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101.
Anti‐inflammatory and analgesic activities of cupressuflavone from Cupressus macrocarpa: Impact on pro‐inflammatory mediators 下载免费PDF全文
Eman Al‐Sayed Haidy A. Gad Mohamed El‐Shazly Mohamed M. Abdel‐Daim Abdel Nasser Singab 《Drug development research》2018,79(1):22-28
Hit, Lead & Candidate Discovery |
102.
Introduction and objective
Gestational weight gain (GWG) has been reported to be associated with pregnancy outcomes. The aim of this study was to evaluate the effects of GWG on maternal and birth complications.Materials and methods
A prospective and longitudinal cohort study was conducted among pregnant women who had attended antenatal centers in Constantine, Algeria, between 2013 and 2015. Two hundred pregnant women aged 19 to 41 years old were followed for 9 months of pregnancy. They underwent body weight measurement during routine examination at first, second and third trimester. GWG was categorized as below, within or above the Institute of Medicine (IOM) (2009) recommendations. Data included age and parity. Pregnancy outcomes were analyzed in relation to GWG.Results
Mean GWG was 8.9 ± 5.4 kg. Among all subjects, only 27.5% of women had gained the recommended amount of weight, with 48.5% gaining less than recommended, and 24.0% gaining more than recommended by the IOM. High birth weight was significantly more frequent in women with excessive weight gain, compared to those with normal gain (27.1% vs 14.5%, P = 0.04). The percentage of low birth infants was statistically very high in pregnant women with excessive weight gain, compared to women with normal gain (14.6% vs 3.6%, P = 0.04). The risk of gestational hypertension increased with excessive GWG (P < 0.01).Conclusion
The pregnancy and birth outcomes depend on the women's gestational weight gain. 相似文献103.
Khawla Abu Hammour Mariam Abdel Jalil Walid Abu Hammour 《Saudi Pharmaceutical Journal》2018,26(6):780-785
Objectives
The present study aimed to evaluate the parents' knowledge, attitudes and practices (KAP) towards the use of antibiotics for childhood upper respiratory tract infections (URTIs), at the Jordanian University Hospital.Methods
This was a cross-sectional study. During the study period, 1301 parents of young children completed a validated – structured questionnaire.Results
Gaps in common knowledge related to antibiotics and their use were noted among participants. Nearly half of respondents believed that antibiotics are void from adverse effects, while 72.4% of them believed that a child should be given an antibiotic if it develops fever, even though 60% they were aware that most URTIs were viral in nature. Parents reported that they administered antibiotics to children without medical advice most of the time for various causes, including using a previously prescribed antibiotic for a similar illness (27.1%), or based on pharmacist's recommendation (23.8%).Conclusion
The results demonstrated the need for educational interventions to increase the awareness of parents about antibiotics to reduce inappropriate use and its consequences. 相似文献104.
105.
Afton K. Limberg Meagan E. Tibbo Christopher G. Salib Alex R. McLaury Travis W. Turner Charlotte E. Berry Anthony G. Jay Jodi M. Carter Brad Bolon Daniel J. Berry Mark E. Morrey Joaquin Sanchez-Sotelo Andre J. van Wijnen Matthew P. Abdel 《Journal of orthopaedic research》2020,38(11):2474-2483
The dense formation of abnormal scar tissue after total knee arthroplasty results in arthrofibrosis, an unfortunate sequela of inflammation. The purpose of this study was to use a validated rabbit model to assess the effects on surgically-induced knee joint contractures of two combined pharmacological interventions: celecoxib (CXB) loaded on an implanted collagen membrane, and subcutaneously (SQ) injected ketotifen. Thirty rabbits were randomly divided into five groups. The first group received no intervention after the index surgery. The remaining four groups underwent intra-articular implantation of collagen membranes loaded with or without CXB at the time of the index surgery; two of which were also treated with SQ ketotifen. Biomechanical joint contracture data were collected at 8, 10, 16, and 24 weeks. At the time of necropsy (24 weeks), posterior capsule tissue was collected for messenger RNA and histopathologic analyses. At 24 weeks, there was a statistically significant increase in passive extension among rabbits in all groups treated with CXB and/or ketotifen compared to those in the contracture control group. There was a statistically significant decrease in COL3A1, COL6A1, and ACTA2 gene expression in the treatment groups compared to the contracture control group (P < .001). Histopathologic data also demonstrated a trend towards decreased fibrous tissue density in the CXB membrane group compared to the vehicle membrane group. The present data suggest that intra-articular placement of a treated collagen membrane blunts the severity of contracture development in a rabbit model of arthrofibrosis, and that ketotifen and CXB may independently contribute to the prevention of arthrofibrosis. Statement of clinical significance: Current literature has demonstrated that arthrofibrosis may affect up to 5% of primary total knee arthroplasty patients. For that reason, novel pharmacologic prophylaxis and treatment modalities are critical to mitigating reoperations and revisions while improving the quality of life for patients with this debilitating condition. 相似文献
106.
