锈蚀钢骨混凝土梁的抗力计算

目的为了保证钢骨混凝土梁在服役过程中的承载能力和构件抗力满足正常使用,并完成预定功能.方法结合锈蚀钢筋混凝土梁抗力分析和钢骨混凝土梁自身的受力性能,介绍了三个阶段的钢骨锈蚀率计算模型,根据钢骨混凝土梁抗弯承载力计算公式,给出了锈蚀钢骨混凝土梁抗力统计参数计算公式,并对抗力统计参数进行了算例分析.结果抗力平均值随时间的增长下降了2.98%,变异系数随时间的增长总体上升了0.69%.结论笔者所建立的抗力统计参数计算公式是合理的,为钢骨混凝土结构耐久性评定等方面研究提供了基本资料.     

RP-HPLC法测定左旋苯甘氨酸乙基邓钾盐的含量

建立了测定左旋苯甘氨酸乙基邓钾盐含量的高效液相色谱方法。采用Thermos C18色谱柱,流动相为0.01 mol/L磷酸盐缓冲液（含0.2%（体积分数）三乙胺,85%（体积分数）磷酸,调节pH值为3.0）-乙腈（体积比为5∶95）为流动相,检测波长为220 nm。样品在pH值为2.0条件下水解后,以水解产物苯甘氨酸为外标,计算左旋苯甘氨酸乙基邓钾盐的含量。左旋苯甘氨酸乙基邓钾盐质量浓度在2～20 mg/mL范围内线性关系良好（r=0.999 9）,回收率为96%～98%。     

Induction of invasive and degradative phenotype in normal synovial fibroblasts exposed to synovial fluid from patients with juvenile rheumatoid arthritis: role of mononuclear cell population

OBJECTIVE: To investigate the effect of synovial fluid (SF) from patients with juvenile rheumatoid arthritis (JRA) on proliferation and induction of degradative and invasive phenotype in normal synovial fibroblasts, and to elucidate the contribution of SF cells to this activity. METHODS: SF and/or conditioned medium (CM) from SF cells were evaluated for their ability to (1) stimulate a proliferative response, (2) induce the "activated phenotype" capable of invading cartilage matrix, and (3) promote the release of key matrix metalloproteinases (MMP) in normal synovial fibroblasts. RESULTS: Proliferation of normal synovial fibroblasts exposed to SF or CM from SF cells of patients with JRA was up to 3 times greater than untreated controls. Concomitant with induction of an activated phenotype in the treated synovial fibroblasts, the activated form exhibited up to 250% invasiveness of cartilage matrix compared to untreated synovial fibroblasts (100%), in addition to releasing increased MMP activity, not normally associated with these quiescent cells. This induction was not solely due to tumor necrosis factor-alpha, transforming growth factor-beta, interleukin 1beta (IL-1beta), and IL-6, as SF and/or CM depleted of these cytokines sustained about 40% of their invasive and inducing ability. We observed that the mononuclear cell (MNC) population that infiltrated into the joint cavity secretes this "inducing activity," which can be maintained in culture up to several weeks. CONCLUSION: Our data suggest that the cellular component of SF releases soluble factor(s) that directly or indirectly contribute to (a) proliferation of synovial fibroblasts, and (b) production and release of extracellular MMP by synovial fibroblasts, thereby inducing a degradative and invasive phenotype culminating in cartilage and bone destruction.     

Primary diffusely infiltrative adenocarcinoma of the colon and rectum

In this study, patient opinion on oral rehabilitation by means of Br?nemark implants was investigated. All patients were referred to a periodontal clinic for implant installation and treated by one and the same operator. Prosthetic restorations were performed by dentists, who had no previous experience with prostheses on implants, but had completed a postgraduate training course. Patient opinion was obtained through questionnaires, pertaining to satisfaction and oral function. A comparison was made between pre-implant situation, short-term (< 4 months) and long-term functioning (3 years) with the implant-restorative rehabilitation. In total, 61 patients participated in the study; 23 received a full lower arch bridge and 18 a full upper arch bridge, while 20 patients got partial bridges. Of 298 installed implants, 7 failed at abutment connection (2.3%) and 1 during the 3-year follow-up interval (0.3%). The study results indicated that a great majority of patients were very satisfied with the treatment. Comfort with eating, aesthetics, phonetics and overall satisfaction improved significantly and nearly all patients said that they would undergo the treatment again or recommend it to others. Patients experienced their implants as "natural" teeth. The conclusion is that rehabilitation ad modum Br?nemark, even in the hands of non-specialized dentists, can be of high quality, improving oral function and satisfying the needs and demands of patients.     

