浅谈设备管理与节能降耗

设备管理是技术管理,也是资源管理,节能降耗任重道远.重视新购设备的设计、选型和制造;应用新技术、新工艺和新材料,做好设备技术改造,及时淘汰落后的高耗能设备;充分发挥员工的聪明才智,积极开展小改小革和修旧利废工作;注重设备备件管理与使用,提高备件利用率:严把设备大修、维修质量关;加强落实设备点检制度,开展设备预防性维护工作.这些都是企业降低成本求得发展的重要组成部分.     

Effects of supplementing glycerol and soybean oil in drinking water on feed and water intake, energy balance, and production performance of periparturient dairy cows

The objective of this study was to determine the effects of supplementing glycerol and soybean oil in drinking water on feed and water intake, calculated energy balance, and production performance of periparturient dairy cows. Ninety multiparous Holstein dairy cows were randomly assigned to 1 of 3 treatments: 1) no nutrients supplemented in the drinking water (control); 2) 20 g/L of glycerin supplemented in the drinking water (glycerol); and 3) 10 g/L of soybean oil supplemented in the drinking water (SBO). The trial lasted from 7 d prepartum to 7 d postpartum. Cows were offered a close-up and milking cow TMR for ad libitum intake, pre- and postpartum, respectively. The dry matter intake of cows supplemented with glycerol and SBO was lower than for the control cows throughout the experimental period but not different from each other. Water intake for the control cows was greater than the average for the glycerol and SBO cows prepartum, and greater than for SBO cows but similar to that of glycerol cows postpartum. Glycerol cows consumed more water than SBO cows. There were no differences in energy intake and energy balance of the cows pre- and postpartum. Serum triacylglycerol concentration for glycerol cows was lower than for the control and SBO cows prepartum and was lower than for the SBO cows postpartum. There were no differences in the serum nonesterified fatty acids and glucose concentrations throughout the experiment. There were no differences in the serum β-hydroxybutyrate (BHBA) concentrations at parturition, but serum BHBA concentration of the glycerol cows was greater than for control and SBO cows during the prepartum period. However, during the postpartum period, serum BHBA concentrations of the control cows were greater than for glycerol and SBO cows. There were no differences in calf birth weights or milk yield and composition. Although the glucogenic property of glycerol supplemented in the drinking water at 20 g/L may not have been sufficient to elicit a milk yield response, it did reduce the concentration of BHBA postpartum.     

A Method to Measure Static Charge on a Filter Used for Gravimetric Analysis

Static charge present on a filter contributes substantial error to low-level mass measurements. The measurement and sources of static charge are not well understood and this article presents a fundamental method of static charge measurement. As predicted by other researchers, triboelectric charging was found to generate significant static charge on a filter when using 2007 Diesel particulate matter (PM) measurement protocols. Measurements made using our method indicate that PM filters are rapidly and effectively neutralized by ²¹⁰ Polonuim ( ²¹⁰ Po) sources. The neutralization of charge occurred exponentially with characteristic time constants (the time it takes for the charge on the filter to decay by 63%) of 0.4 and 0.7 s, depending on the strength of the source. The experimental neutralization time constants were consistent with theory. The charge remaining on highly charged 47 mm Teflon and TX40 filters after 5 s of neutralization with year old ²¹⁰ Po sources biased the true filter mass by <1 μg when the filters were weighed with a 1 μg resolution Cahn microbalance.     

Effect of high hydrostatic pressure and whey proteins on the disruption of casein micelle isolates

High hydrostatic pressure disruption of casein micelle isolates was studied by analytical ultracentrifugation and transmission electron microscopy. Casein micelles were isolated from skim milk and subjected to combinations of thermal treatment (85 degrees C, 20 min) and high hydrostatic pressure (up to 676 MPa) with and without whey protein added. High hydrostatic pressure promoted extensive disruption of the casein micelles in the 250 to 310 MPa pressure range. At pressures greater than 310 MPa no further disruption was observed. The addition of whey protein to casein micelle isolates protected the micelles from high hydrostatic pressure induced disruption only when the mix was thermally processed before pressure treatment. The more whey protein was added (up to 5 g/l) the more the protection against high hydrostatic pressure induced micelle disruption was observed in thermally treated samples subjected to 310 MPa.     

Effects of extensive crossfostering on performance of pigs on a farm

OBJECTIVE: To compare mortality and growth rates of pigs subjected to continuous or limited crossfostering. DESIGN: Prospective study. ANIMALS: 80 liters containing 879 pigs. PROCEDURE: In half of the litters, crossfostering was limited to the first 2 days of life. In the other litters, pigs were crossfostered throughout the lactation period to maintain uniform body weights within litters. RESULTS: Restricting crossfostering to the first 2 days of life resulted in a 20% increase in body weight at weaning, compared with crossfostering throughout the nursing period. Mortality rates did not differ between the limited and continuous crossfostering groups. CLINICAL IMPLICATIONS: The emphasis placed on reducing variation of body weights within litters is unwarranted and veterinarians should advise limiting crossfostering to the first 2 days of life. Excessive crossfostering late in the nursing period may be identified by low within-litter SD of mean body weight.     

