A new method for evaluating antiarrhythmic drug efficacy

To develop standards for distinguishing antiarrhythmic drug effect from spontaneous variability of premature ventricular complexes (PVCs), 21 males (mean age 56 +/- 8 years) with chronic ischemic heart disease and PVCs underwent symptom-limited treadmill exercise testing and 24-hour ambulatory monitoring before and after 2 weeks of placebo medication. Linear regression analysis was used to describe the relationship between baseline and placebo PVC frequency for various indexes of ventricular ectopic activity and to establish 95% and 99% one-tailed confidence intervals for this relationship within the group of 21 patients. The lower limit of baseline PVC frequency for which the procedure could distinguish a placebo from a true drug response, termed the "sensitivity threshold," was an average frequency of 2.2 PVCs/hour for ambulatory electrocardiographic monitoring and 1.2 PVCs/min for treadmill exercise testing. All patients exceeded the sensitivity threshold on baseline ambulatory ECGs, but only 38% of patients did so on baseline treadmill exercise tests. To establish antiarrhythmic efficacy with 95% confidence, the minimal percent reduction of PVCs between baseline and placebo visits was 68% for treadmill exercise testing and 65% for ambulatory electrocardiography. Although these standards were developed in patients with chronic ischemic heart disease, the model can be used to establish antiarrhythmic drug efficacy in any patient group.     

The food preservative potential of essential oils: is lemongrass the answer?

Several essential oils of medicinal plants possess proven antimicrobial activity and are suitable for applications on the food industry. The oil from Cymbopogon citratus (lemongrass) has been reported to have a wide range of biological activities. However, there are few controlled studies confirming its antimicrobial activity. The aim of our study was to assess the antimicrobial potential of lemongrass oil against a wide spectrum of food spoilage and pathogenic bacteria and yeast in liquid and vapour phase. The chemical composition of the oil was analyzed by gas chromatography; 14 components were identified and geranial (28.93 %), neral (24.30 %) and myrcene (23.92 %) were the most abundant constituents. Lemongrass oil showed potent antimicrobial activity against Gram positive bacteria and exhibited the strongest antifungal effect against Candida albicans and C. parapsilosis. Minimum inhibitory concentration varied from 0.019 to 1.25 mg mL^?1 for Gram positive bacteria and yeasts, indicating Staphylococcus aureus, S. epidermidis and C. albicans as the most susceptible strains. Moreover, the diameter of inhibition zone (DIZ) increased with increasing essential oil (EO) volume. Considerably superior antimicrobial activity was observed in the vapour phase. The DIZ resulting from the exposure to EO vapour was significantly larger than that from the same volume in the liquid phase. The DIZ varied from 22 to 90 mm for Candida strains. There is growing evidence that EO in vapour phase are effective antimicrobial systems and that they do have advantages over the use of oil in liquid phase. Our results imply that lemongrass oil could be useful for the development of novel types of natural preservatives for food control.     

Synthesis of Benzophenones and in vitro Evaluation of Their Anticancer Potential in Breast and Prostate Cancer Cells

Breast and prostate cancers are frequently treated with chemotherapy. Several novel chemicals are being reported for this purpose, particularly synthetic and natural benzophenones. This work reports the synthesis of substituted 2-hydroxybenzophenones through 1,4-conjugate addition/intramolecular cycloaddition/dehydration of nitromethane on key intermediate chromones. Structures were extensively studied by means of 2D NMR spectroscopy and single-crystal XRD. Their cytotoxicity was evaluated in vitro in two breast cancer cell lines (MDA-MB-231 and T47-D) and one prostate cancer cell line (PC3). The most potent compound exhibited good cytotoxic effects against the three cancer cell lines (IC₅₀ values ranging from 12.09 to 26.49 μm ) and induced cell-cycle retardation only on prostate cancer cells, which suggested that it might exert cell-type-specific effects.     

