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71.
72.
KJ Barakat K Cheng WW Chan BS Butler TM Jacks KD Schleim DF Hora GJ Hickey RG Smith AA Patchett RP Nargund 《Canadian Metallurgical Quarterly》1998,8(11):1431-1436
A new class of potent, orally active phenyl piperazine-based GH secretagogues have been discovered from attempts to mimic the arrangement of the phenyl substituent in the spiroindanyl piperidine and spiroindoline sulfonamide privileged structures of 4 and 1, respectively. The best of these compounds, 18 (EC50 = 2.8 nM) is nearly as potent as MK-0677 for releasing GH from rat pituitary cells. 相似文献
73.
AC Buenafe H Offner M Machnicki H Elerding K Adlard R Jacobs AA Vandenbark G Adamus 《Canadian Metallurgical Quarterly》1998,161(4):2052-2059
T cells infiltrating the iris/ciliary body of Lewis rats with anterior uveitis (AU) that had been induced by myelin basic protein (MBP) immunization were previously found to share surface markers common to the T cells that cause experimental autoimmune encephalomyelitis (EAE). To determine whether these AU-associated T cells are in fact the same as those that infiltrate the central nervous system to cause EAE, we examined TCR V gene expression in T cells infiltrating the anterior chamber in rats with AU. As with EAE, we found a biased expression of Vbeta8.2 and Valpha2 in the iris/ciliary body and, although one would expect an influx of nonspecific inflammatory T cells, these biases were still evident at the peak of AU. An analysis of the TCR Vbeta8.2 and Valpha2 sequences derived from the iris/ciliary body demonstrated the presence of the same complementarity determining region 3 motifs found in MBP-specific T cells that are pathogenic for EAE and found in T cells derived from the central nervous system of rats with EAE. Finally, T cells isolated from the iris/ciliary body of rats with AU were found to proliferate in a specific fashion to MBP Ags. Thus, it appears that MBP-specific T cells are pathogenic for AU as well as EAE in the Lewis rat. In addition, the long-term presence of this highly restricted MBP response in the iris/ciliary body indicates that distinct immunoregulatory mechanisms exist in the environment of the eye. This provides an interesting model with which to address questions pertaining to the nature of T cells infiltrating the eye and their regulation during EAE and other systemic diseases. 相似文献
74.
AA Skolnick 《Canadian Metallurgical Quarterly》1998,279(11):816-817
75.
76.
This paper describes a new optoelectronic device—an optical transistor that provides power amplification of output visible
radiation. The optical transistor is structurally based on a metallized semiconductor plate with a microchannel gap in the
form of a planar Mach-Zehnder interferometer. A device of the light-light type is controlled by modulating the refractive
index in one arm of the interferometer.
Pis’ma Zh. Tekh. Fiz. 24, 17–21 (January 26, 1998) 相似文献
77.
AA Gubareva 《Canadian Metallurgical Quarterly》1998,(6):141-143
Systemic enzymes (wobenzime and wobe-mugos) were approved, that had been prescribed as part of polychemotherapy to 24 patients with malignant lymphomas, who presented with large masses of lymphatic nodes poorly resorbable against the background of polychemotherapy and who were assigned for a high-total dose irradiation, which fact would undoubtedly entail sclerosing of adjacent intact tissues. The use of the enzymes made for the optimum realization of the polychemotherapy effect and permitted avoiding a good many of undesirable side events and complication thereof. The above systemic enzymes are well tolerated by patients; they induce no significant changes in the cellular composition or in blood biochemical indices. 相似文献
78.
Automation and Remote Control - The paper considers the problem of constructing a convex subset of the largest area in a nonconvex compact set on the plane as well as the problem of constructing a... 相似文献
79.
Development of monolithic catalysts with low noble metal content for diesel vehicle emission control
Yashnik S. A. Kuznetsov V. V. Ismagilov Z. R. Ushakov V. V. Danchenko N. M. Denisov S. P. 《Topics in Catalysis》2004,30(1-4):293-298
Topics in Catalysis - Monolith washcoated catalysts with potential for diesel emission control have been developed. Two types of catalysts have been prepared for further study: (1) MnO x supported... 相似文献
80.
S.A. Yashnik Z.R. Ismagilov V.V. Kuznetsov V.V. Ushakov V.A. Rogov I.A. Ovsyannikova 《Catalysis Today》2006,117(4):525-535
A synergetic effect in the catalytic activity has been found after palladium introduction in Mn–Al–O systems. The magnitude of the synergetic effect depends on the types of the oxidic manganese species: oxide Mn3O4, spinel (Mn, Mg)[Mn, Al]2O4 or hexaaluminate (Mn, Mg)LaAl11O19. The synergetic effect of Pd and manganese-containing compounds is observed only if palladium is introduced to the low-temperature precursor of the manganese alumina spinel or manganese hexaaluminate. The synergetic effect is not observed when high-temperature samples with formed spinel or hexaaluminate phases are modified with Pd. 相似文献