Cow milk does not affect adiposity in growing piglets as a model for children

The effect of milk consumption on childhood obesity is unclear and a direct demonstration of an association is needed. In the present study, we used piglets as a model for prepubertal children to determine the effect of milk on adipose tissue. Two studies were conducted: study 1 with 5-wk-old male piglets (n = 8) and study 2 with 8- to 9-wk-old male piglets (n = 12). The piglets were fed a normal growing diet and randomly assigned to receive daily either 750 mL of whole cow milk or an isocaloric maltodextrin solution (control). For approximately 12 wk, body weight, feed intake, and subcutaneous back fat thickness were determined ultrasonographically and recorded. At euthanasia, back and neck fat thicknesses were measured and samples of back fat were collected for adipose histology. In study 1, but not study 2, piglets receiving milk grew more and ate more compared with control. In study 1, both back fat and neck fat thickness were greater in the milk-fed piglets and they had a higher frequency of small adipocytes and a lower frequency of intermediate and large adipocytes compared with controls. In study 2, control pigs had a significantly greater frequency of intermediate adipocytes but the milk-fed piglets tended to have a higher frequency of the largest adipocytes. In conclusion, milk has no apparent causal or consistent effect on adipose tissue in growing piglets.     

Ketamine attenuates and reverses morphine tolerance in rodents

BACKGROUND: The development of tolerance complicates the use of morphine to manage persistent pain. N-methyl-D-aspartate receptor antagonists can attenuate or reverse morphine tolerance. The authors studied ketamine's ability to modulate morphine tolerance. METHOD: Tolerance was produced in mice given morphine subcutaneously and was assessed by a cumulative dose-response analysis using the tail-flick test. The ability of ketamine at 0.3, 3, or 10 mg/kg given subcutaneously before and after morphine to attenuate the development of tolerance was assessed. The ability of 10 mg/kg ketamine to reverse tolerance produced by the subcutaneous implantation of morphine pellets to mice was also assessed. Rats were made tolerant to intraspinal morphine and the effects of the coadministration of 12 micrograms intraspinal ketamine were assessed. RESULTS: Morphine given subcutaneously produced a fivefold increase in the median effective (ED50) dose of morphine, which was dose-dependently attenuated by subcutaneously administered ketamine. A tenfold increase in the morphine ED50 produced by morphine pellets was completely reversed by ketamine given subcutaneously. Intraspinal morphine produced a 46-fold increase in its ED50, which was almost completely attenuated by the coadministration of intraspinal ketamine. CONCLUSIONS: Systemically administered ketamine attenuates and reverses systemically induced morphine tolerance in mice, and intraspinal ketamine attenuates tolerance produced by intraspinal morphine in rats.     

DNA minor groove recognition by a tetrahydropyrimidinium analogue of hoechst 33258: NMR and molecular dynamics studies of the complex with d(GGTAATTACC)2

Hoechst 43254 (H43254), a 2,3,4,5-tetrahydropyrimidin-1-ium analogue of the bis-benzimidazole minor groove binding agent Hoechst 33258 (H33258), has been studied by NMR and restrained molecular dynamics in its complex with d(GGTAATTACC)2. We investigate the origin of the enhanced complex stability afforded by the replacement of the N-methylpiperazine ring of H33258 with the tetrahydropyrimidinium ring of H43254, the latter presenting the opportunity for specific minor groove-directed recognition through a pyrimidinium NH. A set of 25 drug-DNA NOEs define the binding site with some precision and are used as part of the structural analysis using restrained molecular dynamics simulations considering explicit solvation and the treatment of electrostatic interactions using the particle mesh Ewald method within AMBER 4.1. Starting with three different initial structures with the drug located at different sites in the groove (pairwise RMSD 4.3-12.6 A) we arrive at three very similar structures (pairwise RMSD 0.80-1.34 A) representing one converged binding site at the centre of the AATT tract. Two of the three structures show the tetrahydropyrimidinium ring to be suitably positioned for an -NH to adenine N3 hydrogen bond suggesting that electrostatic interactions may play an important role in the enhanced affinity as well as imparting additional A-T specificity. The NMR data show that the pyrimidinium NH interaction is dynamic since signal averaging from the two sides of the ring indicate rapid rotations in the bound form.     

The kinetics of mannose 6-phosphate receptor trafficking in the endocytic pathway in HEp-2 cells: the receptor enters and rapidly leaves multivesicular endosomes without accumulating in a prelysosomal compartment

Previous work on classical olfactory learning and memory in flies has suggested at least four distinct phases of memory consolidation. Similarly, our behavioral and pharmacological analyses also provided clear evidence for at least four pharmacologically distinct memory phases in flies after operant conditioning. Anesthesia-resistant memory (ARM) is present between about 20 and 120 min after training, and susceptible to disruption by the ATPase deactivating chemicals such as ouabain and ethacrynic acid (EA). Long-term memory (LTM) is activated at least 150 min after training, and can be disrupted by protein synthesis inhibitors such as cycloheximide (CXM). In addition, a very short-term memory (pre-STM) is demonstrated by feeding flies with potassium chloride (KCl), which has been shown to disrupt the short-term memory. These observations confirm our previous argument that memory formation in flies involves an intricate, multiple-phase pathway of consolidation.