Cell proliferation induced by 8-oxoguanosine and 8-methylguanosine, two adducts produced by free radical attack on ribonucleosides and RNA

The vowel "eh" was used to study auditory-nerve responses at high sound levels (60-110 dB). By changing the playback sampling rate of the stimulus, the second formant (F2) frequency was set at best frequency (BF) for fibers with BFs between 1 and 3 kHz. For vowel stimuli, auditory-nerve fibers tend to phase-lock to the formant component nearest the fiber's BF. The responses of fibers with BFs near F2 are captured by the F2 component, meaning that fibers respond as if the stimulus consisted only of the F2 component. These narrowband responses are seen up to levels of 80-100 dB, above which a response to F1 emerges. The F1 response grows, at the expense of the F2 response, and is dominant at the highest levels. The level at which the F1 response appears is BF dependent and is higher at lower BFs. This effect appears to be suppression of the F2 response by F1. At levels near 100 dB, a component 1/component 2 transition is observed. All components of the vowel undergo the transition simultaneously, as judged by the 180 degrees phase inversion that occurs at the C2 transition. Above the C2 threshold, a broadband response to many components of the vowel is observed. These results demonstrate that the neural representation of speech in normal ears is degraded at high sound levels, such as those used in hearing aids.     

从开放性实验谈我校实验室开放

实验室开放工作是实验教学改革的重要内容,文章结合安徽蚌埠学院的实际情况,着重从实验室开放的必要性、实验室开放的主要内容、实验室开放的组织与实施等方面进行了阐述,这对更好开展实验室开放工作具有实践意义。     

基于区域生长处理的视频运动车辆提取新方法

车辆提取在视频交通流量检测系统中是最重要、最关键的一环。提出一种基于区域生长算法的简单、快速的车辆提取方法。这种方法通过差分图像估计阴影灰度近似值,然后用该值作为参考值删除输入图像属于背景和阴影的像素,最后得到运动车辆图像。利用该方法进行了大量的实验,从实验结果来看,此方法具有较好的稳定性和有效性;从计算时间来看,该方法也能满足实时系统的需要。     

Plasminogen activator inhibitor-1 released from activated platelets plays a key role in thrombolysis resistance. Studies with thrombi generated in the Chandler loop

To investigate the potential role of plasminogen activator inhibitor-1 (PAI-1), which is released from the alpha-granules of activated platelets, in thrombolysis resistance, we employed a model (the "Chandler loop") that mimics the formation of arterial thrombi in vivo and that can be manipulated in terms of rheological parameters and composition of blood cells. Light and electron microscopy revealed that the distribution of blood cells in Chandler thrombi is polarized, as it is in arterial thrombi, resulting in platelet-rich "white heads" and red blood cell-rich "red tails.". Resistance toward tissue-type plasminogen activator (TPA)-mediated thrombolysis parallels the presence of platelets that are fully activated in this system. We demonstrate that the PAI-1 released by the alpha-granules is preferentially retained within the thrombus and that the concentration of PAI-1 antigen is higher in the head than in the tail of the thrombus. The relative thrombolysis resistance of the heads of Chandler thrombi can be largely abolished by inclusion of an anti-PAI-1 monoclonal antibody that blocks that inhibitory activity of PAI-1 toward TPA. We propose that PAI-1, released from activated platelets, plays a key role in thrombolysis resistance and/or reocclusion after thrombolytic therapy. This is due to binding of PAI-1 to polymerized fibrin within the thrombus, followed by inhibition of TPA-mediated fibrinolysis.     

Neuropsychological performance and CD4 levels in HIV-1 asymptomatic infection

The performance of 68 HIV-1 seropositive asymptomatic (HIV+) subjects stratified on CD4 levels were compared with 82 HIV-1 seronegative (HIV-) subjects on a battery of neuropsychological, mood state, and perceived health status measures. The neuropsychological test battery included measures of attention, reaction time, memory, intellectual ability, psychomotor speed, frontal lobe or "executive" function, and decision time. None of the HIV+ subjects were taking antiviral agents. The groups did not differ for age, mood state, or WAIS-R Verbal and Performance IQ scores. Due to group differences for education and weekly ethanol consumption, both variables were used as covariates in multivariate analyses of variance. Relatively few differences were observed between subgroups of HIV+ patients or between these subgroups and control subjects. These data suggest that factors other than absolute levels of immunosuppression as expressed by CD4 levels alone, appear to be responsible for the deficits observed in HIV+ asymptomatic patients.     

珠宝设计中探寻对意境美的表现

意境这个概念作为中国古典美术的最高审美理想,它的形成及发展都带有鲜明的民族特色。研究珠宝设计中对意境美的表现——探寻中国传统的审美理想在当下设计艺术中的运用,对于寻求当代珠宝设计民族化的道路具有重大意义。通过对意境的艺术建构的分析,找到在珠宝设计中表达意境美的方法:首先,创构意象;其次,运用对比与调和的手法建构意象间的内在联系,最终实现在珠宝设计中对意境美的表现。