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Patients with muscular dystrophy may be prone to nutrient deficiency due to mobility limitations or oropharyngeal weakness. Patients with myotonic muscular dystrophy (DM1) may be particularly prone to nutritional deficiencies from associated dysmotility of the entire gastrointestinal tract. We prospectively evaluated nutritional intake, body composition, and muscle strength in adult patients with DM1 (n = 29) and other muscular dystrophies (n = 22) on two occasions separated by approximately 6 months. Handgrip was significantly lower and knee extension higher for DM1 compared to other dystrophies, with no between-group differences in nutritional intakes. Many patients in both groups demonstrated inadequate nutrient intake of protein, energy, vitamins (water and fat soluble), and minerals (calcium and magnesium). Significant correlations were found between measures of strength and certain individual nutrients (e.g., copper and water-soluble vitamins). These data indicate that a substantial number of adults with muscular dystrophy do not meet current dietary intake recommendations. The potential clinical implications of these findings are discussed. 相似文献
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Yaghoubian B Ngo B Mak M Ostrzega E Tesoro J Mitani GH 《Cutis; cutaneous medicine for the practitioner》2005,75(6):329-338
Skin reactions associated with oral coumarin-derived anticoagulants are an uncommon occurrence. Leukocytoclastic vasculitis (LV) is primarily a cutaneous small vessel vasculitis, though systemic involvement may be encountered. We report 4 patients with late-onset LV probably due to warfarin. All 4 patients presented with skin eruptions that developed after receiving warfarin for several years. The results of skin lesion biopsies were available in 3 patients, confirming LV Cutaneous lesions resolved in all patients after warfarin was discontinued. In 2 of the 4 patients, rechallenge with warfarin led to recurrence of the lesions. LV may be a late-onset adverse reaction associated with warfarin therapy. 相似文献
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Bahareh Sadat Yousefsani 《Toxicology mechanisms and methods》2018,28(2):105-114
In this study, we want to understand whether crocin could prevent mitochondrial damage caused by As III. For this purpose, we determined different mitochondrial toxicity endpoints caused by As III. We evaluated mitochondrial ROS formation, lipid peroxidation, mitochondrial membrane potential (MMP) collapse, mitochondrial outer membrane integrity and cytochrome c release. Our results showed that pretreatment with crocin at a concentration of 25?µg/ml significantly (p?0.001) reduced As III-induced mitochondrial ROS formation, lipid peroxidation, MMP collapse and mitochondrial swelling. Crocin also protected the mitochondria by decreasing the mitochondrial outer membrane damage that leads to reduce the amount of cytochrome c release. These results demonstrated that crocin is a promising antidotal candidate by ameliorating As III-induced oxidative stress through mitochondrial targeting. 相似文献
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Abbas Bagheri Hamed Abbasi Abdolreza Sheibanizadeh Bahareh Kheiri Shahin Yazdani 《Strabismus》2017,25(1):17-22
Purpose: To determine the effect of rigid gas permeable contact lenses (RGPCL) on involuntary eye movements and visual function in hyperopic patients with infantile nystagmus syndrome. Methods: This prospective interventional case series was conducted on 16 patients with infantile nystagmus and hyperopia equal or more than +0.5 D and astigmatism more than -1 D over a 2-year period. A complete ophthalmological examination including determination of best corrected visual acuity (BCVA), contrast sensitivity, and videonystagmography was performed for all patients before and after at least 3 months of RGPCL use, and the outcomes were compared. Results: Thirty-two eyes of 16 patients with mean age of 18.6±4.9 years were enrolled. Mean spherical equivalent refractive error was +1.5±2.35 (range +1 to +6.25) diopters (D); corresponding values were +2.45±2.44 D (range +0.5 to +7.5) for spherical error and +1.90±0.83 D (range +1 to +4) for astigmatism. Monocular BCVA improved from 0.56±0.23 to 0.51±0.23 Log MAR (P=0.007), and binocular BCVA improved from 0.54±0.25 to 0.48±0.24 Log MAR (P=0.01) after fitting RGPCL. Following the use of RGPCL, contrast sensitivity was significantly improved at low (P=0.02) and intermediate (P< 0.001) frequencies but not at high frequencies (P=0.6). The frequency, amplitude, and intensity of nystagmus were decreased significantly after RGPCL use (P<0.001). Conclusion: RGPCL improved monocular and binocular BCVA and contrast sensitivity in hyperopic patients with infantile nystagmus syndrome. Motor indices of nystagmus (frequency, amplitude, and intensity) were also significantly improved after RGPCL use. 相似文献
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Recently, Cu nanoparticles (NPs) encapsulated into various materials as supports (e.g., zeolite, silica) have attracted much devotion due to their unique catalytic properties such as high catalytic activity, intensive reactivity and selectivity through highly protective properties. Nowadays, the superior catalytic activity of Cu-NPs, encapsulated onto zeolite, silica and different porous systems, is extensively investigated and now well-established. As a matter of fact, Cu-NPs are protected from deactivation by this kind of encapsulation. Thus, their exclusion proceeds smoothly, and their recyclability is significantly increased. Cu-NPs have been used as potential heterogeneous catalysts in different chemical transformations. In this review, we try to show the preparation and applications of Cu(0) encapsulated nanocatalysts in zeolite and silica as superior catalytic systems in Cu-catalyzed organic transformations. In addition, the catalytic activity of these encapsulated Cu-NPs in different important organic transformations (such as hydrogenation, oxidation and carbon–carbon bond formations) are compared with those of a variety of organic, inorganic and hybrid porous bearing a traded metal ion. Moreover, the results from the TGA/DTA analysis and optical properties of Cu-complexes are demonstrated. The inherited characteristic merits of the encapsulated Cu-NPs onto zeolite and silica, such as their low leaching, catalytic activity, reusability economic feasibility and originality are critically considered.In this review, the catalytic activity of encapsulated Cu-NPs in different important organic transformations is compared with those of a variety of organic, inorganic and hybrid porous materials bearing a traded metal ion. 相似文献
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A facile, innovative synthesis for the fabrication of NiCo2Se4-rGO on a Ni foam nanocomposite via a simple hydrothermal reaction is proposed. The as-prepared NiCo2Se4-rGO@Ni foam electrode was tested through pxrd, TEM, SEM, and EDS to characterize the morphology and the purity of the material. The bimetallic electrode exhibited outstanding electrochemical performance with a high specific capacitance of 2038.55 F g−1 at 1 A g−1. NiCo2Se4-rGO@Ni foam exhibits an extensive cycling stability after 1000 cycles by retaining 90% of its initial capacity. A superior energy density of 67.01 W h kg−1 along with a high power density of 903.61 W kg−1 further proved the high performance of this electrode towards hybrid supercapacitors. The excellent electrochemical performance of NiCo2Se4-rGO@Ni foam can be explained through the high electrocatalytic activity of NiCo2Se4 in combination with reduced graphene oxide which increases conductivity and surface area of the electrode. This study proved that NiCo2Se4-rGO@Ni foam can be utilized as a high energy density-high power density electrode in energy storage applications.A hybrid supercapacitor comprising a NiCo2Se4-rGO composite has been fabricated on Ni foam and shows high energy and power density and superior flexibility. 相似文献