情况;比较两组患者的治疗效果;观察两组患者的安全性指标(如:血常规、尿常规、肝功能、肾功能等)。结果 :两组患者治疗前后血液指标的比较中,治疗后的ESR、CRP、UA均较治疗前明显下降,且差异有统计学意义,治疗后治疗组和对照组的比较中,C-反应蛋白下降不明显,血尿酸、红细胞沉降率变化的比较治疗组明显优于对照组,且差异有统计学意义;两组患者治疗后疼痛、肿胀及关节活动均较治疗前有明显改变,且差异有统计学意义,两组间比较治疗组明显优于对照组,且差异有统计学意义;两组患者疗效的比较中,治疗组的总有效率高于对照组,且差异有统计学意义;两组患者不良反应的比较,治疗组明显优于对照组,且差异有统计学意义。结论 :透热通痹汤结合梅花针扣刺、中药贴敷对湿热痹阻型痛风性关节炎的治疗效果显著,值得临床推广使用。     

针灸联合桂枝附子乌头汤治疗风寒湿痹型类风湿关节炎临床观察

目的探讨针灸联合桂枝附子乌头汤对风寒湿痹型类风湿关节炎的治疗效果,分析其临床可行性。方法选取2018年1月—11月收治的风寒湿痹型类风湿患者96例。按照就诊顺序对患者进行编号,采用随机数字表法随机分为治疗组和对照组各48例。治疗组采用针灸联合院内制剂桂枝附子乌头汤治疗;对照组采用院内制剂桂枝附子乌头汤治疗。对类风湿关节炎的主要症状进行量化评分,比较2组患者的治疗效果。结果 2组患者的主要症状量化评分比较,治疗组明显优于对照组; 2组患者疗效比较,治疗组效果明显优于对照组。结论针灸结合桂枝附子乌头汤对风寒湿痹型类风湿关节炎的治疗效果显著,值得临床推广使用。     

国内药物不良反应信号检测文献中数据挖掘问题的调查和分析CSCD

Objective To understand the problems of data mining in adverse drug reaction (ADR)/adverse event (AE) signal detection study in China. Methods The literature on ADR/AE signal detection study in SinoMed, CNKI, WanFang Data and VIP databases were retrieved (up to May 30, 2022). The relevant content of the data mining in the literature was investiagted and evaluated from the following 4 dimensions and 9 items: (1) background data, including 1 item; (2) data preprocessing, including 4 items such as drug mapping, AE mapping, missing value processing, and data deduplication; (3) data mining algorithm (DMA), including 3 items such as DMA selection, DMA formula interpretation, and signal threshold; (4) interpretation of the results, including 1 item. According to the relevant specifications and technical requirements of data mining, the reporting/reporting error‑free rate of the 4 dimensions and 9 items in the literature was taken as the overall quality evaluation index. Reporting/reporting error-free rate ≥60% was considered to be an excellent level of overall quality. Results A total of 165 articles were included. On the background data dimension, the reporting/reporting error‑free rate of using all the other drug data of the entire database in the literature was 35.2% (58/165), which did not reach an excellent level. On the data preprocessing dimension, the reporting/reporting error‑free rates of drug mapping, AE mapping, missing value processing, and data deduplication in the literature were 22.4% (37/165), 73.9% (122/165), 10.3% (17/165), and 55.2% (91/165), respectively. The reporting/reporting error‑free rate on this dimension was 40.5% (267/660), which did not reach the excellent level, only the rate of AE mapping reached the excel‑ lent level. On the DMA dimension, the reporting/reporting error‑free rates of ≥2 DMA, DMA formula inter‑ pretation, and signal threshold in the literature were 63.6% (105/165), 78.2% (129/165), and 87.9% (145/ 165), respectively. The reporting/reporting error‑free rate on this dimension was 76.6% (379/495), which reached an excellent level. The reporting/reporting error‑free rate was 87.4% (144/165), reaching an excel‑ lent level. The signals were interpreted as "positive" or "negative" signals in 7 articles, and the meaning of signals were interpreted as causality in 14 articles. The overall reporting/reporting error‑free rate in the 165 literature, analyzed from 9 items on 4 dimensions, was 57.1% (848/1 485), which did not reach the excellent level. Conclusion The main problems in the domestic literature of ADR/AE signal detection study are the incomplete selection of background data and the lack of data preprocessing, suggesting that the further relevant studies in China should be improved on above 2 dimensions for better quality of ADR/ AE signal detection research. © 2023 Chinese Medical Association. All rights reserved.     

牙周炎基础治疗对咬合力和牙周状况影响的观察

目的 探讨牙周基础治疗对慢性牙周炎(CP)牙周状况和最大咬合力的影响。方法 重度CP病例27例,每病例双侧磨牙各选择一患牙(初诊患牙牙周袋≥5mm,牙松动度≤Ⅱ度),随机分为龈上洁治组(S组)和根面平整组(P组)。S组患牙给予龈上洁治、碘氧液冲洗疗法;P组患牙予以龈上洁治、根面平整和碘氧液冲洗疗法。分别在治疗前和治疗后1、3、6个月测定息牙的咬合力值、龈炎指数(GI)、牙周袋深度(PD)。结果 ①P组治疗后1、3、6个月,最大咬合力值较治疗前有显著性提高(P<0.05);S组与治疗前无显著性差异(P>0.10)。②治疗后1个月,两组的咬合力值无显著性差异(P>0.05);治疗后3、6个月,P组的咬合力显著高于S组(P<0.01);③治疗后3、6个月,P组的GI值、PD值显著低于S组(P<0.001)。结论 洁治、根面平整治疗对于CP患牙的最大咬合力、GI、PD的改善是持续性的,较龈上洁治有显著性差异。     

神经血管损伤介导2型糖尿病轻度认知障碍的研究进展

2型糖尿病(T2DM)是轻度认知功能障碍(MCI)的危险因素,认知功能障碍严重影响T2DM患者的生活质量。T2DM伴MCI主要表现为多维度认知功能损伤但机制不明,微血管和神经元损伤是导致大脑认知改变的主要原因。本篇综述深入探讨了2型糖尿病引发神经元和微血管损伤的潜在机制,由此揭示出T2DM可能通过多种途径引起T2DM患者神经血管失偶联,最终导致MCI。