Ahmed Mohamed Abdel Shafi MBBS BSc Savini Hewage BSc Amer Harky MBChB MRCS MSc 《Journal of cardiac surgery》2020,35(6):1295-1297
The global pandemic caused by COVID-19 has had a significant global impact on healthcare systems. One implication of this pandemic is the cancellation of elective cardiac surgeries and the centralization of services. As a result, hospitals in Europe, North America, and the United Kingdom have had to alter the services offered to patients to be able to cope with service provision for COVID infected patients. Data should be collected during this period to provide a good insight following the lockdown period to understand the implication of such service alteration. Future research should also focus on the effects on long-term mortality and morbidity as well as financial implications on hospitals as a result of these changes. 相似文献
107.
Ahmed Mohamed Abdel Shafi MBBS BSc Mohammed A. Akhtar MBBS BSc MRCP Alexander Smith MBBS BSc MRCS Martin Yates MD MRCS Aung Y. Oo MD FRCSEd 《Journal of cardiac surgery》2020,35(11):3227-3230
Benign cardiac tumors are rare; they can present with nonspecific symptoms and represent a diagnostic challenge to the clinician. We describe an interesting case of a 26-year-old female who presented with a 6-month history of cough, breathlessness, palpitations, dizziness, and fever. Despite repeated clinical reviews in the community, diagnosis of cardiac tumor was not made until she developed decompensated cardiac failure with bilateral pleural effusions and pulmonary edema. Echocardiogram revealed an enormous left atrial mass that extended one-third into left ventricle during systole. The patient underwent successful surgical resection with histological confirmation of a benign atrial myxoma. 相似文献
108.
Lateral unicondylar knee arthroplasty (UKA): Contemporary indications,surgical technique,and results
Matthieu Ollivier Matthew P. Abdel Sébastien Parratte Jean-Noël Argenson 《International orthopaedics》2014,38(2):449-455
Unicompartmental femoro-tibial osteoarthritis usually affects the medial compartment of the knee, but in 10 %, the lateral compartment is primarily involved. Femoral osteotomy is attractive to avoid TKA in younger patients with low-grade unicompartmental osteoarthritis and a valgus deformity. However, only limited functional results can be expected for patients with Ahlback grade 2 or greater osteoarthritis. Moreover, because of previous skin incisions and hardware removal, TKA after femoral osteotomy remains a complex procedure with poor functional results. Unicompartmental knee arthroplasty for both the medial and the lateral compartments has been performed since the 1970s. In a patient with involvement of only one compartment, a medial or a lateral UKA can provide a quicker recovery and enhanced function when compared to TKA. In addition, it preserves bone stock and can be “easily” revised by a TKA. Technical improvements, combined with strict patient selection, have resulted in ten year survivorships greater than 90 %. However, lateral UKA is technically more challenging than medial UKA due to the lower number of indications, as well as the functional anatomy of the lateral compartment. The goals of this article are to present up-to-date information concerning indications, patients’ selection, surgical technique and results of lateral compartment UKA. 相似文献
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