Cellular polypropylene‐based piezoelectric films

Cellular polypropylene‐calcium carbonate based piezoelectric films were obtained using biaxial stretching and gas‐mediated inflation followed by a corona discharge treatment using home‐made devices. The obtained results revealed a cellular structure that develops at the interface between the solid particles and the polymer matrix and the final piezoelectric coefficient was found to depend both on the gas pressure profile and on time. The inflation step gives better results when the gas pressure is increased in stepwise manner allowing the gas to adequately intrude the cavities and maintain the required pressure. The overall results are discussed in terms of processing conditions and in terms of the developed microstructure. POLYM. ENG. SCI., 2012. © 2012 Society of Plastics Engineers     

Continuous size-based focusing and bifurcating microparticle streams using a negative dielectrophoretic system

Dielectrophoresis (DEP) is an electrokinetic phenomenon which is used for manipulating micro- and nanoparticles in micron-sized devices with high sensitivity. In recent years, electrode-based DEP by patterning narrow oblique electrodes in microchannels has been used for particle manipulation. In this theoretic study, a microchannel with triangular electrodes is presented and a detailed comparison with oblique electrodes is made. For each shape, the behavior of particles is compared for three different configurations of applied voltages. Electric field, resultant DEP force, and particle trajectories for configurations are computed by means of Rayan native code. The separation efficiency of the two systems is assessed and compared afterward. The results demonstrate higher lateral DEP force, responsible for particle separation, distributed wider across the channel width for triangular shape electrodes in comparison with the oblique ones. The proposed electrode shape also shows the ability of particle separation by attracting negative DEP particles to or propelling them from the flow centerline, according to the configuration of applied voltages. A major deficiency of the oblique electrodes, which is the streamwise variation of the lateral DEP force direction near the electrodes, is also eliminated in the proposed electrode shape. In addition, with a proper voltages configuration, the triangular electrodes require lower voltages for particle focusing in comparison with the oblique ones.     

Synergistic effect of organoclay fillers based on fluorinated surfmers for preparation of polystyrene nanocomposites

Novel fluorinated reactive surfactants were used for the organic modification of monmorillonite clays. These organoclays were used for the preparation of polystyrene?clay nanocomposites by in‐situ free radical polymerization. Reference systems based on hydrocarbon homologous surfmer and nonpolymerizable surfactants were also used to deduce the effect of the fluorine moiety and the polymerizable function on the morphology and thermal stability of the prepared nanocomposites. Different structural parameters of the surfactants were investigated and modulated for the clay modification including: the nature of surfactant (surfmer/classical surfactant, fluorinated, or hydrocarbonated), the length of the fluorinated chain as well as the length of the hydrocarbon spacers linking the ammonium head to the fluorine chain or the polymerizable acrylic function. Wide angle‐X‐ray scattering (WAXD), thermogravimetric analysis (TGA), and electronic microcopies (TEM and SEM) were used to establish a structure‐morphology, thermal properties relationships, and to highlight the key parameters governing the exfoliation process. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42347.     

Hydrodynamics of pulsed spouted beds: Effects of pulsation waveform,amplitude, and frequency

The effect of flow pulsations is studied via a discrete element model on hydrodynamics of spouted bed, which is being used in many important industries like drying processes. Decreased horizontal air percolation and preserving upward momentum, increased particle circulation, increased particle traverse distance, and better homogeneity are resulted from flow pulsations in spouted beds. Among the waveforms studied, square and triangular waveforms differ most and least from steady spouting, respectively. The predictions indicate that the pulsed spouted bed has the potential to enhance both gas and particle motion, hence being useful in drying and other operations.     

Effects of pH and chloride concentration on pitting corrosion of AA6061 aluminum alloy

Effects of pH solution and chloride (Cl⁻) ion concentration on the corrosion behaviour of alloy AA6061 immersed in aqueous solutions of NaCl have been investigated using measurements of weight loss, potentiodynamic polarisation, linear polarisation, cyclic polarisation experiment combined with open circuit potential transient technique and optical or scanning electron microscopy.The corrosion behaviour of the AA6061 aluminum alloy was found to be dependant on the pH and chloride concentration [NaCl] of solution. In acidic or slightly neutral solutions, general and pitting corrosion occurred simultaneously. In contrast, exposure to alkaline solutions results in general corrosion. Experience revealed that the alloy AA6061 was susceptible to pitting corrosion in all chloride solution of concentration ranging between 0.003 wt% and 5.5 wt% NaCl and an increase in the chloride concentration slightly shifted both the pitting E_pit and corrosion E_cor potentials to more active values. In function of the conditions of treatment, the sheets of the alloy AA6061 undergo two types of localised corrosion process, leading to the formation of hemispherical and crystallographic pits.Polarisation resistance measurements in acidic (pH = 2) and alkaline chloride solutions (pH = 12) which are in good agreement with those of weight loss, show that the corrosion kinetic is minimised in slightly neutral solutions (pH = 6).