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81.
Omar AL Zabir 《硅谷》2005,(5):103-110
所有的Microsoft Office应用程序都构建在支持自动化的对象模型之上。任何开发人员都能够使用对象模型来驱动应用程序UI以及添加、编辑和删除内容,就像一个真正的用户在与应用程序交互。丰富对象模型结合自动化支持使Office应用程序真正成为可扩展和可插接的。为了扩展Microsoft Word的行为而满足每个人自身的需要,任何人都能够在很短的时间里编写出一个强大的外接程序。作为优秀的面向对象开发人员,我们使用丰富的结构和优秀合理的对象模型(遵循模型一视图一控制器设计模式(MVC)来开发自己的应用程序。 相似文献
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RIDA AL‐ADAMAT SERWAN M. J. BABAN IAN FOSTER 《The International journal of environmental studies》2013,70(3):337-350
The Jordanian government has encouraged irrigated agriculture since the early 1990s by providing low cost loans to drill private wells. The impacts of this practice on land use change were examined within a small (362 km2) area of the Jordanian Badia using Geoinformatics. Aerial photographs, SPOT and Landsat TM imageries were used, in a GIS environment, to map and examine changes in the farming patterns since 1990. Field surveys and questionnaires were used to ground truth the remotely sensed data. The results indicate that the cultivated area has increased from just 28.5 ha in 1990 to over 1000 ha in 2000 and that the number of farms has increased from 2 to 32 over the same time period. Furthermore, farm locations are moved annually restricted by the position of the well and land availability; this also causes land use change. 相似文献
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Jeremy M. Rathfon Zoha M. AL‐Badri Raja Shunmugam Scott M. Berry Santosh Pabba Robert S. Keynton Robert W. Cohn Gregory N. Tew 《Advanced functional materials》2009,19(5):689-695
The chemical sensing of nerve gas agents has become an increasingly important goal due to the 1995 terrorist attack in a Tokyo subway as well as national security concerns in regard to world affairs. Chemical detection needs to be sensitive and selective while being facile, portable, and timely. In this paper, a sensing approach using a pyrene imine molecule is presented that is fluorimetric in response. The detection of a chloro‐Sarin surrogate is measured at 5 ppmv in less than 1 second and is highly selective towards halogenated organophosphates. The pyrene imine molecule is incorporated into polystyrene films as well as micrometer and sub‐micrometer fibers. Using both a direct drawing approach and electrospinning, micrometer and nanofibers can be easily manufactured. Applications for functional sensing micrometer and nanofibers are envisioned for optical devices and photonics in addition to solution and airflow sensing devices. 相似文献
86.
AL Hughes 《Canadian Metallurgical Quarterly》1999,49(2):106-114
PURPOSE: Because intraperitoneal (i.p.) therapy may provide a therapeutic advantage and because hyperthermia enhances carboplatin (CBDCA) cytotoxicity, we evaluated the feasibility, toxicity, and pharmacokinetics of CBDCA given via continuous hyperthermic peritoneal perfusion (CHPP) in patients with small-volume residual ovarian cancer. Patients and METHODS: Six patients underwent optimal cytoreductive procedures (residual disease < or =5 mm) as initial treatment of stages II and III epithelial ovarian adenocarcinoma. All patients received a 90-min CHPP at a CBDCA dose of 800-1200 mg/m2, with the perfusate being recirculated rapidly from a reservoir through a heat exchanger, resulting in i.p. temperatures of 41-43 degrees C. Plasma, perfusate, and urine samples were collected and platinum was quantified by flameless atomic absorption spectrophotometry. RESULTS: At no time did any patient's core temperature exceed 40 degrees C. Peak perfusate platinum concentrations were 8- to 15-fold higher than peak ultrafilterable plasma concentrations. The permeability-area product was extremely high and variable (14-90 ml/min), resulting in a regional advantage of 1.9-5.3. The percentage of the dose absorbed ranged widely from 27% to 77%. Dose-limiting hematologic toxicity was observed at a dose of 1200 mg/m2 and this was associated with a CBDCA AUC in plasma of 11 mg min ml(-1). CONCLUSION: CHPP with CBDCA was safely given to three patients at a dose of 800 mg/m2, and dose-limiting hematologic toxicities observed at 1200 mg/m2, correlated with the plasma CBDCA exposure established when lower doses of CBDCA are given systemically. The pharmacokinetic data are consistent with the expected effect of vigorous mixing on the exposed peritoneal surface area. Variable drug absorption and clearance make the prediction of systemic exposure highly uncertain. These findings may have important implications for novel therapies given i.p. 相似文献
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Knowledge about the sizes of peptides generated by proteasomes during protein degradation is essential to fully understand their degradative mechanisms and the subsequent steps in protein turnover and generation of major histocompatibility complex class I antigenic peptides. We demonstrate here that 26 S and activated 20 S proteasomes from rabbit muscle degrade denatured, nonubiquitinated proteins in a highly processive fashion but generate different patterns of peptides (despite their containing identical proteolytic sites). With both enzymes, products range in length from 3 to 22 residues, and their abundance decreases with increasing length according to a log-normal distribution. Less than 15% of the products are the length of class I presented peptides (8 or 9 residues), and two-thirds are too short to function in antigen presentation. Surprisingly, these mammalian proteasomes, which contain two "chymotryptic," two "tryptic," and two "post-acidic" active sites, generate peptides with a similar size distribution as do archaeal 20 S proteasomes, which have 14 identical sites. Furthermore, inactivation of the "tryptic" sites altered the peptides produced without significantly affecting their size distribution. Therefore, this distribution is not determined by the number, specificity, or arrangement of the active sites (as proposed by the "molecular ruler" model); instead, we propose that proteolysis continues until products are small enough to diffuse out of the proteasomes. 相似文献
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In the preliminary phase of this study, a selective isolation medium was developed. Using the new medium, 24 strains of Bacillus Spp. that elevate tomato juice pH were isolated from garden soil or natural vegetative materials. Two jars of home-canned, water-bathed tomatoes contained sporeformers which produced noneffervescent spoilage. All strains were morphologically and physiologically different from 2 flat-sour strains of B. coagulans and B. licheniformis strains, but similar to a previous isolate from home-canned, spoiled green beans that elevated pH. The new medium may have future applications in isolation and enumeration of other acidurics including yeast-like microorganisms. 相似文献
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