Induction of substances with thymosin-like activity and the potentiation of interferonogenesis in the mechanism of prodigiozan inhibition of 3-methylcholanthrene-induced blastomogenesis

It is shown that prodigiosan is an inductor of synthesis of the substances with the thymosin-like activity. The suggestion about inhibition of 3-methylcholanthrene-induced blastomogenesis by prodigiosan which is mediated by the substances with the thymosin-like activity and interferon is discussed. We present the hypothetical diagram of the development of the above mentioned mechanism. The significance of the obtained findings for elaboration of the immunotherapy is discussed.     

Content of mineral substances in the internal organs of rats on intravenous feeding

The experiments on rats receiving a complete intravenous nutrition (group 1) during 15 days showed that the concentration of natrium, magnesium and iron was increased in the liver and decreased in the spleen as compared to that in controls given normal feeding (group 2). The content of zink and copper (mg%) was significantly lowered in both the organs of rats in group 1. The growth of the liver and spleen mass during parenteral feeding led to a significant rise in the content of natrium, potassium, magnesium, iron, zink and manganese in the whole liver tissue of group 1 rats, while the content of calcium and copper was similar in both groups of animals. The content of natrium, potassium, magnesium, iron and zink in the whole spleen tissue was significantly higher in group 1 rats, while the content of calcium, copper and manganese was similar in both groups of rats. A correlation was revealed between the content of iron and copper in the liver tissue (r = +0.87) and the levels of natrium and magnesium it the spleen tissue (r = +0.78) of group 1 rats. In group 2 rats a correlation was recorded between the content of calcium and manganese in the liver tissue an the levels of natrium and calcium in the spleen (r = +0.85 and +0.86, respectively).     

Pigmented formations in the redfish Sebastes mentella

The study was carried out on 34,960 specimens of redfish out of which 103 individuals were examined histologically. The black spots proved to be superficial (48) and deep melanosis (24). Skin pterinophorosis was revealed in 20 cases. 24 fishes showed benign chromatoblastomas, among them: 14 melanomas, 5 pterinophoromas and 5 pterinomelanophoromas. The tumours occurred only against a background of the spots above 20 cm2 which were observed in 2.4% of fish of the given population. The major part (76.2%) of pigmented lesions did not exceed 5 cm2. 97.6% of spots in females were found between the pectoral and the first dorsal fins, 84% of spots in males--on the head and caudal fin. The pigmented spots in females occurred 2-5 times more often. Genetic factors are, probably, responsible for pigmented neoplasms and lesions in redfish.     

Diet therapy of hyperlipidemia in children

A classification of hyperlipidemias (HLP) in children has been presented in which the main types and forms of the disease are described. The general principles of the diet therapy in children with HLP have been formulated. It is stressed that the ration should include the products containing lipotropic substances, and possessing anticholesterol properties. A special attention is paid to chick-pea (Cicer arietinum) that contains essential amino acids and polyunsaturated fatty acids with antisclerotic and anticholesterol properties. The characteristics of the nutrition regimen for the HLP patients and the food intake frequency have been determined.     

The relation of the biological value of meat proteins to their content of connective tissue

The influence of connective tissue on the biological value of meat products, manufactured from hashed meat, was studied in experiments on growing rats. It was shown that collagen level increase from 6.1 to 14.5% of the total amount of meat proteins improved the growth-mass characteristics of the animals. The actual biological value and the absolute protein utilization had a tendency to lowering, although the difference was not statistically significant. At the same time the effectiveness of tissue protein biosynthesis was not lowered. A conclusion has been made that the results of animal experiments correlate with the clinical data on the positive effect of the increase up to 15% (by protein) of collagen content on the anabolic action of hashed meat protein in humans. A further increase of the connective tissue amount leads to its diminished biological value.