Biodegradable Nanoscale Coordination Polymers for Targeted Tumor Combination Therapy with Oxidative Stress Amplification

Nowadays various inorganic nanoparticles that generate highly reactive hydroxyl radical ( · OH) on the basis of Fenton‐like catalytic activity of metal ions have been designed for chemodynamic therapy. However, the high level of adaptive antioxidants [glutathione (GSH)] in cancer cells could effectively consume · OH to compromise the treatment efficiency and biosafety of these inorganic nanoparticles, and this is a general concern in chemodynamic therapy. Herein, a new biodegradable nanoscale coordination polymer (NCP) is developed by integration of cisplatin prodrug (DSCP) and iron (III) ions through a reverse microemulsion method. The DSCP in the NCPs could react with GSH to release free cisplatin, while the iron (III) ions could be reduced by GSH into iron (II) to enable Fenton reaction, subsequently leading to amplified intracellular oxidative stress. After surface modification of polyethylene glycol (PEG) and cyclo[Arg‐Gly‐Asp‐D‐Phe‐Lys(mpa)] peptide (cRGD), Fe‐DSCP‐PEG‐cRGD shows an excellent targeting effect against α_vβ₃‐integrin overexpressed tumor cells. Furthermore, Fe‐DSCP‐PEG‐cRGD enables significant chemo and chemodynamic therapy with dramatically enhanced therapeutic efficiency in comparison to relative monotherapies. Importantly, Fe‐DSCP‐PEG‐cRGD could be efficiently cleared out from mice through feces and urine postinjection 7 days. The NCP presented in this work is simple and economical, which shows great biodegradability and biosafety for potential clinical translation.     

Embedding ZnSe nanodots in nitrogen-doped hollow carbon architectures for superior lithium storage

Nano Research - Transition metal chalcogenides represent a class of the most promising alternative electrode materials for high-performance lithium-ion batteries (LIBs) owing to their high...     

一种改进型两相静止坐标系增强型锁相环

电网电压中的谐波、不平衡以及直流偏移会在传统两相静止坐标系增强型锁相环(αβ-EPLL)所检测的电网基波电压幅值、频率和相角中产生周期波动,尤其是直流偏移会产生基波频率的周期波动,难以使用低通滤波器直接滤除。提出一种改进的αβ-EPLL结构,在两相信号输入侧引入直流偏移积分器以消除输入直流偏移,在幅值检测环和频率检测环中分别引入延时信号滤波器以消除输入谐波和不平衡的影响。详细的理论分析和实验结果验证了所提出的改进αβ-EPLL的正确性和可行性。     

恒功率低速大扭矩电动机

介绍一种国家专利产品─-新型"恒功率低速大扭矩电动机"的传动原理、结构及其性能特点。     

Cisplatin‐Prodrug‐Constructed Liposomes as a Versatile Theranostic Nanoplatform for Bimodal Imaging Guided Combination Cancer Therapy

Up to date, a large variety of liposomal nanodrugs have been explored for cancer nanomedicine, showing encouraging results in both preclinical animal experiments and clinical treatment of cancer patients. Herein, a phospholipid conjugated with a cisplatin prodrug is used as the major structure component of liposomes together with other commercial lipids via self‐assembling. By doping with 1,1′‐dioctadecyl‐3,3,3′,3′‐tetramethylindotricarbocyanine iodide (DiR), a lipophilic dye with strong near infrared (NIR) absorbance and fluorescence, the obtained DiR‐Pt(IV)‐liposome is found to be an effective probe for in vivo NIR fluorescence and photoacoustic bimodal imaging. Attributing to its intrinsically doped cis‐Pt(IV) prodrug, efficient photothermal conversion ability, and excellent tumor homing ability, DiR‐Pt(IV)‐liposome confers greatly enhanced therapeutic outcomes in the combined photothermal‐chemotherapy. Moreover, Pt(IV)‐liposome is also demonstrated to be an efficient carrier for both small hydrophilic molecules and proteins, which are encapsulated inside the water‐cavity of liposomes, further demonstrating the versatile functions of this nanoplatform. This study develops a unique type of liposomal nanomedicine with a prodrug conjugated phospholipid as the major structure component. Such Pt(IV)‐liposome is featured with advantages including precisely defined/easily tunable drug compositions, stealth‐like pharmacokinetics, efficient tumor passive uptake, and the capabilities to simultaneously load with various types of imaging or therapeutic agents.     

连杆机构的弹性动力平衡

本文介绍了弹性连杆机构震动边的计算方法,指出用传统方法进行弹性机构的平衡可能有害,并以震动力最小为目标进行了弹性连杆机构加重平衡优化,推出了修正构件载面参数实现震动力最小化的新方法。     

OPTICAL OPTIMIZATION FOR LIQUID CRYSTAL TEST BY LASER-CCD SYSTEM

0 INTRODUCTIONBased on the technical development of the dynamic opticalguided mode, high-quality focal light beam and charge-coupleddevice (CCD) are usually used to detect liquid crystal (LC) mole-cule anchor in a small range, and the dynamic response can…     

大速比、高精度、大扭矩新型变速器——谐波齿轮传动

介绍一种新型的传动机构——谐波齿轮传动的原理、特点及其应用.     

颈动脉支架成形术后颅内出血临床分析

【摘要】 目的 探讨颈动脉支架成形术（CAS）后颅内出血的临床特点、发生机制及治疗。方法 回顾性分析2008年1月至2017年1月收治的颈动脉狭窄行CAS术患者,记录并分析术后出血患者临床及影像学资料。结果 513例患者中5例（0.97%）发生颅内出血,均经术后头颅CT/DSA证实。其中男3例,女2例,平均年龄（71.4±5.0）岁;颈动脉狭窄率为90%～99%,出血时间为术中即刻至术后10 d;1例DSA显示同侧基底节区烟雾血管,1例DSA发现穿支动脉出血。3例接受药物保守治疗,其中1例恢复良好,2例死亡;2例接受血肿穿刺引流,遗留偏瘫。结论 CAS术后颅内出血发生率较低,但致死、致残率较高。发病原因较多,术前充分评估、危险因素筛选可降低发生率。出血后积极控制血压,予以镇静、停用抗凝药、减少/停用抗血小板药以及手术干预,可提高患者生存率。
     

移动机器人中视觉里程计技术综述

视觉里程计（VO）是实现移动机器人自主导航的主要技术之一,不同类型的VO技术在不同应用场景中受环境和硬件计算能力的影响,导致其性能各有优劣。概述VO技术的发展历程,对基于传统几何和基于深度学习的两类VO技术的性能进行对比与分析,重点介绍传统VO技术中特征点法的原理及其改进方法。在此基础上,归纳VO领域常用的公共数据集并对部分现有方法进行对比评测,为VO技术的实际应用提供参考和借鉴,并展望该领域未来的发展方向。