Assessment of the parameters of the growth kinetics of an experimental tumor

A model of the Markov stochastic reproduction and death process is studied as applied to the analysis of time intervals necessary for the experimental tumours to achieve the fixed size. The analysis results have shown nonstationarity of the tumour growth processes during early stages of the tumour development. The presence of such a nonstationarity makes the experimental data interpretation difficult when applying the traditional approach to the tumour cell population kinetics.     

Lipolytic activity of the small intestine in patients with duodenal ulcer

Aspiration biopsy of the mucosa from the beginning of the jejunum was conducted in 43 patients with duodenal ulcer (during exacerbation) and in 15 normal subjects (control group). The biopsy sample was used to study the jejunum activity in providing the initial stages of triglyceride hydrolysis in the area of membrane and intestinal digestion. Monoglyceride lipase activity of biopsy sample homogenate was studied that provided the final stages of triglyceride hydrolysis. As a result of histological investigations of biopsy samples from 34 patients, chronic jejunitis (without atrophy) was diagnosed in 32 of them. Increased lipolytic activity providing the initial stages of triglyceride hydrolysis in the area of intestinal and membrane digestion, and decreased production of monoglyceride lipase by the jejunum have been recorded.     

Relation of actual nutritional characteristics to the health status of retirees and persons of preretirement age employed in mechanical engineering production

Actual nutrition and health state were investigated in 406 males of pre-pension and pension age (40-70 years) engaged in physical work (III category of difficulty) at an engineering plant. The chemical composition of their food was evaluated with respect to 74 chemical elements. The state of the workers' health was evaluated by the data obtained from the registers kept at the Plant medical unit. A relationship has been established between the character of the actual nutrition and the presence of an age-dependent disease, as well as the role of certain nutrients in the development of this or that disease in different age periods. A conclusion has been made on the necessity of the development of differential physiological requirements in the nutrients and energy for elder subjects engaged in the social industry, and inclusion of the rational nutrition into the complex of measures for prevention of age-dependent diseases.     

Tumor and stromal cell counts in the lung clones of transplantable rhabdomyosarcoma of rats determined by flow cytometry

The phase G1-tumour cells of 76 lung clones obtained from rat transplantable rhabdomyosarcoma had near triploid mean DNA content (the diploid index (DI) = 1.46-2.05) and the phase G1/o-stromal cells was characterized by the diploid DNA content. The percent of tumour cells in lung clones determined by flow cytometry varied from 19.7 to 70.9. A correlation is found between the following items: DI; coefficients of variability of DNA content in tumour and stromal cells; the share of the tumour cells in clones and the coefficient of variability of the DNA content in stromal cells; percentage of the tumour cells in the So+ (G2 + M) phase and percentage of the stromal cells etc. Positive correlation is revealed between the coefficient of variability of the DNA content in tumour cells and coefficients of variability of the DNA content in stromal cells (r = 0.83), the negative one (r = 0.38)--between the coefficient of variability of the DNA content of stromal cells of clones and percentage of tumour cells which produce artificial lung metastasis.     

Effect of tetracycline on rat liver mitochondrial oxidative phosphorylation in vivo and in vitro under a varying body allowance of protein

An investigation of the tetracycline action in vivo and in vitro showed it to reduce the rate of oxidative phosphorylation in the rat liver mitochondria which, with an increased concentration or a longer introduction of the drug, gives place to inhibition of respiration. These changes occur following introduction of 100 mg/kg by the 10th day of the experiment and of 20 mg/kg--by the 20th day. The protein-low background is a factor contributing to a speedier effect of tetracycline. Heat-treated tetracycline produces greater changes than does the native drug.