Occupational factors and renal disease

The male-to-female ratio of patients requiring dialysis treatment commonly approaches 2:1. It is proposed that environmental factors, particularly occupational exposure to hydrocarbons, may account for the excess number of male patients. The term "hydrocarbon" refers to the aliphatic, alicyclic, aromatic, and halogenated hydrocarbons (carbon tetrachloride, chloroform); glycols (ethylene glycol, diethylene glycol, dioxane, glycerol); and organic solvents. Hydrocarbons commonly find use as solvents in industrial manufacturing practices because of their lipid solubility. Hydrocarbons have long been known to be neurotoxicants, affecting both peripheral and central nervous systems. Although benzene and its derivative have a known association with uroepithelial tumors, there is now a considerable body of evidence suggesting a possible role for hydrocarbon exposure in the development of non-neoplastic renal diseases. This article presents an epidemiological case for such an association and critically reviews the literature.     

Refining the level for anticipated hepatotoxicity in acetaminophen poisoning

Treatment of an acetaminophen overdose with N-acetyl cysteine usually is based on the position of the 4-h acetaminophen (APAP) level on the Rumack-Matthew nomogram; however, there is disagreement on the level at which clinically relevant hepatotoxicity occurs. A retrospective review of all acute adult formulation APAP exposures reported to our poison center between 1986 and 1993 was performed and cases corresponding to the "possible risk or toxicity" range on the nomogram were identified. Our current poison center protocol for APAP poisoning does not recommend treatment with N-acetylcysteine (NAC) in low-risk patients if the 4-h serum APAP level or the extrapolated equivalent falls within the possible toxicity range on the nomogram. Seventeen cases met the inclusion criteria for the study and received no NAC; six additional patients met inclusion criteria but received one or two doses of NAC before therapy was discontinued. No patients in either group demonstrated clinical evidence of hepatotoxicity. This pilot study suggests that patients with no risk factors and APAP levels in the "possible risk" range may not require NAC therapy.     

Learning the higher-order structure of a natural sound

Unsupervised learning algorithms paying attention only to second-order statistics ignore the phase structure (higher-order statistics) of signals, which contains all the informative temporal and spatial coincidences which we think of as 'features'. Here we discuss how an Independent Component Analysis (ICA) algorithm may be used to elucidate the higher-order structure of natural signals, yielding their independent basis functions. This is illustrated with the ICA transform of the sound of a fingernail tapping musically on a tooth. The resulting independent basis functions look like the sounds themselves, having similar temporal envelopes and the same musical pitches. Thus they reflect both the phase and frequency information inherent in the data.     

Reinforcement Learning Rules in a Repeated Game

This paper examines the performance of simple reinforcement learningalgorithms in a stationary environment and in a repeated game where theenvironment evolves endogenously based on the actions of other agents. Sometypes of reinforcement learning rules can be extremely sensitive to smallchanges in the initial conditions, consequently, events early in a simulationcan affect the performance of the rule over a relatively long time horizon.However, when multiple adaptive agents interact, algorithms that performedpoorly in a stationary environment often converge rapidly to a stableaggregate behaviors despite the slow and erratic behavior of individuallearners. Algorithms that are robust in stationary environments can exhibitslow convergence in an evolving environment.     

A new method for evaluating antiarrhythmic drug efficacy

To develop standards for distinguishing antiarrhythmic drug effect from spontaneous variability of premature ventricular complexes (PVCs), 21 males (mean age 56 +/- 8 years) with chronic ischemic heart disease and PVCs underwent symptom-limited treadmill exercise testing and 24-hour ambulatory monitoring before and after 2 weeks of placebo medication. Linear regression analysis was used to describe the relationship between baseline and placebo PVC frequency for various indexes of ventricular ectopic activity and to establish 95% and 99% one-tailed confidence intervals for this relationship within the group of 21 patients. The lower limit of baseline PVC frequency for which the procedure could distinguish a placebo from a true drug response, termed the "sensitivity threshold," was an average frequency of 2.2 PVCs/hour for ambulatory electrocardiographic monitoring and 1.2 PVCs/min for treadmill exercise testing. All patients exceeded the sensitivity threshold on baseline ambulatory ECGs, but only 38% of patients did so on baseline treadmill exercise tests. To establish antiarrhythmic efficacy with 95% confidence, the minimal percent reduction of PVCs between baseline and placebo visits was 68% for treadmill exercise testing and 65% for ambulatory electrocardiography. Although these standards were developed in patients with chronic ischemic heart disease, the model can be used to establish antiarrhythmic drug efficacy in any patient group.     

时间序列数据分析与预处理

时间序列分析中常常遇到的一个问题是如何有效地过滤噪音和约简数据。本文通过修改传统的离散的傅立叶变换来过滤噪音和进行数据的约简，并尽可能保留原始时间序列的全局变化趋势。为检验该方法的有效性，本文同时提出一个新颖的数据分类算法MCC，并用该算法对股票回报率的变化进行预测，实验结果显示，用MCC算法在预处理后的数据上进行预测，其预测的命中率达到63．68％，而在原始数据上进行预测，其预测的命中率只有48．98％。显然，通过对原始数据进行噪音过滤有效地改善了预测的精度。另外，数据的约简也提高了预测算法的效率。     

Junction points in singular optimal control

Optimal control trajectories which contain both non-singular and singular subarcs have been known for almost 40 years. Points where these two types of subarc are joined are known as junction points. Necessary and sufficient conditions for the optimality of these so-called partially singular trajectories are well-known. Necessary conditions for optimality at junction points have also been found. However, for many years the status of McDanell's Conjecture has been unknown. One part of the Conjecture was proved false in 1987 but the remaining part has been hard to prove or disprove. There has been much evidence that the whole of the Conjecture is false in general, although it is true in several special cases. This paper presents a counterexample for the remaining part of McDanell's Conjecture. A minimum of nine equations and two inequalities had to be satisfied at the junction in order for the counterexample to be constructed. The resulting system is of third order and the problem is of Lagrange type.     

Investigation of the Equivalence of National Dew-Point Temperature Realizations in the ?50?°C to +?20?°C Range

In the field of humidity quantities, the first CIPM key comparison, CCT-K6 is at its end. The corresponding European regional key comparison, EUROMET.T-K6, was completed in early 2008, about 4?years after the starting initial measurements in the project. In total, 24 NMIs from different countries took part in the comparison. This number includes 22 EURAMET countries, and Russia and South Africa. The comparison covered the dew-point temperature range from ?50?°C to +20?°C. It was carried out in three parallel loops, each with two chilled mirror hygrometers as transfer standards in each loop. The comparison scheme was designed to ensure high quality results with evenly spread workload for the participants. It is shown that the standard uncertainty due to the long-term instability was smaller than 0.008?°C in all loops. The standard uncertainties due to links between the loops were found to be smaller than 0.025?°C at ?50?°C and 0.010?°C elsewhere. Conclusions on the equivalence of the dew-point temperature standards are drawn on the basis of calculated bilateral degrees of equivalence and deviations from the EURAMET comparison reference values (ERV). Taking into account 16 different primary dew-point realizations and 8 secondary realizations, the results demonstrate the equivalence of a large number of laboratories at an uncertainty level that is better than achieved in other multilateral comparisons so far in the humidity field.