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Solute carrier family 11 member a1 (Slc11a1), formerly known as Nramp1/Ity/Lsh/Bcg, is a proton/divalent cation antiporter that regulates susceptibility to infectious and autoimmune disease. Here we review recent studies on (1) the role of Slc11a1 in iron metabolism and iron recycling in macrophages; (2) the use of mouse breeding and introgression of knockouts onto Slc11a1 congenic backgrounds for genes encoding the multiple pleiotropic functions associated with Slc11a1; and (3) associations/linkages of SLC11A1 with human disease and how these relate to functional promoter region polymorphisms. 相似文献
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Arvind Singh Hiba Al-Reefy Richard Hewitt Bhik Kotecha 《European archives of oto-rhino-laryngology》2008,265(12):1489-1494
ApneaGraph relies on measuring pressure and airflow simultaneously at different levels in the pharynx identifying the segment
of airway obstruction and providing baseline respiratory parameters. This study aims to evaluate ApneaGraph and correlate
results with both sleep nasendoscopy and polysomnography. This was a prospective study of 49 patients with snoring and/or
obstructive sleep apnoea. Thirty of the these patients underwent a PSG and an ApneaGraph study simultaneously in the Sleep
Lab. Nineteen patients attended the day surgery unit and had a sleep nasendoscopy with a 10-min ApneaGraph analysis. Polysomnography
was used to validate the ApneaGraph system. There are no significant differences (independent t test, P > 0.15) between ApneaGraph compared to Polysomnography based on the apnoea–hypopnoea index, total number of apnoeic events,
average oxygen saturations and maximum desaturation. This suggests that the ApneaGraph can be used to assess OSA. Statistically,
there is poor correlation between the two groups (Spearman’s ρ 0.29). In the cases of discordance, ApneaGraph places greater
emphasis on a lower pharyngeal contribution. This unique study analyses the ApneaGraph system in the diagnosis of obstructive
sleep apnoea and snoring. It demonstrates the benefits of this new system and highlights certain limitations in localizing
the site and level of pharyngeal obstruction in patients with sleep disorders. 相似文献
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The wave of terror that has befallen the Israeli civilian population over the past two years, striking deep into the heart of towns and cities all over the country, presents a unique challenge for the health care system in general and nursing in particular. This article has a two-fold purpose: (a) to describe discussions that took place with four focus groups consisting of emergency room nurses who had recently cared for victims of terror, and (b) to delineate recommendations for policy enhancement based upon these discussions. Qualitative analysis of the data collected from focus group discussions revealed four stages of personal and professional involvement, each one eliciting a specific response from the nurses: call up to report for duty, waiting for casualties to arrive, caring for the victims, and closure of the event. Nurses identified numerous hardships and great anxiety along with a strong sense of professional fulfillment. Recommendations for policy include: incorporating stress management and debriefing skills in post-basic ER training, designing workshops and drills in trauma care for non-ER nurses who float into the ER in the wake of a multi-casualty act of terror, and developing leadership seminars for head nurses in the ER departments. 相似文献
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State involvement in professional nursing development in Israel: promotive or restrictive 总被引:1,自引:0,他引:1
This article describes the role of the Israeli Ministry of Health's Nursing Division in regulating the development of the nursing profession and the nursing care provided. First, factors influencing professional nursing in Israel and the development of the Ministry of Health's Nursing Division are presented. Then, examples of the Nursing Division's influence on nursing practice, the process of statutory authorization used to facilitate this influence, and future Nursing Division initiatives are discussed. The article concludes by noting that, on balance, ministerial (governmental) involvement strengthens the nursing profession and the quality of nursing care provided, yet may also restrict nurses' private concerns. 相似文献
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Hiba El Hage Chehade Umar Wazir Kinan Mokbel Abdul Kasem Kefah Mokbel 《American journal of surgery》2018,215(1):171-178