异常增加的α-突触核蛋白对帕金森病模型小鼠黑质及结肠多巴胺受体D1的表达影响

目的 探讨异常增加的α-突触核蛋白(α-Syn)对小鼠脑及结肠多巴胺受体D1(D1DR)表达的影响.方法 将C57BL/6J小鼠随机分为对照及模型组,纹状体立体定位注射α-Syn预成型纤维(PFF)制备小鼠帕金森病(PD)模型,对照组注射等体积PBS;术后6个月进行平衡杆、爬杆及旷场实验检测小鼠行为学差异;通过West...     

油腻食物容易引发胆心综合征

油腻食物可使胆囊收缩引发胆绞痛,但为何胆病会殃及心脏呢？原因是患上了胆心综合征。所谓胆心综合征,是由于胆系疾病（胆囊炎、胆结石症）发作,引起胆绞痛,并通过神经反射引起心绞痛——因为支配胆系的神经和支配心脏的神经在脊髓部位有部分交叉,当胆疾发作时,通过神经反射,就可引起冠状动脉收缩、痉挛,冠状动脉血流骤减,遂可出现心绞痛、心律失常,心电图也可见心肌缺血的表现。     

核素心肌灌注显像定量分析技术诊断本地人群冠心病的价值

Objective To evaluate the accuracy of automated quantification of myocardial perfusion imaging (MPI) using a method based on a Western normal database for the detection of coronary artery disease (CAD) in a group of Chinese patients. Methods Seventy-two Chinese patients who underwent coronary angiography (CAG) and MPI within 3 months were recruited into this study. Eighty selected from 140 Chinese patients with low probability of CAD ( ＜ 5% ) were enrolled into local normal database of 99Tcm-methoxyisobutylisonitrile (MIBI) MPI using Cedars quantitative perfusion SPECT (QPS) database. Two Western MPI normal databases (CSMC MibiMbiAuto and Mibimibi) were used for processing the Chinese CAD patients recruited in this study, and the results were compared with those using local normal database and visual interpretation. T-test and z-test were used for statistical analysis. Results The extent (EXT)measurement obtained from Mibimibi and local database was ( 10.73 ± 14.54)% and ( 14.22 ± 16.51 )%,respectively ( t = 7.87, P ＜ 0.001 ); the severity (SEV) was 1.07 ± 0.93 and 1.34 ± 1.20, respectively ( t =7.45, P＜0.001). The area under curve(AUC) by using EXT measurement for local database (0.85 ±0.05) was larger than that for CSMC MibiMbiAuto ( AUC = 0.72 ± 0.06, z = 2.50, P ＜ 0.01 ) and Mibimibi ( AUC = 0.77 ± 0.06, z = 2.47, P = 0.014). The AUC of local database showed no significant difference from that of visual interpretation (AUC=0.83 ±0.05, z=0.05, P＞0.05). Conclusion Quantification of MPI of our Chinese patients using Western normal database would decrease the accuracy for the detection of CAD.     

经皮冠状动脉内支架植入术对外周血单核细胞NF-κB活性的影响

目的:探讨经皮冠状动脉内支架植入术是否激活外周血单核细胞(PBMCs)中核因子κB(NF-κB)活性的表达.方法:选择NF-κB基线时呈阴性反应的稳定型心绞痛患者50例,其中单纯造影组22例,支架治疗组28例.分别于冠脉造影或支架术后4 h及术后第1,2,3 d留取全血抗凝标本;采用凝胶电泳迁移率实验(EMSA)测定PBMCs中NF-κB的活性.结果:支架术程中NF-κB活性呈动态变化,于术后1 dNF-κB活性显著性升高呈阳性反应,术后2 d NF-κB活性达峰值,术后3 d NF-κB活性有下降,但仍保持在高水平表达状态.而造影组患者则没有NF-κB活性变化.结论:冠状动脉内支架术激活外周血单核细胞NF-κB活性.     

经皮介入治疗心脏瓣膜疾病的进展

本文介绍经皮介入治疗心脏瓣膜疾病的进展,重点介绍了经皮瓣膜扩张成形术,经导管人工心脏瓣膜置换与修补术的研究与临床进展。     

特发性右室流出道室速的昼夜发作规律及临床意义

目的：探讨特发性右室流出道室速的昼夜发作规律及临床意义,方法：对12例特发性右室流出道室速患者在基础状态进行动态心电图（Holter)监测,分别记录24h中每小时内心律失常发作频数及平均心率,了解室速,室早发作的昼夜规律,结果：基础状态下,室速,连发室早,平均心率在24h内呈不均一分布（P＜0．001）,其发作规律呈白天多,夜间少,单个室呈不均一分布,但整个差异无显著性,平均心率与室速,连发室早互正相关,单个室早与平均心率无相关性,结论：左室流出道室速患者24h内室速,连发病早呈明显的昼夜节律变化,提示特发性右室流出道室速的发生与交感迷走神经平衡失调有关。     

超声心动图与左心室造影诊断心尖肥厚性心肌病比较

目的 探讨超声与左心室造影诊断心尖肥厚型心肌病(AHCM)的价值.方法 回顾分析36例经超声心动图或/和左心室造影明确诊断的AHCM病例,评价超声心动图、心室造影及冠状动脉造影在AHCM中的诊断价值.结果 心脏超声检查35例,16例诊断AHCM,诊断阳性率45.7%;左心室造影33例,25例诊断AHCM,阳性率75.7%.同时接受超声与左心室造影的患者诊断AHCM不一致性为68.6%.无一例合并冠心病.结论 超声心动图与左心室造影对诊断AHCM差别巨大,AHCM几乎不合并冠心病.左心室造影对诊断AHCM更可靠.